Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study
Fluid replacement is the mainstay treatment for diabetic ketoacidosis (DKA). Currently, the best choice of fluids is still debatable. An amount of 0.9% sodium chloride is commonly used. Sterofundin® is an alternative crystalloid that is assumed to expedite resolution of acidosis. Advantages in stero...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Pusat Perubatan Universiti Kebangsaan Malaysia
2017
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| Online Access: | http://journalarticle.ukm.my/12678/ http://journalarticle.ukm.my/12678/1/3_rossman_et_al_pdf_57811.pdf |
| _version_ | 1848813067875385344 |
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| author | Rossman H, Mahathar AW, Nik Azlan Nik Muhamad, |
| author_facet | Rossman H, Mahathar AW, Nik Azlan Nik Muhamad, |
| author_sort | Rossman H, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Fluid replacement is the mainstay treatment for diabetic ketoacidosis (DKA). Currently, the best choice of fluids is still debatable. An amount of 0.9% sodium chloride is commonly used. Sterofundin® is an alternative crystalloid that is assumed to expedite resolution of acidosis. Advantages in sterofundin content being smaller significant ion difference (SID) to plasma and lower chloride content. The main objective of the study was to compare rate of acidosis resolution in DKA patients between treatment with 0.9% normal saline and Sterofundin over 12 hrs. Other objectives were to compare significant ion difference (SID), 12-hr blood ketone clearance and electrolyte balance between the two groups. The study was a prospective open labelled randomized control trial. This study was conducted over 6 months. Sample size of 18 was obtained with 9 for each arm. Main difference between two groups was initial median 2-hr pH level improvement (NS = +0.006 vs. Sterofundin = +0.05, P=0.063), however not being significant. Ketone, anion gap reduction, bicarbonate normalisation, sodium, chloride, urea and creatinine levels failed to show any significant differences between both groups. Twelve-hour median chloride levels increments were higher in the NS group (+11) compared to the sterofundin group (+6). There was no difference between mortality and morbidity. Comparing the two fluid groups, there was no significant biochemical differences during treatment of DKA. This was a pilot study that can initiate further clinical trials. |
| first_indexed | 2025-11-15T00:12:18Z |
| format | Article |
| id | oai:generic.eprints.org:12678 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:12:18Z |
| publishDate | 2017 |
| publisher | Pusat Perubatan Universiti Kebangsaan Malaysia |
| recordtype | eprints |
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| spelling | oai:generic.eprints.org:126782019-03-17T12:03:50Z http://journalarticle.ukm.my/12678/ Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study Rossman H, Mahathar AW, Nik Azlan Nik Muhamad, Fluid replacement is the mainstay treatment for diabetic ketoacidosis (DKA). Currently, the best choice of fluids is still debatable. An amount of 0.9% sodium chloride is commonly used. Sterofundin® is an alternative crystalloid that is assumed to expedite resolution of acidosis. Advantages in sterofundin content being smaller significant ion difference (SID) to plasma and lower chloride content. The main objective of the study was to compare rate of acidosis resolution in DKA patients between treatment with 0.9% normal saline and Sterofundin over 12 hrs. Other objectives were to compare significant ion difference (SID), 12-hr blood ketone clearance and electrolyte balance between the two groups. The study was a prospective open labelled randomized control trial. This study was conducted over 6 months. Sample size of 18 was obtained with 9 for each arm. Main difference between two groups was initial median 2-hr pH level improvement (NS = +0.006 vs. Sterofundin = +0.05, P=0.063), however not being significant. Ketone, anion gap reduction, bicarbonate normalisation, sodium, chloride, urea and creatinine levels failed to show any significant differences between both groups. Twelve-hour median chloride levels increments were higher in the NS group (+11) compared to the sterofundin group (+6). There was no difference between mortality and morbidity. Comparing the two fluid groups, there was no significant biochemical differences during treatment of DKA. This was a pilot study that can initiate further clinical trials. Pusat Perubatan Universiti Kebangsaan Malaysia 2017 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12678/1/3_rossman_et_al_pdf_57811.pdf Rossman H, and Mahathar AW, and Nik Azlan Nik Muhamad, (2017) Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study. Medicine & Health, 12 (2). pp. 179-192. ISSN 2289-5728 http://www.medicineandhealthukm.com/toc/12/2 |
| spellingShingle | Rossman H, Mahathar AW, Nik Azlan Nik Muhamad, Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study |
| title | Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study |
| title_full | Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study |
| title_fullStr | Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study |
| title_full_unstemmed | Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study |
| title_short | Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study |
| title_sort | comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study |
| url | http://journalarticle.ukm.my/12678/ http://journalarticle.ukm.my/12678/ http://journalarticle.ukm.my/12678/1/3_rossman_et_al_pdf_57811.pdf |