Enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review
The separation of azole antifungal chiral compounds has gaining much interests since 1980’s as they possess different biological, pharmaceutical, and pharmacokinetic behaviors at various toxicity levels. Numerous studies have looked into this subject matter, and therefore, this review presents an...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2020
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| Online Access: | http://journalarticle.ukm.my/16000/ http://journalarticle.ukm.my/16000/1/9.pdf |
| _version_ | 1848813939026034688 |
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| author | Nurul Raihana Azhari, Boon, Yih Hui Nur Nadhirah Mohamad Zain, Faiz Bukhari Mohd Suah, Sharifah Mohamad, Noorfatimah Yahaya, Muggundha Raoov, |
| author_facet | Nurul Raihana Azhari, Boon, Yih Hui Nur Nadhirah Mohamad Zain, Faiz Bukhari Mohd Suah, Sharifah Mohamad, Noorfatimah Yahaya, Muggundha Raoov, |
| author_sort | Nurul Raihana Azhari, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | The separation of azole antifungal chiral compounds has gaining much interests since 1980’s as they possess different
biological, pharmaceutical, and pharmacokinetic behaviors at various toxicity levels. Numerous studies have looked
into this subject matter, and therefore, this review presents an overview on different chiral separation techniques that
have been developed such as liquid chromatography (LC), gas chromatography (GC), supercritical fluid chromatography
(SFC), and capillary electrophoresis (CE). This comprehensive review also discusses the mechanisms of the developed
analytical methods such as preparation techniques and optimization parameters towards the enantioseparation
performances as well as their advantages and drawbacks. Lastly, the conclusion and future directions of the chiral
separation, particularly for azole compounds are provided accordingly. |
| first_indexed | 2025-11-15T00:26:09Z |
| format | Article |
| id | oai:generic.eprints.org:16000 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:26:09Z |
| publishDate | 2020 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:160002020-12-17T04:53:52Z http://journalarticle.ukm.my/16000/ Enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review Nurul Raihana Azhari, Boon, Yih Hui Nur Nadhirah Mohamad Zain, Faiz Bukhari Mohd Suah, Sharifah Mohamad, Noorfatimah Yahaya, Muggundha Raoov, The separation of azole antifungal chiral compounds has gaining much interests since 1980’s as they possess different biological, pharmaceutical, and pharmacokinetic behaviors at various toxicity levels. Numerous studies have looked into this subject matter, and therefore, this review presents an overview on different chiral separation techniques that have been developed such as liquid chromatography (LC), gas chromatography (GC), supercritical fluid chromatography (SFC), and capillary electrophoresis (CE). This comprehensive review also discusses the mechanisms of the developed analytical methods such as preparation techniques and optimization parameters towards the enantioseparation performances as well as their advantages and drawbacks. Lastly, the conclusion and future directions of the chiral separation, particularly for azole compounds are provided accordingly. Penerbit Universiti Kebangsaan Malaysia 2020-11 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/16000/1/9.pdf Nurul Raihana Azhari, and Boon, Yih Hui and Nur Nadhirah Mohamad Zain, and Faiz Bukhari Mohd Suah, and Sharifah Mohamad, and Noorfatimah Yahaya, and Muggundha Raoov, (2020) Enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review. Sains Malaysiana, 49 (11). pp. 2699-2714. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid49bil11_2020/KandunganJilid49Bil11_2020.html |
| spellingShingle | Nurul Raihana Azhari, Boon, Yih Hui Nur Nadhirah Mohamad Zain, Faiz Bukhari Mohd Suah, Sharifah Mohamad, Noorfatimah Yahaya, Muggundha Raoov, Enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review |
| title | Enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review |
| title_full | Enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review |
| title_fullStr | Enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review |
| title_full_unstemmed | Enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review |
| title_short | Enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review |
| title_sort | enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review |
| url | http://journalarticle.ukm.my/16000/ http://journalarticle.ukm.my/16000/ http://journalarticle.ukm.my/16000/1/9.pdf |