Organic extracts of Asian plants potentially support thrombolysis in varied BMI groups
A number of plant-derived drugs have been prescribed for treating atherothrombotic disorders such as myocardial or cerebral infarction. Therefore, this study investigated the individual and combined antithrombotic effects of six Asian plants on individuals with various BMIs. Venous blood drawn fro...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2020
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| Online Access: | http://journalarticle.ukm.my/15629/ http://journalarticle.ukm.my/15629/1/18.pdf |
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| author | Kabir, Md. Imtiazul Rahman, Md. Mominur Rahman, Md. Atiar Kamal, A.T.M. Mostafa Md. Adnan, Auniq, Reedwan Zafar Uddin Chy, Md. Nazim Hasan, Md. Mehedi Haque, Md. Areeful Bhuiyan, M. Mosharef Hossain Dina Hajjar, Makki, Arwa A. Alelwani, Walla |
| author_facet | Kabir, Md. Imtiazul Rahman, Md. Mominur Rahman, Md. Atiar Kamal, A.T.M. Mostafa Md. Adnan, Auniq, Reedwan Zafar Uddin Chy, Md. Nazim Hasan, Md. Mehedi Haque, Md. Areeful Bhuiyan, M. Mosharef Hossain Dina Hajjar, Makki, Arwa A. Alelwani, Walla |
| author_sort | Kabir, Md. Imtiazul |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | A number of plant-derived drugs have been prescribed for treating atherothrombotic disorders such as myocardial or
cerebral infarction. Therefore, this study investigated the individual and combined antithrombotic effects of six Asian
plants on individuals with various BMIs. Venous blood drawn from healthy volunteers was allowed to form clots and
treated with six organic fractions of Ophiorrhiza harrisiana Heyne, Haldina cordifolia (Roxb.) Ridsdale, Eclipta alba
(L.) Hassk, Syzygium operculatum L., Lantana camara L., and Acanthus ilicifolius Linn. using the clot-lysis method.
The weight of the clot before and after treatment provided the percentage of clot lysis. Variations in clot lysis in
different BMI groups were assessed. A. ilicifolius induced the most thrombolytic activity, whereas L. camara showed
slightly lower thrombolytic activity. The maximum clot-lysis activity was primarily observed in different fractions of
O. harrisana, H. cordifolia, E. alba, S. operculatum, and A. ilicifolius. However, chloroform fractions of all plants
except O. harrisana and L. camara showed maximum activity in individual plants. O. harrisana, H. cordifolia, E.
alba, S. operculatum, L. camara, and A. ilicifolius showed the highest significant (P < 0.5 and P < 0.001) clotlysis activity viz., 46.60±0.79% (ethyl acetate), 55.40±1.023% (chloroform), 48.86±1.35% (CCl4
), 44.89±1.76%
(chloroform), 29.17±1.12% (ethanol), and 56.318±1.64% (chloroform). Obtained results were verified by ligandreceptor interaction through in silico approach. In conclusion, H. cordifolia, E. alba, and A. ilicifolius demonstrated
promising thrombolytic effects; therefore, it is recommended that they be studied further for their therapeutic potential. |
| first_indexed | 2025-11-15T00:24:39Z |
| format | Article |
| id | oai:generic.eprints.org:15629 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:24:39Z |
| publishDate | 2020 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:156292020-11-11T16:42:22Z http://journalarticle.ukm.my/15629/ Organic extracts of Asian plants potentially support thrombolysis in varied BMI groups Kabir, Md. Imtiazul Rahman, Md. Mominur Rahman, Md. Atiar Kamal, A.T.M. Mostafa Md. Adnan, Auniq, Reedwan Zafar Uddin Chy, Md. Nazim Hasan, Md. Mehedi Haque, Md. Areeful Bhuiyan, M. Mosharef Hossain Dina Hajjar, Makki, Arwa A. Alelwani, Walla A number of plant-derived drugs have been prescribed for treating atherothrombotic disorders such as myocardial or cerebral infarction. Therefore, this study investigated the individual and combined antithrombotic effects of six Asian plants on individuals with various BMIs. Venous blood drawn from healthy volunteers was allowed to form clots and treated with six organic fractions of Ophiorrhiza harrisiana Heyne, Haldina cordifolia (Roxb.) Ridsdale, Eclipta alba (L.) Hassk, Syzygium operculatum L., Lantana camara L., and Acanthus ilicifolius Linn. using the clot-lysis method. The weight of the clot before and after treatment provided the percentage of clot lysis. Variations in clot lysis in different BMI groups were assessed. A. ilicifolius induced the most thrombolytic activity, whereas L. camara showed slightly lower thrombolytic activity. The maximum clot-lysis activity was primarily observed in different fractions of O. harrisana, H. cordifolia, E. alba, S. operculatum, and A. ilicifolius. However, chloroform fractions of all plants except O. harrisana and L. camara showed maximum activity in individual plants. O. harrisana, H. cordifolia, E. alba, S. operculatum, L. camara, and A. ilicifolius showed the highest significant (P < 0.5 and P < 0.001) clotlysis activity viz., 46.60±0.79% (ethyl acetate), 55.40±1.023% (chloroform), 48.86±1.35% (CCl4 ), 44.89±1.76% (chloroform), 29.17±1.12% (ethanol), and 56.318±1.64% (chloroform). Obtained results were verified by ligandreceptor interaction through in silico approach. In conclusion, H. cordifolia, E. alba, and A. ilicifolius demonstrated promising thrombolytic effects; therefore, it is recommended that they be studied further for their therapeutic potential. Penerbit Universiti Kebangsaan Malaysia 2020-07 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/15629/1/18.pdf Kabir, Md. Imtiazul and Rahman, Md. Mominur and Rahman, Md. Atiar and Kamal, A.T.M. Mostafa and Md. Adnan, and Auniq, Reedwan Zafar and Uddin Chy, Md. Nazim and Hasan, Md. Mehedi and Haque, Md. Areeful and Bhuiyan, M. Mosharef Hossain and Dina Hajjar, and Makki, Arwa A. and Alelwani, Walla (2020) Organic extracts of Asian plants potentially support thrombolysis in varied BMI groups. Sains Malaysiana, 49 (7). pp. 1669-1686. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid49bil7_2020/KandunganJilid49Bil7_2020.html |
| spellingShingle | Kabir, Md. Imtiazul Rahman, Md. Mominur Rahman, Md. Atiar Kamal, A.T.M. Mostafa Md. Adnan, Auniq, Reedwan Zafar Uddin Chy, Md. Nazim Hasan, Md. Mehedi Haque, Md. Areeful Bhuiyan, M. Mosharef Hossain Dina Hajjar, Makki, Arwa A. Alelwani, Walla Organic extracts of Asian plants potentially support thrombolysis in varied BMI groups |
| title | Organic extracts of Asian plants potentially support thrombolysis in varied BMI groups |
| title_full | Organic extracts of Asian plants potentially support thrombolysis in varied BMI groups |
| title_fullStr | Organic extracts of Asian plants potentially support thrombolysis in varied BMI groups |
| title_full_unstemmed | Organic extracts of Asian plants potentially support thrombolysis in varied BMI groups |
| title_short | Organic extracts of Asian plants potentially support thrombolysis in varied BMI groups |
| title_sort | organic extracts of asian plants potentially support thrombolysis in varied bmi groups |
| url | http://journalarticle.ukm.my/15629/ http://journalarticle.ukm.my/15629/ http://journalarticle.ukm.my/15629/1/18.pdf |