Correlation of rheumatoid factor serotypes and computed tomography findings in rheumatoid arthritis related interstitial lung disease
The most common extra-articular manifestation of rheumatoid arthritis (RA) is interstitial lung disease (ILD). RA related ILD (RA-ILD) is associated with significant morbidity and mortality. The main objective of this study was to determine the correlation between the rheumatoid factor (RF) seroty...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Pusat Perubatan Universiti Kebangsaan Malaysia
2019
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| Online Access: | http://journalarticle.ukm.my/15561/ http://journalarticle.ukm.my/15561/1/18_ms0331_pdf_13958.pdf |
| _version_ | 1848813827140878336 |
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| author | Sakthiswary Rajalingham, Radhika S, Syahrul Sazliyana Shaharir, Abdul Wahab A, |
| author_facet | Sakthiswary Rajalingham, Radhika S, Syahrul Sazliyana Shaharir, Abdul Wahab A, |
| author_sort | Sakthiswary Rajalingham, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | The most common extra-articular manifestation of rheumatoid arthritis (RA) is
interstitial lung disease (ILD). RA related ILD (RA-ILD) is associated with significant
morbidity and mortality. The main objective of this study was to determine the correlation between the rheumatoid factor (RF) serotypes and the severity of RAILD based on computed tomography (CT) findings. We recruited a total of 100 RA
patients who were tested for IgA RF, IgG RF and IgM RF and had high resolution
CT chest performed. Seventy-two patients had ILD changes on HRCT of the chest
and were included in this study. We found that the the CT scores for ground glass
showed significant positive correlation with disease duration and IgA RF levels
whereas the fibrosis scores had significant relationship with multiple clinical
covariates i.e age, disease duration, IgA RF levels, IgG RF levels and anti-CCP
levels. On multivariate analysis, only IgA levels remained significantly (p<0.05,
standardized beta coefficient = 0.604) associated with the ground glass scores.
Regarding the fibrosis scores, IgA RF levels and age were independent predictors
based on multivariate analysis after adjusting for confounders, with p scores of
<0.05 and 0.02, respectively. In conclusion, the IgA RF was the only serotype
which was independently associated with the severity of RA-ILD. |
| first_indexed | 2025-11-15T00:24:22Z |
| format | Article |
| id | oai:generic.eprints.org:15561 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:24:22Z |
| publishDate | 2019 |
| publisher | Pusat Perubatan Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:155612020-11-04T16:20:56Z http://journalarticle.ukm.my/15561/ Correlation of rheumatoid factor serotypes and computed tomography findings in rheumatoid arthritis related interstitial lung disease Sakthiswary Rajalingham, Radhika S, Syahrul Sazliyana Shaharir, Abdul Wahab A, The most common extra-articular manifestation of rheumatoid arthritis (RA) is interstitial lung disease (ILD). RA related ILD (RA-ILD) is associated with significant morbidity and mortality. The main objective of this study was to determine the correlation between the rheumatoid factor (RF) serotypes and the severity of RAILD based on computed tomography (CT) findings. We recruited a total of 100 RA patients who were tested for IgA RF, IgG RF and IgM RF and had high resolution CT chest performed. Seventy-two patients had ILD changes on HRCT of the chest and were included in this study. We found that the the CT scores for ground glass showed significant positive correlation with disease duration and IgA RF levels whereas the fibrosis scores had significant relationship with multiple clinical covariates i.e age, disease duration, IgA RF levels, IgG RF levels and anti-CCP levels. On multivariate analysis, only IgA levels remained significantly (p<0.05, standardized beta coefficient = 0.604) associated with the ground glass scores. Regarding the fibrosis scores, IgA RF levels and age were independent predictors based on multivariate analysis after adjusting for confounders, with p scores of <0.05 and 0.02, respectively. In conclusion, the IgA RF was the only serotype which was independently associated with the severity of RA-ILD. Pusat Perubatan Universiti Kebangsaan Malaysia 2019 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/15561/1/18_ms0331_pdf_13958.pdf Sakthiswary Rajalingham, and Radhika S, and Syahrul Sazliyana Shaharir, and Abdul Wahab A, (2019) Correlation of rheumatoid factor serotypes and computed tomography findings in rheumatoid arthritis related interstitial lung disease. Medicine & Health, 14 (2). pp. 203-211. ISSN 2289-5728 https://www.medicineandhealthukm.com/toc/14/2 |
| spellingShingle | Sakthiswary Rajalingham, Radhika S, Syahrul Sazliyana Shaharir, Abdul Wahab A, Correlation of rheumatoid factor serotypes and computed tomography findings in rheumatoid arthritis related interstitial lung disease |
| title | Correlation of rheumatoid factor serotypes and computed tomography findings in rheumatoid arthritis related interstitial lung disease |
| title_full | Correlation of rheumatoid factor serotypes and computed tomography findings in rheumatoid arthritis related interstitial lung disease |
| title_fullStr | Correlation of rheumatoid factor serotypes and computed tomography findings in rheumatoid arthritis related interstitial lung disease |
| title_full_unstemmed | Correlation of rheumatoid factor serotypes and computed tomography findings in rheumatoid arthritis related interstitial lung disease |
| title_short | Correlation of rheumatoid factor serotypes and computed tomography findings in rheumatoid arthritis related interstitial lung disease |
| title_sort | correlation of rheumatoid factor serotypes and computed tomography findings in rheumatoid arthritis related interstitial lung disease |
| url | http://journalarticle.ukm.my/15561/ http://journalarticle.ukm.my/15561/ http://journalarticle.ukm.my/15561/1/18_ms0331_pdf_13958.pdf |