Cytotoxic triterpenoids from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum against MCF-7 breast cancer cell
Three triterpenoids, taraxerone (1) and 18-epi-taraxerol (2), and masticadienolic acid (3) were isolated for the first time from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum, respectively. Isolation of the compounds was achieved by various extraction and chromatography column techn...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2020
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| Online Access: | http://journalarticle.ukm.my/15389/ http://journalarticle.ukm.my/15389/1/3.pdf |
| _version_ | 1848813788825911296 |
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| author | Achmad Zainuddin, Sylvia Rachmawati Meilanie, Darwati, Kurniawan, Nurlelasari, Tati Herlina, Saputra, Adrian Rizky Al Anshori, Jamaludin Tri Mayanti, |
| author_facet | Achmad Zainuddin, Sylvia Rachmawati Meilanie, Darwati, Kurniawan, Nurlelasari, Tati Herlina, Saputra, Adrian Rizky Al Anshori, Jamaludin Tri Mayanti, |
| author_sort | Achmad Zainuddin, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Three triterpenoids, taraxerone (1) and 18-epi-taraxerol (2), and masticadienolic acid (3) were isolated for the first time from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum, respectively. Isolation of the compounds was achieved by various extraction and chromatography column techniques, while their chemical structures were elucidated based on spectroscopic data and literature comparison. Compounds 1, 2, and 3 were found to show inhibitory activity against MCF-7 breast cancer cells with IC50 values 792.9, 59.6, and 3.5 µM correspondingly. |
| first_indexed | 2025-11-15T00:23:46Z |
| format | Article |
| id | oai:generic.eprints.org:15389 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:23:46Z |
| publishDate | 2020 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:153892020-10-23T00:45:01Z http://journalarticle.ukm.my/15389/ Cytotoxic triterpenoids from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum against MCF-7 breast cancer cell Achmad Zainuddin, Sylvia Rachmawati Meilanie, Darwati, Kurniawan, Nurlelasari, Tati Herlina, Saputra, Adrian Rizky Al Anshori, Jamaludin Tri Mayanti, Three triterpenoids, taraxerone (1) and 18-epi-taraxerol (2), and masticadienolic acid (3) were isolated for the first time from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum, respectively. Isolation of the compounds was achieved by various extraction and chromatography column techniques, while their chemical structures were elucidated based on spectroscopic data and literature comparison. Compounds 1, 2, and 3 were found to show inhibitory activity against MCF-7 breast cancer cells with IC50 values 792.9, 59.6, and 3.5 µM correspondingly. Penerbit Universiti Kebangsaan Malaysia 2020-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/15389/1/3.pdf Achmad Zainuddin, and Sylvia Rachmawati Meilanie, and Darwati, and Kurniawan, and Nurlelasari, and Tati Herlina, and Saputra, Adrian Rizky and Al Anshori, Jamaludin and Tri Mayanti, (2020) Cytotoxic triterpenoids from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum against MCF-7 breast cancer cell. Sains Malaysiana, 49 (5). pp. 989-994. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol49num5_2020/contentsVol49num5_2020.html |
| spellingShingle | Achmad Zainuddin, Sylvia Rachmawati Meilanie, Darwati, Kurniawan, Nurlelasari, Tati Herlina, Saputra, Adrian Rizky Al Anshori, Jamaludin Tri Mayanti, Cytotoxic triterpenoids from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum against MCF-7 breast cancer cell |
| title | Cytotoxic triterpenoids from the stem barks of Dysoxylum arborescens and
Dysoxylum excelsum against MCF-7 breast cancer cell |
| title_full | Cytotoxic triterpenoids from the stem barks of Dysoxylum arborescens and
Dysoxylum excelsum against MCF-7 breast cancer cell |
| title_fullStr | Cytotoxic triterpenoids from the stem barks of Dysoxylum arborescens and
Dysoxylum excelsum against MCF-7 breast cancer cell |
| title_full_unstemmed | Cytotoxic triterpenoids from the stem barks of Dysoxylum arborescens and
Dysoxylum excelsum against MCF-7 breast cancer cell |
| title_short | Cytotoxic triterpenoids from the stem barks of Dysoxylum arborescens and
Dysoxylum excelsum against MCF-7 breast cancer cell |
| title_sort | cytotoxic triterpenoids from the stem barks of dysoxylum arborescens and
dysoxylum excelsum against mcf-7 breast cancer cell |
| url | http://journalarticle.ukm.my/15389/ http://journalarticle.ukm.my/15389/ http://journalarticle.ukm.my/15389/1/3.pdf |