The effects of virgin coconut oil on fibroblasts and myofibroblasts on diabetic wound healing
Delayed wound healing is one of the major complications of diabetes mellitus where it often leads to amputation. Virgin coconut oil (VCO) is a natural oil widely used to treat wounds and burns traditionally. It possesses potent antioxidant and antibacterial activities. This study aimed to determi...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pusat Perubatan Universiti Kebangsaan Malaysia
2019
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| Online Access: | http://journalarticle.ukm.my/15554/ http://journalarticle.ukm.my/15554/1/12_ms0310_pdf_90964.pdf |
| _version_ | 1848813825437990912 |
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| author | Wong, SK Rangiah T, Bakri NSA, Ismail WNA, Bojeng EEF, Abd Rahiman MA, Soliman AM, Ghafar N, Das S, Teoh, Seong Lin |
| author_facet | Wong, SK Rangiah T, Bakri NSA, Ismail WNA, Bojeng EEF, Abd Rahiman MA, Soliman AM, Ghafar N, Das S, Teoh, Seong Lin |
| author_sort | Wong, SK |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Delayed wound healing is one of the major complications of diabetes mellitus
where it often leads to amputation. Virgin coconut oil (VCO) is a natural oil widely
used to treat wounds and burns traditionally. It possesses potent antioxidant and
antibacterial activities. This study aimed to determine the effect of VCO on the
fibroblast population in diabetic wound healing. Full thickness cutaneous wound tissues were collected from non-treated, VCO-treated, and silver sulfadiazine (SS)-
treated diabetic rats. The tissues were then subjected to Verhoeff eosin staining and
immunohistology of fibroblast and myofibroblast. Histological analysis showed
increased collagen deposition with intact epidermis in the VCO treated group
compared to decreased collagen deposition with damaged epidermis in both nontreated and SS-treated groups. Interestingly, more fibroblasts and myofibroblasts
were observed in the non-treated group compared to the VCO- and SS-treated
groups. VCO significantly promoted wound healing process in diabetic rats via
promoting re-epithelialization, and increasing collagen fibres deposition and
wound contraction. The results suggested VCO can be used to treat diabetic
wounds. |
| first_indexed | 2025-11-15T00:24:21Z |
| format | Article |
| id | oai:generic.eprints.org:15554 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:24:21Z |
| publishDate | 2019 |
| publisher | Pusat Perubatan Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:155542020-11-04T16:09:25Z http://journalarticle.ukm.my/15554/ The effects of virgin coconut oil on fibroblasts and myofibroblasts on diabetic wound healing Wong, SK Rangiah T, Bakri NSA, Ismail WNA, Bojeng EEF, Abd Rahiman MA, Soliman AM, Ghafar N, Das S, Teoh, Seong Lin Delayed wound healing is one of the major complications of diabetes mellitus where it often leads to amputation. Virgin coconut oil (VCO) is a natural oil widely used to treat wounds and burns traditionally. It possesses potent antioxidant and antibacterial activities. This study aimed to determine the effect of VCO on the fibroblast population in diabetic wound healing. Full thickness cutaneous wound tissues were collected from non-treated, VCO-treated, and silver sulfadiazine (SS)- treated diabetic rats. The tissues were then subjected to Verhoeff eosin staining and immunohistology of fibroblast and myofibroblast. Histological analysis showed increased collagen deposition with intact epidermis in the VCO treated group compared to decreased collagen deposition with damaged epidermis in both nontreated and SS-treated groups. Interestingly, more fibroblasts and myofibroblasts were observed in the non-treated group compared to the VCO- and SS-treated groups. VCO significantly promoted wound healing process in diabetic rats via promoting re-epithelialization, and increasing collagen fibres deposition and wound contraction. The results suggested VCO can be used to treat diabetic wounds. Pusat Perubatan Universiti Kebangsaan Malaysia 2019 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/15554/1/12_ms0310_pdf_90964.pdf Wong, SK and Rangiah T, and Bakri NSA, and Ismail WNA, and Bojeng EEF, and Abd Rahiman MA, and Soliman AM, and Ghafar N, and Das S, and Teoh, Seong Lin (2019) The effects of virgin coconut oil on fibroblasts and myofibroblasts on diabetic wound healing. Medicine & Health, 14 (2). pp. 132-141. ISSN 2289-5728 https://www.medicineandhealthukm.com/toc/14/2 |
| spellingShingle | Wong, SK Rangiah T, Bakri NSA, Ismail WNA, Bojeng EEF, Abd Rahiman MA, Soliman AM, Ghafar N, Das S, Teoh, Seong Lin The effects of virgin coconut oil on fibroblasts and myofibroblasts on diabetic wound healing |
| title | The effects of virgin coconut oil on fibroblasts and myofibroblasts on diabetic wound healing |
| title_full | The effects of virgin coconut oil on fibroblasts and myofibroblasts on diabetic wound healing |
| title_fullStr | The effects of virgin coconut oil on fibroblasts and myofibroblasts on diabetic wound healing |
| title_full_unstemmed | The effects of virgin coconut oil on fibroblasts and myofibroblasts on diabetic wound healing |
| title_short | The effects of virgin coconut oil on fibroblasts and myofibroblasts on diabetic wound healing |
| title_sort | effects of virgin coconut oil on fibroblasts and myofibroblasts on diabetic wound healing |
| url | http://journalarticle.ukm.my/15554/ http://journalarticle.ukm.my/15554/ http://journalarticle.ukm.my/15554/1/12_ms0310_pdf_90964.pdf |