Isatin endowed metal chelates as antibacterial and antifungal agents
A new series of 5-chloroindoline-2,3-dione (isatin) derived ligands (L1 )-(L4 ) were prepared by reacting isatin with various diamines such as ethane-1,2-diamine, propane-1,3-diamine, butane-1,4-diamine, and benzene-1,2-diamine in an equimolar ratio to give 3-[(2-aminoethyl)imino]-5-chloro-1,3-d...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2020
|
| Online Access: | http://journalarticle.ukm.my/15782/ http://journalarticle.ukm.my/15782/1/11.pdf |
| _version_ | 1848813882997473280 |
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| author | Khalid, Seher Sumrra, Sajjad Hussain Chohan, Zahid Hussain |
| author_facet | Khalid, Seher Sumrra, Sajjad Hussain Chohan, Zahid Hussain |
| author_sort | Khalid, Seher |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | A new series of 5-chloroindoline-2,3-dione (isatin) derived ligands (L1
)-(L4
) were prepared by reacting isatin with
various diamines such as ethane-1,2-diamine, propane-1,3-diamine, butane-1,4-diamine, and benzene-1,2-diamine
in an equimolar ratio to give 3-[(2-aminoethyl)imino]-5-chloro-1,3-dihydro-2H-indol-2-one (L1
), 3-[(3-aminopropyl)
imino]-5-chloro-1,3-dihydro-2H-indol-2-one (L2
), 3-[(4-aminobutyl)imino]-5-chloro-1,3-dihydro-2H-indol-2-one (L3
)
and 3-[(2-aminophenyl)imino]-5-chloro-1,3-dihydro-2H-indol-2-one (L4
). All ligands acted as tridentate possessing
three active sites, isatin-O, azomethine-N, and amino-N for binding with the metal atoms. The structures of the isatin
based Schiff bases were elucidated through their spectral (infrared, ultraviolet, nuclear magnetic resonance, and mass
spectra), physical (melting point and solubility) and analytical (C, N, H %) data. The prepared ligands were reacted
with Co(II), Ni(II), Cu(II), and Zn(II) transition metals in 1:2 molar ratio (metal:ligand) to form their complexes.
IR, UV, NMR, conductance, magnetic moment, and elemental analysis was used to characterize the metal complexes.
Metals based isatins were evaluated for their in-vitro antimicrobial properties against selected fungal and bacterial
species. The anti-bacterial and anti-fungal results showed the metal chelates to be more biologically active than their
parent uncomplexed ligands. |
| first_indexed | 2025-11-15T00:25:15Z |
| format | Article |
| id | oai:generic.eprints.org:15782 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:25:15Z |
| publishDate | 2020 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:157822020-11-22T15:18:49Z http://journalarticle.ukm.my/15782/ Isatin endowed metal chelates as antibacterial and antifungal agents Khalid, Seher Sumrra, Sajjad Hussain Chohan, Zahid Hussain A new series of 5-chloroindoline-2,3-dione (isatin) derived ligands (L1 )-(L4 ) were prepared by reacting isatin with various diamines such as ethane-1,2-diamine, propane-1,3-diamine, butane-1,4-diamine, and benzene-1,2-diamine in an equimolar ratio to give 3-[(2-aminoethyl)imino]-5-chloro-1,3-dihydro-2H-indol-2-one (L1 ), 3-[(3-aminopropyl) imino]-5-chloro-1,3-dihydro-2H-indol-2-one (L2 ), 3-[(4-aminobutyl)imino]-5-chloro-1,3-dihydro-2H-indol-2-one (L3 ) and 3-[(2-aminophenyl)imino]-5-chloro-1,3-dihydro-2H-indol-2-one (L4 ). All ligands acted as tridentate possessing three active sites, isatin-O, azomethine-N, and amino-N for binding with the metal atoms. The structures of the isatin based Schiff bases were elucidated through their spectral (infrared, ultraviolet, nuclear magnetic resonance, and mass spectra), physical (melting point and solubility) and analytical (C, N, H %) data. The prepared ligands were reacted with Co(II), Ni(II), Cu(II), and Zn(II) transition metals in 1:2 molar ratio (metal:ligand) to form their complexes. IR, UV, NMR, conductance, magnetic moment, and elemental analysis was used to characterize the metal complexes. Metals based isatins were evaluated for their in-vitro antimicrobial properties against selected fungal and bacterial species. The anti-bacterial and anti-fungal results showed the metal chelates to be more biologically active than their parent uncomplexed ligands. Penerbit Universiti Kebangsaan Malaysia 2020-08 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/15782/1/11.pdf Khalid, Seher and Sumrra, Sajjad Hussain and Chohan, Zahid Hussain (2020) Isatin endowed metal chelates as antibacterial and antifungal agents. Sains Malaysiana, 49 (8). pp. 1891-1904. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid49bil8_2020/KandunganJilid49Bil8_2020.html |
| spellingShingle | Khalid, Seher Sumrra, Sajjad Hussain Chohan, Zahid Hussain Isatin endowed metal chelates as antibacterial and antifungal agents |
| title | Isatin endowed metal chelates as antibacterial and antifungal agents |
| title_full | Isatin endowed metal chelates as antibacterial and antifungal agents |
| title_fullStr | Isatin endowed metal chelates as antibacterial and antifungal agents |
| title_full_unstemmed | Isatin endowed metal chelates as antibacterial and antifungal agents |
| title_short | Isatin endowed metal chelates as antibacterial and antifungal agents |
| title_sort | isatin endowed metal chelates as antibacterial and antifungal agents |
| url | http://journalarticle.ukm.my/15782/ http://journalarticle.ukm.my/15782/ http://journalarticle.ukm.my/15782/1/11.pdf |