Current progress in production of flavonoids using systems and synthetic biology platforms
Flavonoid is an industrially-important compound due to its high pharmaceutical and cosmeceutical values. However, conventional methods in extracting and synthesizing flavonoids are costly, laborious and not sustainable due to small amount of natural flavonoids, large amounts of chemicals and space u...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2018
|
| Online Access: | http://journalarticle.ukm.my/12930/ http://journalarticle.ukm.my/12930/1/18%20Ku%20Nurul%20Aqmar%20Ku%20Bahaudin.pdf |
| _version_ | 1848813135710912512 |
|---|---|
| author | Ku Nurul Aqmar Ku Bahaudin, Suriana Sabri, Ahmad Bazli Ramzi, Leow Thean Chor, Adam Thean Chor Tewin Tencomnao, Syarul Nataqain Baharum, |
| author_facet | Ku Nurul Aqmar Ku Bahaudin, Suriana Sabri, Ahmad Bazli Ramzi, Leow Thean Chor, Adam Thean Chor Tewin Tencomnao, Syarul Nataqain Baharum, |
| author_sort | Ku Nurul Aqmar Ku Bahaudin, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Flavonoid is an industrially-important compound due to its high pharmaceutical and cosmeceutical values. However, conventional methods in extracting and synthesizing flavonoids are costly, laborious and not sustainable due to small amount of natural flavonoids, large amounts of chemicals and space used. Biotechnological production of flavonoids represents a viable and sustainable route especially through the use of metabolic engineering strategies in microbial production hosts. In this review, we will highlight recent strategies for the improving the production of flavonoids using synthetic biology approaches in particular the innovative strategies of genetically-encoded biosensors for in vivo metabolite analysis and high-throughput screening methods using fluorescence-activated cell sorting (FACS). Implementation of transcription factor based-biosensor for microbial flavonoid production and integration of systems and synthetic biology approaches for natural product development will also be discussed. |
| first_indexed | 2025-11-15T00:13:23Z |
| format | Article |
| id | oai:generic.eprints.org:12930 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:13:23Z |
| publishDate | 2018 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:129302019-05-15T11:09:17Z http://journalarticle.ukm.my/12930/ Current progress in production of flavonoids using systems and synthetic biology platforms Ku Nurul Aqmar Ku Bahaudin, Suriana Sabri, Ahmad Bazli Ramzi, Leow Thean Chor, Adam Thean Chor Tewin Tencomnao, Syarul Nataqain Baharum, Flavonoid is an industrially-important compound due to its high pharmaceutical and cosmeceutical values. However, conventional methods in extracting and synthesizing flavonoids are costly, laborious and not sustainable due to small amount of natural flavonoids, large amounts of chemicals and space used. Biotechnological production of flavonoids represents a viable and sustainable route especially through the use of metabolic engineering strategies in microbial production hosts. In this review, we will highlight recent strategies for the improving the production of flavonoids using synthetic biology approaches in particular the innovative strategies of genetically-encoded biosensors for in vivo metabolite analysis and high-throughput screening methods using fluorescence-activated cell sorting (FACS). Implementation of transcription factor based-biosensor for microbial flavonoid production and integration of systems and synthetic biology approaches for natural product development will also be discussed. Penerbit Universiti Kebangsaan Malaysia 2018-12 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12930/1/18%20Ku%20Nurul%20Aqmar%20Ku%20Bahaudin.pdf Ku Nurul Aqmar Ku Bahaudin, and Suriana Sabri, and Ahmad Bazli Ramzi, and Leow Thean Chor, Adam Thean Chor and Tewin Tencomnao, and Syarul Nataqain Baharum, (2018) Current progress in production of flavonoids using systems and synthetic biology platforms. Sains Malaysiana, 47 (12). pp. 3077-3084. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid47bil12_2018/KandunganJilid47Bil12_2018.html |
| spellingShingle | Ku Nurul Aqmar Ku Bahaudin, Suriana Sabri, Ahmad Bazli Ramzi, Leow Thean Chor, Adam Thean Chor Tewin Tencomnao, Syarul Nataqain Baharum, Current progress in production of flavonoids using systems and synthetic biology platforms |
| title | Current progress in production of flavonoids using systems
and synthetic biology platforms |
| title_full | Current progress in production of flavonoids using systems
and synthetic biology platforms |
| title_fullStr | Current progress in production of flavonoids using systems
and synthetic biology platforms |
| title_full_unstemmed | Current progress in production of flavonoids using systems
and synthetic biology platforms |
| title_short | Current progress in production of flavonoids using systems
and synthetic biology platforms |
| title_sort | current progress in production of flavonoids using systems
and synthetic biology platforms |
| url | http://journalarticle.ukm.my/12930/ http://journalarticle.ukm.my/12930/ http://journalarticle.ukm.my/12930/1/18%20Ku%20Nurul%20Aqmar%20Ku%20Bahaudin.pdf |