Design, synthesis and biological evaluation of aminoalkylated chalcones as antimalarial agent

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Design, synthesis and biological evaluation of aminoalkylated chalcones as antimalarial agent

Aminoalkylated chalcone compounds (4a-4c) have been designed using Quantitative Structure-Activity Relationship (QSAR) analysis, synthesized and evaluated for their in vitro antimalarial activity. The best QSAR model obtained was log IC50 = 705.132 (qC7) - 65.573 (qC3) - 24.845 (qC4) - 4.634 (qC13...

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Bibliographic Details
Main Authors:	Syahri, Jufrizal, Nasution, Hasmalina, Nurohmah, Beta Achromi, Purwono, Bambang, Emmy Yuanita, Nur Hanis Zakaria, Nurul Izzaty Hassan
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2020
Online Access:	http://journalarticle.ukm.my/15997/ http://journalarticle.ukm.my/15997/1/6.pdf

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