Curcumin minimises histopathological and immunological progression in the ankle joints of collagen-induced arthritis rats
Curcumin is a traditionally used spice with a potential to treat various inflammatory diseases including arthritis. This study was aimed at observing curcumin’s effects on the histopathological progression and interleukin-1β (IL-1β) levels in collagen�induced arthritis (CIA). Thirty male Sprague...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pusat Perubatan Universiti Kebangsaan Malaysia
2020
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| Online Access: | http://journalarticle.ukm.my/16267/ http://journalarticle.ukm.my/16267/1/5_ms0390_pdf_82104.pdf |
| Summary: | Curcumin is a traditionally used spice with a potential to treat various inflammatory
diseases including arthritis. This study was aimed at observing curcumin’s effects
on the histopathological progression and interleukin-1β (IL-1β) levels in collagen�induced arthritis (CIA). Thirty male Sprague-Dawley rats (150+50 g) were divided
into five random groups. A group was assigned as the normal control (CTRL),
while the remaining were subcutaneously immunised with 150 µg of collagen
emulsion on day 0. CTRL and CIA-Curcumin-d0 groups were supplemented daily
with olive oil (1 ml/kg) and curcumin (110 mg/ml/kg) from day 0, respectively. The
CIA-OV (negative control), CIA-Beta and CIA-Curcumin-d14 groups were given
daily supplementation of olive oil (1 ml/kg), Betamethasone (0.5 mg/ml/kg), and
curcumin (110 mg/ml/kg) from day 14, respectively. The daily oral supplementations
continued until day 42. The study showed that CIA-Beta (**P<0.05) and CIA�Curcumin-d0 (**P=0.01) groups had significantly lower mean histological scores
compared to CIA-OV, respectively. Serum IL-1β levels for CIA-Beta and CIA�Curcumin-d0 were not significantly raised on day 42 as to compared to day 0, and
the mean increment of IL-1β levels from day 0 to day 42 were significantly lower
(**P≤0.01) for all the CIA groups compared to CIA-OV. There was no significant
difference in both mean histological scores and IL-1β levels of CIA-Curcumin-d0
compared to CIA-Beta. Early supplementation of curcumin could potentially
minimise disease progression of CIA in rats. |
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