Curcumin minimises histopathological and immunological progression in the ankle joints of collagen-induced arthritis rats
Curcumin is a traditionally used spice with a potential to treat various inflammatory diseases including arthritis. This study was aimed at observing curcumin’s effects on the histopathological progression and interleukin-1β (IL-1β) levels in collagen�induced arthritis (CIA). Thirty male Sprague...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pusat Perubatan Universiti Kebangsaan Malaysia
2020
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| Online Access: | http://journalarticle.ukm.my/16267/ http://journalarticle.ukm.my/16267/1/5_ms0390_pdf_82104.pdf |
| _version_ | 1848814008857001984 |
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| author | Kevin TTM, Nur Idanis AS, Anastasha B, Mohd Faris MR, Faizah Othman, Taty Anna Kamarudin, |
| author_facet | Kevin TTM, Nur Idanis AS, Anastasha B, Mohd Faris MR, Faizah Othman, Taty Anna Kamarudin, |
| author_sort | Kevin TTM, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Curcumin is a traditionally used spice with a potential to treat various inflammatory
diseases including arthritis. This study was aimed at observing curcumin’s effects
on the histopathological progression and interleukin-1β (IL-1β) levels in collagen�induced arthritis (CIA). Thirty male Sprague-Dawley rats (150+50 g) were divided
into five random groups. A group was assigned as the normal control (CTRL),
while the remaining were subcutaneously immunised with 150 µg of collagen
emulsion on day 0. CTRL and CIA-Curcumin-d0 groups were supplemented daily
with olive oil (1 ml/kg) and curcumin (110 mg/ml/kg) from day 0, respectively. The
CIA-OV (negative control), CIA-Beta and CIA-Curcumin-d14 groups were given
daily supplementation of olive oil (1 ml/kg), Betamethasone (0.5 mg/ml/kg), and
curcumin (110 mg/ml/kg) from day 14, respectively. The daily oral supplementations
continued until day 42. The study showed that CIA-Beta (**P<0.05) and CIA�Curcumin-d0 (**P=0.01) groups had significantly lower mean histological scores
compared to CIA-OV, respectively. Serum IL-1β levels for CIA-Beta and CIA�Curcumin-d0 were not significantly raised on day 42 as to compared to day 0, and
the mean increment of IL-1β levels from day 0 to day 42 were significantly lower
(**P≤0.01) for all the CIA groups compared to CIA-OV. There was no significant
difference in both mean histological scores and IL-1β levels of CIA-Curcumin-d0
compared to CIA-Beta. Early supplementation of curcumin could potentially
minimise disease progression of CIA in rats. |
| first_indexed | 2025-11-15T00:27:16Z |
| format | Article |
| id | oai:generic.eprints.org:16267 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:27:16Z |
| publishDate | 2020 |
| publisher | Pusat Perubatan Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:162672021-03-16T02:16:33Z http://journalarticle.ukm.my/16267/ Curcumin minimises histopathological and immunological progression in the ankle joints of collagen-induced arthritis rats Kevin TTM, Nur Idanis AS, Anastasha B, Mohd Faris MR, Faizah Othman, Taty Anna Kamarudin, Curcumin is a traditionally used spice with a potential to treat various inflammatory diseases including arthritis. This study was aimed at observing curcumin’s effects on the histopathological progression and interleukin-1β (IL-1β) levels in collagen�induced arthritis (CIA). Thirty male Sprague-Dawley rats (150+50 g) were divided into five random groups. A group was assigned as the normal control (CTRL), while the remaining were subcutaneously immunised with 150 µg of collagen emulsion on day 0. CTRL and CIA-Curcumin-d0 groups were supplemented daily with olive oil (1 ml/kg) and curcumin (110 mg/ml/kg) from day 0, respectively. The CIA-OV (negative control), CIA-Beta and CIA-Curcumin-d14 groups were given daily supplementation of olive oil (1 ml/kg), Betamethasone (0.5 mg/ml/kg), and curcumin (110 mg/ml/kg) from day 14, respectively. The daily oral supplementations continued until day 42. The study showed that CIA-Beta (**P<0.05) and CIA�Curcumin-d0 (**P=0.01) groups had significantly lower mean histological scores compared to CIA-OV, respectively. Serum IL-1β levels for CIA-Beta and CIA�Curcumin-d0 were not significantly raised on day 42 as to compared to day 0, and the mean increment of IL-1β levels from day 0 to day 42 were significantly lower (**P≤0.01) for all the CIA groups compared to CIA-OV. There was no significant difference in both mean histological scores and IL-1β levels of CIA-Curcumin-d0 compared to CIA-Beta. Early supplementation of curcumin could potentially minimise disease progression of CIA in rats. Pusat Perubatan Universiti Kebangsaan Malaysia 2020-12 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/16267/1/5_ms0390_pdf_82104.pdf Kevin TTM, and Nur Idanis AS, and Anastasha B, and Mohd Faris MR, and Faizah Othman, and Taty Anna Kamarudin, (2020) Curcumin minimises histopathological and immunological progression in the ankle joints of collagen-induced arthritis rats. Medicine & Health, 15 (2). pp. 26-36. ISSN 2289-5728 https://www.medicineandhealthukm.com/toc/15/2 |
| spellingShingle | Kevin TTM, Nur Idanis AS, Anastasha B, Mohd Faris MR, Faizah Othman, Taty Anna Kamarudin, Curcumin minimises histopathological and immunological progression in the ankle joints of collagen-induced arthritis rats |
| title | Curcumin minimises histopathological and immunological progression in the ankle joints of collagen-induced arthritis rats |
| title_full | Curcumin minimises histopathological and immunological progression in the ankle joints of collagen-induced arthritis rats |
| title_fullStr | Curcumin minimises histopathological and immunological progression in the ankle joints of collagen-induced arthritis rats |
| title_full_unstemmed | Curcumin minimises histopathological and immunological progression in the ankle joints of collagen-induced arthritis rats |
| title_short | Curcumin minimises histopathological and immunological progression in the ankle joints of collagen-induced arthritis rats |
| title_sort | curcumin minimises histopathological and immunological progression in the ankle joints of collagen-induced arthritis rats |
| url | http://journalarticle.ukm.my/16267/ http://journalarticle.ukm.my/16267/ http://journalarticle.ukm.my/16267/1/5_ms0390_pdf_82104.pdf |