Incidence of post tuberculosis chronic obstructive pulmonary disease in a tertiary centre in Malaysia
Pulmonary tuberculosis (PTB) and chronic obstructive pulmonary disease (COPD) are important causes of mortality and morbidity in Malaysia. The number of tuberculosis (TB) cases in Malaysia appears to be increasing and there were 500,000 Malaysians diagnosed with COPD in 2016. A substantial num...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Pusat Perubatan Universiti Kebangsaan Malaysia
2020
|
| Online Access: | http://journalarticle.ukm.my/16272/ http://journalarticle.ukm.my/16272/1/10_ms0414_pdf_20256.pdf |
| _version_ | 1848814010404700160 |
|---|---|
| author | Ban, Andrea Yu-Lin Mohamed Faisal Abdul Hamid, Chong, GY Syed Zulkifli Syed Zakaria, |
| author_facet | Ban, Andrea Yu-Lin Mohamed Faisal Abdul Hamid, Chong, GY Syed Zulkifli Syed Zakaria, |
| author_sort | Ban, Andrea Yu-Lin |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Pulmonary tuberculosis (PTB) and chronic obstructive pulmonary disease (COPD)
are important causes of mortality and morbidity in Malaysia. The number
of tuberculosis (TB) cases in Malaysia appears to be increasing and there were
500,000 Malaysians diagnosed with COPD in 2016. A substantial number of PTB
patients go on to develop post tubular airway disease. Past infection with TB has
been shown to contribute to the aetiology of COPD. We conducted a one year
cross-sectional study in outpatient setting involving adult subjects in Universiti
Kebangsaan Malaysia Medical Centre (UKMMC) with a history of pulmonary
tuberculosis three years prior to the study. We excluded subjects with bronchial
asthma, COPD, interstitial lung disease and bronchiectasis. Airflow obstruction was
defined as FEV1
: FVC ratio <0.70. The COPD Assessment Test (CAT) questionnaire
was used. Eighty-two subjects were recruited with a median age of 52.5 years (IQR
36-62). Male predominance (56.1%) with 29 (35.4%) smokers. Eighteen (22%)
subjects had airflow obstruction. Six (33%) out of these subjects were smokers.
Fourteen(17%) had restrictive pattern and 50 (61%) had normal spirometry results.
Five subjects (22.22%) had mild obstruction, 7 (44.44%) moderate obstruction,
and 6 (33.33%) had severe obstruction. There was a positive correlation between
chest X-ray abnormalities and age with airflow obstruction (P<0.05). Abnormal
spirometry pattern was found in 39% of subjects. Post TB-COPD incidence was
22% in those who completed TB treatment. There appeared to be an association
between abnormal chest radiograph findings with airflow obstruction in subjects
with history of PTB. |
| first_indexed | 2025-11-15T00:27:17Z |
| format | Article |
| id | oai:generic.eprints.org:16272 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:27:17Z |
| publishDate | 2020 |
| publisher | Pusat Perubatan Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:162722021-03-16T01:46:34Z http://journalarticle.ukm.my/16272/ Incidence of post tuberculosis chronic obstructive pulmonary disease in a tertiary centre in Malaysia Ban, Andrea Yu-Lin Mohamed Faisal Abdul Hamid, Chong, GY Syed Zulkifli Syed Zakaria, Pulmonary tuberculosis (PTB) and chronic obstructive pulmonary disease (COPD) are important causes of mortality and morbidity in Malaysia. The number of tuberculosis (TB) cases in Malaysia appears to be increasing and there were 500,000 Malaysians diagnosed with COPD in 2016. A substantial number of PTB patients go on to develop post tubular airway disease. Past infection with TB has been shown to contribute to the aetiology of COPD. We conducted a one year cross-sectional study in outpatient setting involving adult subjects in Universiti Kebangsaan Malaysia Medical Centre (UKMMC) with a history of pulmonary tuberculosis three years prior to the study. We excluded subjects with bronchial asthma, COPD, interstitial lung disease and bronchiectasis. Airflow obstruction was defined as FEV1 : FVC ratio <0.70. The COPD Assessment Test (CAT) questionnaire was used. Eighty-two subjects were recruited with a median age of 52.5 years (IQR 36-62). Male predominance (56.1%) with 29 (35.4%) smokers. Eighteen (22%) subjects had airflow obstruction. Six (33%) out of these subjects were smokers. Fourteen(17%) had restrictive pattern and 50 (61%) had normal spirometry results. Five subjects (22.22%) had mild obstruction, 7 (44.44%) moderate obstruction, and 6 (33.33%) had severe obstruction. There was a positive correlation between chest X-ray abnormalities and age with airflow obstruction (P<0.05). Abnormal spirometry pattern was found in 39% of subjects. Post TB-COPD incidence was 22% in those who completed TB treatment. There appeared to be an association between abnormal chest radiograph findings with airflow obstruction in subjects with history of PTB. Pusat Perubatan Universiti Kebangsaan Malaysia 2020-12 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/16272/1/10_ms0414_pdf_20256.pdf Ban, Andrea Yu-Lin and Mohamed Faisal Abdul Hamid, and Chong, GY and Syed Zulkifli Syed Zakaria, (2020) Incidence of post tuberculosis chronic obstructive pulmonary disease in a tertiary centre in Malaysia. Medicine & Health, 15 (2). pp. 85-95. ISSN 2289-5728 https://www.medicineandhealthukm.com/toc/15/2 |
| spellingShingle | Ban, Andrea Yu-Lin Mohamed Faisal Abdul Hamid, Chong, GY Syed Zulkifli Syed Zakaria, Incidence of post tuberculosis chronic obstructive pulmonary disease in a tertiary centre in Malaysia |
| title | Incidence of post tuberculosis chronic obstructive pulmonary disease in a tertiary centre in Malaysia |
| title_full | Incidence of post tuberculosis chronic obstructive pulmonary disease in a tertiary centre in Malaysia |
| title_fullStr | Incidence of post tuberculosis chronic obstructive pulmonary disease in a tertiary centre in Malaysia |
| title_full_unstemmed | Incidence of post tuberculosis chronic obstructive pulmonary disease in a tertiary centre in Malaysia |
| title_short | Incidence of post tuberculosis chronic obstructive pulmonary disease in a tertiary centre in Malaysia |
| title_sort | incidence of post tuberculosis chronic obstructive pulmonary disease in a tertiary centre in malaysia |
| url | http://journalarticle.ukm.my/16272/ http://journalarticle.ukm.my/16272/ http://journalarticle.ukm.my/16272/1/10_ms0414_pdf_20256.pdf |