(-)-glaciantarcin, a new dipeptide and some secondary metabolites from the psychrophilic yeast Glaciozyma antarctica PI12
A new dipeptide, (-)-glaciantarcin (1) and three known compounds, cyclo(-Pro-Gly) (2), 1-(2-deoxypentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione (3) and vidarabine (Ara-A) (4), were isolated from Glaciozyma antarctica PI12, a cold-adapted yeast. The chemical structures were elucidated by FT-IR,...
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2018
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| Online Access: | http://journalarticle.ukm.my/12650/ http://journalarticle.ukm.my/12650/1/12%20Andi%20R.%20Rosandy.pdf |
| _version_ | 1848813060395892736 |
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| author | Andi R. Rosandy, Yeoh, Chian Ying Cheah, Yoke Kqueen Seng, Joe Lim Jalifah Latip, Abdul Munir Abd. Murad, Muntaz Abu Bakar, Rozida Mohd. Khalid, |
| author_facet | Andi R. Rosandy, Yeoh, Chian Ying Cheah, Yoke Kqueen Seng, Joe Lim Jalifah Latip, Abdul Munir Abd. Murad, Muntaz Abu Bakar, Rozida Mohd. Khalid, |
| author_sort | Andi R. Rosandy, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | A new dipeptide, (-)-glaciantarcin (1) and three known compounds, cyclo(-Pro-Gly) (2), 1-(2-deoxypentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione (3) and vidarabine (Ara-A) (4), were isolated from Glaciozyma antarctica PI12, a cold-adapted yeast. The chemical structures were elucidated by FT-IR, NMR and mass spectrometry. The cytotoxicity and antioxidant activities of compounds 1-4 were evaluated by using the MTT bioassay on MCF-7 (human breast cancer cell line), PC-3 (human prostate cancer cell line) and HEK-293 (normal human embryonic kidney cell line) and DPPH free radical scavenging activity, respectively. At concentration of 400 μM, all compounds showed the highest activity on MCF-7, with compound 1 at 65%, compound 2 (70%), compound 3 (66%) and compound 4 (58%) cell viability. All compounds exhibited weak antioxidant properties. To the best of our knowledge, this is the first report of compounds 1-4 from Glaciozyma antactica. |
| first_indexed | 2025-11-15T00:12:11Z |
| format | Article |
| id | oai:generic.eprints.org:12650 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:12:11Z |
| publishDate | 2018 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:126502019-03-17T11:33:47Z http://journalarticle.ukm.my/12650/ (-)-glaciantarcin, a new dipeptide and some secondary metabolites from the psychrophilic yeast Glaciozyma antarctica PI12 Andi R. Rosandy, Yeoh, Chian Ying Cheah, Yoke Kqueen Seng, Joe Lim Jalifah Latip, Abdul Munir Abd. Murad, Muntaz Abu Bakar, Rozida Mohd. Khalid, A new dipeptide, (-)-glaciantarcin (1) and three known compounds, cyclo(-Pro-Gly) (2), 1-(2-deoxypentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione (3) and vidarabine (Ara-A) (4), were isolated from Glaciozyma antarctica PI12, a cold-adapted yeast. The chemical structures were elucidated by FT-IR, NMR and mass spectrometry. The cytotoxicity and antioxidant activities of compounds 1-4 were evaluated by using the MTT bioassay on MCF-7 (human breast cancer cell line), PC-3 (human prostate cancer cell line) and HEK-293 (normal human embryonic kidney cell line) and DPPH free radical scavenging activity, respectively. At concentration of 400 μM, all compounds showed the highest activity on MCF-7, with compound 1 at 65%, compound 2 (70%), compound 3 (66%) and compound 4 (58%) cell viability. All compounds exhibited weak antioxidant properties. To the best of our knowledge, this is the first report of compounds 1-4 from Glaciozyma antactica. Penerbit Universiti Kebangsaan Malaysia 2018-11 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12650/1/12%20Andi%20R.%20Rosandy.pdf Andi R. Rosandy, and Yeoh, Chian Ying and Cheah, Yoke Kqueen and Seng, Joe Lim and Jalifah Latip, and Abdul Munir Abd. Murad, and Muntaz Abu Bakar, and Rozida Mohd. Khalid, (2018) (-)-glaciantarcin, a new dipeptide and some secondary metabolites from the psychrophilic yeast Glaciozyma antarctica PI12. Sains Malaysiana, 47 (11). pp. 2693-2698. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid47bil11_2018/KandunganJilid47Bil11_2018.html |
| spellingShingle | Andi R. Rosandy, Yeoh, Chian Ying Cheah, Yoke Kqueen Seng, Joe Lim Jalifah Latip, Abdul Munir Abd. Murad, Muntaz Abu Bakar, Rozida Mohd. Khalid, (-)-glaciantarcin, a new dipeptide and some secondary metabolites from the psychrophilic yeast Glaciozyma antarctica PI12 |
| title | (-)-glaciantarcin, a new dipeptide and some secondary metabolites
from the psychrophilic yeast Glaciozyma antarctica PI12 |
| title_full | (-)-glaciantarcin, a new dipeptide and some secondary metabolites
from the psychrophilic yeast Glaciozyma antarctica PI12 |
| title_fullStr | (-)-glaciantarcin, a new dipeptide and some secondary metabolites
from the psychrophilic yeast Glaciozyma antarctica PI12 |
| title_full_unstemmed | (-)-glaciantarcin, a new dipeptide and some secondary metabolites
from the psychrophilic yeast Glaciozyma antarctica PI12 |
| title_short | (-)-glaciantarcin, a new dipeptide and some secondary metabolites
from the psychrophilic yeast Glaciozyma antarctica PI12 |
| title_sort | (-)-glaciantarcin, a new dipeptide and some secondary metabolites
from the psychrophilic yeast glaciozyma antarctica pi12 |
| url | http://journalarticle.ukm.my/12650/ http://journalarticle.ukm.my/12650/ http://journalarticle.ukm.my/12650/1/12%20Andi%20R.%20Rosandy.pdf |