Impact of nitric oxide synthase 2 gene variant on risk of anti-tuberculosis drug- induced liver injury in the Malaysian population
Liver injury is a great threat associated with anti-tuberculosis (anti-TB) medication. Genetic variations in genes encoding drug-metabolising enzymes further enhance this threat. We aimed to explore genetic contributions by evaluating the impact of single nucleotide polymorphisms (SNPs) within the a...
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2020
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| Online Access: | http://journalarticle.ukm.my/14756/ http://journalarticle.ukm.my/14756/1/ARTIKEL%202.pdf |
| _version_ | 1848813634350743552 |
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| author | Vishala Sivapalan, Shamsul Mohd Zain, Jin, Shengnan Chan, Sze Ling Liu, Jiajun Zahurin Mohamed, Rosmawati Mohamed, |
| author_facet | Vishala Sivapalan, Shamsul Mohd Zain, Jin, Shengnan Chan, Sze Ling Liu, Jiajun Zahurin Mohamed, Rosmawati Mohamed, |
| author_sort | Vishala Sivapalan, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Liver injury is a great threat associated with anti-tuberculosis (anti-TB) medication. Genetic variations in genes encoding drug-metabolising enzymes further enhance this threat. We aimed to explore genetic contributions by evaluating the impact of single nucleotide polymorphisms (SNPs) within the anti-tuberculosis (AT) metabolism pathway genes and within their respective chromosomes on anti-tuberculosis drug- induced liver injury (AT-DILI). Patients (n= 90) were recruited and 170 SNPs were genotyped using Illumina array and validated using Sanger Sequencing. The well-studied N-acetyltransferase 2 (NAT2*6) rs1799930 and cytochrome P450 2E1 (CYP2E1) C1/C1 were not significantly associated with AT-DILI in our cohort but nitric oxide synthase (NOS2A) rs11080344-C was found to be significantly higher in the cases than the controls (OR 2.73, 95% CI 1.12-6.64, P= 0.027). Association studies on all other SNPs within the anti-tuberculosis metabolism pathway genes and within their respective chromosomes also found no significant report. Our study suggests that genetic variation in NOS2A could influence the occurrence of AT-DILI. |
| first_indexed | 2025-11-15T00:21:18Z |
| format | Article |
| id | oai:generic.eprints.org:14756 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:21:18Z |
| publishDate | 2020 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:147562020-06-22T07:42:58Z http://journalarticle.ukm.my/14756/ Impact of nitric oxide synthase 2 gene variant on risk of anti-tuberculosis drug- induced liver injury in the Malaysian population Vishala Sivapalan, Shamsul Mohd Zain, Jin, Shengnan Chan, Sze Ling Liu, Jiajun Zahurin Mohamed, Rosmawati Mohamed, Liver injury is a great threat associated with anti-tuberculosis (anti-TB) medication. Genetic variations in genes encoding drug-metabolising enzymes further enhance this threat. We aimed to explore genetic contributions by evaluating the impact of single nucleotide polymorphisms (SNPs) within the anti-tuberculosis (AT) metabolism pathway genes and within their respective chromosomes on anti-tuberculosis drug- induced liver injury (AT-DILI). Patients (n= 90) were recruited and 170 SNPs were genotyped using Illumina array and validated using Sanger Sequencing. The well-studied N-acetyltransferase 2 (NAT2*6) rs1799930 and cytochrome P450 2E1 (CYP2E1) C1/C1 were not significantly associated with AT-DILI in our cohort but nitric oxide synthase (NOS2A) rs11080344-C was found to be significantly higher in the cases than the controls (OR 2.73, 95% CI 1.12-6.64, P= 0.027). Association studies on all other SNPs within the anti-tuberculosis metabolism pathway genes and within their respective chromosomes also found no significant report. Our study suggests that genetic variation in NOS2A could influence the occurrence of AT-DILI. Penerbit Universiti Kebangsaan Malaysia 2020-02 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/14756/1/ARTIKEL%202.pdf Vishala Sivapalan, and Shamsul Mohd Zain, and Jin, Shengnan and Chan, Sze Ling and Liu, Jiajun and Zahurin Mohamed, and Rosmawati Mohamed, (2020) Impact of nitric oxide synthase 2 gene variant on risk of anti-tuberculosis drug- induced liver injury in the Malaysian population. Sains Malaysiana, 49 (2). pp. 237-248. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid49bil2_2020/KandunganJilid49Bil2_2020.html |
| spellingShingle | Vishala Sivapalan, Shamsul Mohd Zain, Jin, Shengnan Chan, Sze Ling Liu, Jiajun Zahurin Mohamed, Rosmawati Mohamed, Impact of nitric oxide synthase 2 gene variant on risk of anti-tuberculosis drug- induced liver injury in the Malaysian population |
| title | Impact of nitric oxide synthase 2 gene variant on risk of anti-tuberculosis drug- induced liver injury in the Malaysian population |
| title_full | Impact of nitric oxide synthase 2 gene variant on risk of anti-tuberculosis drug- induced liver injury in the Malaysian population |
| title_fullStr | Impact of nitric oxide synthase 2 gene variant on risk of anti-tuberculosis drug- induced liver injury in the Malaysian population |
| title_full_unstemmed | Impact of nitric oxide synthase 2 gene variant on risk of anti-tuberculosis drug- induced liver injury in the Malaysian population |
| title_short | Impact of nitric oxide synthase 2 gene variant on risk of anti-tuberculosis drug- induced liver injury in the Malaysian population |
| title_sort | impact of nitric oxide synthase 2 gene variant on risk of anti-tuberculosis drug- induced liver injury in the malaysian population |
| url | http://journalarticle.ukm.my/14756/ http://journalarticle.ukm.my/14756/ http://journalarticle.ukm.my/14756/1/ARTIKEL%202.pdf |