Challenges in parathyroid cancers: a review
Parathyroid carcinomas are rare neoplasms, with a reported incidence of less than 1% of cases of primary hyperparathyroidism. Diagnosis and treatment of parathyroid carcinoma remains a challenge, as many of the pathologic features are neither sensitive nor specific in differentiating from benign par...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Pusat Perubatan Universiti Kebangsaan Malaysia
2018
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| Online Access: | http://journalarticle.ukm.my/12550/ http://journalarticle.ukm.my/12550/1/2._sujith__rajeev.pdf |
| _version_ | 1848813032734457856 |
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| author | Sujith Indeewara Wijerathne, Rajeev Parameswaran, |
| author_facet | Sujith Indeewara Wijerathne, Rajeev Parameswaran, |
| author_sort | Sujith Indeewara Wijerathne, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Parathyroid carcinomas are rare neoplasms, with a reported incidence of less than 1% of cases of primary hyperparathyroidism. Diagnosis and treatment of parathyroid carcinoma remains a challenge, as many of the pathologic features are neither sensitive nor specific in differentiating from benign parathyroid lesions. The rule of 3’s (serum calcium of more than 3mmol/L and size of the adenoma being more than 3cm) is helpful in risk identifying a cancer. Ultrasound of the neck and Tc-99m pertechnetate/Tc-99m sestamibi (MIBI) scan remains the two main modalities of investigation of parathyroid disease. Although en-bloc treatment is recommended for parathyroid cancer, it is only performed in up to 12% of cases. This review illustrates the challenges in diagnosis and treatment of parathyroid carcinoma. |
| first_indexed | 2025-11-15T00:11:45Z |
| format | Article |
| id | oai:generic.eprints.org:12550 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:11:45Z |
| publishDate | 2018 |
| publisher | Pusat Perubatan Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:125502019-02-14T13:51:52Z http://journalarticle.ukm.my/12550/ Challenges in parathyroid cancers: a review Sujith Indeewara Wijerathne, Rajeev Parameswaran, Parathyroid carcinomas are rare neoplasms, with a reported incidence of less than 1% of cases of primary hyperparathyroidism. Diagnosis and treatment of parathyroid carcinoma remains a challenge, as many of the pathologic features are neither sensitive nor specific in differentiating from benign parathyroid lesions. The rule of 3’s (serum calcium of more than 3mmol/L and size of the adenoma being more than 3cm) is helpful in risk identifying a cancer. Ultrasound of the neck and Tc-99m pertechnetate/Tc-99m sestamibi (MIBI) scan remains the two main modalities of investigation of parathyroid disease. Although en-bloc treatment is recommended for parathyroid cancer, it is only performed in up to 12% of cases. This review illustrates the challenges in diagnosis and treatment of parathyroid carcinoma. Pusat Perubatan Universiti Kebangsaan Malaysia 2018 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12550/1/2._sujith__rajeev.pdf Sujith Indeewara Wijerathne, and Rajeev Parameswaran, (2018) Challenges in parathyroid cancers: a review. Journal of Surgical Academia, 8 (1). pp. 5-15. ISSN 2231-7481 http://jsurgacad.com/toc/8/1 |
| spellingShingle | Sujith Indeewara Wijerathne, Rajeev Parameswaran, Challenges in parathyroid cancers: a review |
| title | Challenges in parathyroid cancers: a review |
| title_full | Challenges in parathyroid cancers: a review |
| title_fullStr | Challenges in parathyroid cancers: a review |
| title_full_unstemmed | Challenges in parathyroid cancers: a review |
| title_short | Challenges in parathyroid cancers: a review |
| title_sort | challenges in parathyroid cancers: a review |
| url | http://journalarticle.ukm.my/12550/ http://journalarticle.ukm.my/12550/ http://journalarticle.ukm.my/12550/1/2._sujith__rajeev.pdf |