Characteristics and factors associated with adverse cutaneous drug reactions caused by traditional, complementary and conventional medicine in Malaysia
Traditional and Complimentary Medicines (TCMs) can potentially cause Adverse Cutaneous Drug Reactions (ACDRs). The aim of this study was to describe the characteristics of ACDRs due to TCMs and compare with those due to conventional medicine. This was a retrospective study with 134 cases being di...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pusat Perubatan Universiti Kebangsaan Malaysia
2019
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| Online Access: | http://journalarticle.ukm.my/15547/ http://journalarticle.ukm.my/15547/1/5_ms0279_pdf_60595.pdf |
| _version_ | 1848813823491833856 |
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| author | Nor Hazlin T, Leelavathi Muthupalaniappen, Zuhra Hamzah, Adawiyah Jamil, Dawn AA, |
| author_facet | Nor Hazlin T, Leelavathi Muthupalaniappen, Zuhra Hamzah, Adawiyah Jamil, Dawn AA, |
| author_sort | Nor Hazlin T, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Traditional and Complimentary Medicines (TCMs) can potentially cause Adverse
Cutaneous Drug Reactions (ACDRs). The aim of this study was to describe the
characteristics of ACDRs due to TCMs and compare with those due to conventional
medicine. This was a retrospective study with 134 cases being diagnosed with
ACDR at the Dermatology Clinic of a tertiary hospital in Kuala Lumpur. Most
(82.1%) ACDRs were caused by conventional drugs, while 17.9% were due
to TCMs. Majority (70-75%) of the ACDRs were of mild to moderate severity.
The most common ACDR to TCM was Exfoliative Dermatitis (ED) and Acute
Generalized Exanthematous Pustulosis (AGEP) (both 16.7%) while maculopapular
rash was the most common reaction for conventional medications (25.5%). The
onset of adverse reaction to TCM was about 4 weeks (60.2%) while reactions
due to conventional medication was earlier (1 to 6 days, 65.4%; p<0.05). The
odds of developing delayed ACDR was 14 times more with TCM compared to
conventional medicine (p<0.05). This study showed that ED and AGEP were the
most common ACDR manifestations of TCM while macuplopapular rash was the
most common manifestation of conventional medications. However, most of these
reactions were of mild to moderate severity. ACDR due to TCM may manifest long
after the initiation of these products and hence its use should be routinely inquired
when patients present with skin problems. All suspected cases of ADRs to TCM
should be reported to the Malaysian Adverse Drug Reactions Advisory Committee
(MADRAC) for continuous pharmacovigilance of these products. |
| first_indexed | 2025-11-15T00:24:19Z |
| format | Article |
| id | oai:generic.eprints.org:15547 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:24:19Z |
| publishDate | 2019 |
| publisher | Pusat Perubatan Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:155472020-11-04T15:37:59Z http://journalarticle.ukm.my/15547/ Characteristics and factors associated with adverse cutaneous drug reactions caused by traditional, complementary and conventional medicine in Malaysia Nor Hazlin T, Leelavathi Muthupalaniappen, Zuhra Hamzah, Adawiyah Jamil, Dawn AA, Traditional and Complimentary Medicines (TCMs) can potentially cause Adverse Cutaneous Drug Reactions (ACDRs). The aim of this study was to describe the characteristics of ACDRs due to TCMs and compare with those due to conventional medicine. This was a retrospective study with 134 cases being diagnosed with ACDR at the Dermatology Clinic of a tertiary hospital in Kuala Lumpur. Most (82.1%) ACDRs were caused by conventional drugs, while 17.9% were due to TCMs. Majority (70-75%) of the ACDRs were of mild to moderate severity. The most common ACDR to TCM was Exfoliative Dermatitis (ED) and Acute Generalized Exanthematous Pustulosis (AGEP) (both 16.7%) while maculopapular rash was the most common reaction for conventional medications (25.5%). The onset of adverse reaction to TCM was about 4 weeks (60.2%) while reactions due to conventional medication was earlier (1 to 6 days, 65.4%; p<0.05). The odds of developing delayed ACDR was 14 times more with TCM compared to conventional medicine (p<0.05). This study showed that ED and AGEP were the most common ACDR manifestations of TCM while macuplopapular rash was the most common manifestation of conventional medications. However, most of these reactions were of mild to moderate severity. ACDR due to TCM may manifest long after the initiation of these products and hence its use should be routinely inquired when patients present with skin problems. All suspected cases of ADRs to TCM should be reported to the Malaysian Adverse Drug Reactions Advisory Committee (MADRAC) for continuous pharmacovigilance of these products. Pusat Perubatan Universiti Kebangsaan Malaysia 2019 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/15547/1/5_ms0279_pdf_60595.pdf Nor Hazlin T, and Leelavathi Muthupalaniappen, and Zuhra Hamzah, and Adawiyah Jamil, and Dawn AA, (2019) Characteristics and factors associated with adverse cutaneous drug reactions caused by traditional, complementary and conventional medicine in Malaysia. Medicine & Health, 14 (2). pp. 50-59. ISSN 2289-5728 https://www.medicineandhealthukm.com/toc/14/2 |
| spellingShingle | Nor Hazlin T, Leelavathi Muthupalaniappen, Zuhra Hamzah, Adawiyah Jamil, Dawn AA, Characteristics and factors associated with adverse cutaneous drug reactions caused by traditional, complementary and conventional medicine in Malaysia |
| title | Characteristics and factors associated with adverse cutaneous drug reactions caused by traditional, complementary and conventional medicine in Malaysia |
| title_full | Characteristics and factors associated with adverse cutaneous drug reactions caused by traditional, complementary and conventional medicine in Malaysia |
| title_fullStr | Characteristics and factors associated with adverse cutaneous drug reactions caused by traditional, complementary and conventional medicine in Malaysia |
| title_full_unstemmed | Characteristics and factors associated with adverse cutaneous drug reactions caused by traditional, complementary and conventional medicine in Malaysia |
| title_short | Characteristics and factors associated with adverse cutaneous drug reactions caused by traditional, complementary and conventional medicine in Malaysia |
| title_sort | characteristics and factors associated with adverse cutaneous drug reactions caused by traditional, complementary and conventional medicine in malaysia |
| url | http://journalarticle.ukm.my/15547/ http://journalarticle.ukm.my/15547/ http://journalarticle.ukm.my/15547/1/5_ms0279_pdf_60595.pdf |