Role of novel therapeutic agents in modulating invadopodia formation in metastatic breast cancer
The ability to colonize distant organs which is lethal has made metastatic breast cancer become the top ten causes of mortality worldwide. Specialized actin-rich protrusions termed invadopodia were thought to be formed by highly invasive cells to degrade the extracellular matrix to drive cancer in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2020
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| Online Access: | http://journalarticle.ukm.my/15470/ http://journalarticle.ukm.my/15470/1/13.pdf |
| _version_ | 1848813808247635968 |
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| author | Siti Nor Aini Harun, Nurul Akmaryanti Abdullah, Noraina Muhamad Zakuan, Hafizah Abdul Hamid, Muhammad Zulfadli Mehat, Nur Fariesha Md Hashim, |
| author_facet | Siti Nor Aini Harun, Nurul Akmaryanti Abdullah, Noraina Muhamad Zakuan, Hafizah Abdul Hamid, Muhammad Zulfadli Mehat, Nur Fariesha Md Hashim, |
| author_sort | Siti Nor Aini Harun, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | The ability to colonize distant organs which is lethal has made metastatic breast cancer become the top ten causes
of mortality worldwide. Specialized actin-rich protrusions termed invadopodia were thought to be formed by highly
invasive cells to degrade the extracellular matrix to drive cancer invasion and metastasis. Identification of compound(s)
to hinder the formation ofinvadopodia is important to resist the metastasis of breast cancer as well as to yield antimetastasis targeted therapy. The current review aims to provide new insights on cancer invasion and candidate
compound(s) capable to disrupt invadopodia formation and invadopodia-related proteins. |
| first_indexed | 2025-11-15T00:24:04Z |
| format | Article |
| id | oai:generic.eprints.org:15470 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:24:04Z |
| publishDate | 2020 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:154702020-10-30T04:42:46Z http://journalarticle.ukm.my/15470/ Role of novel therapeutic agents in modulating invadopodia formation in metastatic breast cancer Siti Nor Aini Harun, Nurul Akmaryanti Abdullah, Noraina Muhamad Zakuan, Hafizah Abdul Hamid, Muhammad Zulfadli Mehat, Nur Fariesha Md Hashim, The ability to colonize distant organs which is lethal has made metastatic breast cancer become the top ten causes of mortality worldwide. Specialized actin-rich protrusions termed invadopodia were thought to be formed by highly invasive cells to degrade the extracellular matrix to drive cancer invasion and metastasis. Identification of compound(s) to hinder the formation ofinvadopodia is important to resist the metastasis of breast cancer as well as to yield antimetastasis targeted therapy. The current review aims to provide new insights on cancer invasion and candidate compound(s) capable to disrupt invadopodia formation and invadopodia-related proteins. Penerbit Universiti Kebangsaan Malaysia 2020-06 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/15470/1/13.pdf Siti Nor Aini Harun, and Nurul Akmaryanti Abdullah, and Noraina Muhamad Zakuan, and Hafizah Abdul Hamid, and Muhammad Zulfadli Mehat, and Nur Fariesha Md Hashim, (2020) Role of novel therapeutic agents in modulating invadopodia formation in metastatic breast cancer. Sains Malaysiana, 49 (6). pp. 1351-1358. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid49bil6_2020/KandunganJilid49Bil6_2020.html |
| spellingShingle | Siti Nor Aini Harun, Nurul Akmaryanti Abdullah, Noraina Muhamad Zakuan, Hafizah Abdul Hamid, Muhammad Zulfadli Mehat, Nur Fariesha Md Hashim, Role of novel therapeutic agents in modulating invadopodia formation in metastatic breast cancer |
| title | Role of novel therapeutic agents in modulating invadopodia formation in metastatic breast cancer |
| title_full | Role of novel therapeutic agents in modulating invadopodia formation in metastatic breast cancer |
| title_fullStr | Role of novel therapeutic agents in modulating invadopodia formation in metastatic breast cancer |
| title_full_unstemmed | Role of novel therapeutic agents in modulating invadopodia formation in metastatic breast cancer |
| title_short | Role of novel therapeutic agents in modulating invadopodia formation in metastatic breast cancer |
| title_sort | role of novel therapeutic agents in modulating invadopodia formation in metastatic breast cancer |
| url | http://journalarticle.ukm.my/15470/ http://journalarticle.ukm.my/15470/ http://journalarticle.ukm.my/15470/1/13.pdf |