Appropriateness of Proton pump inhibitors prescription in patients admitted to a Malaysian tertiary hospital
Introduction Proton pump inhibitors (PPIs) are one of the commonest drug prescribed, however it is not without risk of adverse effects especially if the usage is inappropriate. We aimed to evaluate the frequency, indications and appropriateness of PPIs prescription among the medical inpatients, Ser...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2019
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| Online Access: | http://journalarticle.ukm.my/12714/ http://journalarticle.ukm.my/12714/1/226-1175-1-PB.pdf |
| _version_ | 1848813076820787200 |
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| author | Then, Ru Fah Tan, Yi Jun Pan, Yan Chieng, Jin Yu |
| author_facet | Then, Ru Fah Tan, Yi Jun Pan, Yan Chieng, Jin Yu |
| author_sort | Then, Ru Fah |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Introduction
Proton pump inhibitors (PPIs) are one of the commonest drug prescribed, however it is not without risk of adverse effects especially if the usage is inappropriate. We aimed to evaluate the frequency, indications and appropriateness of PPIs prescription among the medical inpatients, Serdang Hospital, which is a tertiary hospital in Malaysia.
Methods
This is a cross sectional study consisting of 1184 patients admitted to medical ward and received PPI from 1st July 2016 to 31st March 2017, and their database were further analysed by SPSS Statistics 17.0. Unpaired t-test was performed to analyze the data collected. P < 0.05 (two-tailed) is considered significant. Their indications were cross-referenced against the indications adapted from the United States Food and Drug Administration (FDA).
Results
About 23.9% (1184/4953) of inpatients were using PPIs, and 63.0% (746/1184) of them recently started on PPI in the ward, with mean age of 59.7 years. More male patients were commenced on PPIs during hospitalization (P value < 0.05). Based on the FDA guideline, only 21.8% patients were indicated, 32.2% were borderline indicated, and 46.0% patients were not indicated in prescribing PPIs. Stress ulcer prophylaxis was the commonest indication, while anaemia with no evidence of gastrointestinal bleed was the main non-indication in starting PPIs. Only 11% of patients had performed the oesophago-gastro-duodenoscopy (OGDS) during the hospital stay.
Conclusions
46.0% of inpatients were inappropriately prescribed PPIs according to FDA guideline. More efforts should be initiated to improve the current situation of PPIs overutilization in Malaysia. |
| first_indexed | 2025-11-15T00:12:27Z |
| format | Article |
| id | oai:generic.eprints.org:12714 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:12:27Z |
| publishDate | 2019 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:127142019-03-26T21:55:00Z http://journalarticle.ukm.my/12714/ Appropriateness of Proton pump inhibitors prescription in patients admitted to a Malaysian tertiary hospital Then, Ru Fah Tan, Yi Jun Pan, Yan Chieng, Jin Yu Introduction Proton pump inhibitors (PPIs) are one of the commonest drug prescribed, however it is not without risk of adverse effects especially if the usage is inappropriate. We aimed to evaluate the frequency, indications and appropriateness of PPIs prescription among the medical inpatients, Serdang Hospital, which is a tertiary hospital in Malaysia. Methods This is a cross sectional study consisting of 1184 patients admitted to medical ward and received PPI from 1st July 2016 to 31st March 2017, and their database were further analysed by SPSS Statistics 17.0. Unpaired t-test was performed to analyze the data collected. P < 0.05 (two-tailed) is considered significant. Their indications were cross-referenced against the indications adapted from the United States Food and Drug Administration (FDA). Results About 23.9% (1184/4953) of inpatients were using PPIs, and 63.0% (746/1184) of them recently started on PPI in the ward, with mean age of 59.7 years. More male patients were commenced on PPIs during hospitalization (P value < 0.05). Based on the FDA guideline, only 21.8% patients were indicated, 32.2% were borderline indicated, and 46.0% patients were not indicated in prescribing PPIs. Stress ulcer prophylaxis was the commonest indication, while anaemia with no evidence of gastrointestinal bleed was the main non-indication in starting PPIs. Only 11% of patients had performed the oesophago-gastro-duodenoscopy (OGDS) during the hospital stay. Conclusions 46.0% of inpatients were inappropriately prescribed PPIs according to FDA guideline. More efforts should be initiated to improve the current situation of PPIs overutilization in Malaysia. Penerbit Universiti Kebangsaan Malaysia 2019 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12714/1/226-1175-1-PB.pdf Then, Ru Fah and Tan, Yi Jun and Pan, Yan and Chieng, Jin Yu (2019) Appropriateness of Proton pump inhibitors prescription in patients admitted to a Malaysian tertiary hospital. International Journal of Public Health Research, 9 (1). pp. 1043-1050. ISSN 2232-0245 http://spaj.ukm.my/ijphr/index.php/ijphr/issue/view/24 |
| spellingShingle | Then, Ru Fah Tan, Yi Jun Pan, Yan Chieng, Jin Yu Appropriateness of Proton pump inhibitors prescription in patients admitted to a Malaysian tertiary hospital |
| title | Appropriateness of Proton pump inhibitors prescription in patients admitted to a Malaysian tertiary hospital |
| title_full | Appropriateness of Proton pump inhibitors prescription in patients admitted to a Malaysian tertiary hospital |
| title_fullStr | Appropriateness of Proton pump inhibitors prescription in patients admitted to a Malaysian tertiary hospital |
| title_full_unstemmed | Appropriateness of Proton pump inhibitors prescription in patients admitted to a Malaysian tertiary hospital |
| title_short | Appropriateness of Proton pump inhibitors prescription in patients admitted to a Malaysian tertiary hospital |
| title_sort | appropriateness of proton pump inhibitors prescription in patients admitted to a malaysian tertiary hospital |
| url | http://journalarticle.ukm.my/12714/ http://journalarticle.ukm.my/12714/ http://journalarticle.ukm.my/12714/1/226-1175-1-PB.pdf |