Antihypertensive effect of Piper sarmentosum in L-NAME-induced hypertensive rats

Hypertension is one of the risk factors for cardiovascular diseases and has been associated with about 13% of global deaths worldwide. Oxidative stress and reduced nitric oxide (NO) bioavailability contribute to the development of endothelial dysfunction and subsequently hypertension. Nɷ-nitro-L-arg...

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Main Authors:	Nik Aloesnisa Nik Mohd Alwi, Zaiton Zakaria, Aminuddin Abdul Hamid Karim, Nor Anita Megat Mohd Nordin, Azizah Ugusman
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:	http://journalarticle.ukm.my/12511/ http://journalarticle.ukm.my/12511/1/18%20Nik%20Aloesnisa%20Nik%20Mohd%20Alwi.pdf

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author	Nik Aloesnisa Nik Mohd Alwi, Zaiton Zakaria, Aminuddin Abdul Hamid Karim, Nor Anita Megat Mohd Nordin, Azizah Ugusman,
author_facet	Nik Aloesnisa Nik Mohd Alwi, Zaiton Zakaria, Aminuddin Abdul Hamid Karim, Nor Anita Megat Mohd Nordin, Azizah Ugusman,
author_sort	Nik Aloesnisa Nik Mohd Alwi,
building	UKM Institutional Repository
collection	Online Access
description	Hypertension is one of the risk factors for cardiovascular diseases and has been associated with about 13% of global deaths worldwide. Oxidative stress and reduced nitric oxide (NO) bioavailability contribute to the development of endothelial dysfunction and subsequently hypertension. Nɷ-nitro-L-arginine methyl ester hydrochloride (L-NAME) inhibits NO synthesis; leading to hypertension. Piper sarmentosum (PS) is an herb with antioxidant, antiatherosclerosis and antiinflammation properties. PS also stimulated NO production by endothelial cells. The aim of this study was to determine the effects of aqueous extract of Piper sarmentosum (AEPS) on blood pressure, oxidative stress and the level of nitric oxide in L-NAME-induced hypertensive rats. Hypertension was induced by oral administration of L-NAME (100 mg/L) in drinking water for four weeks. The rats were concurrently treated with AEPS by oral gavage in serial doses (125, 250 and 500 mg/kg/day). Blood pressure was measured using non-invasive tail-cuff method at baseline and fortnightly thereafter. Serum level of NO and an oxidative stress marker, malondialdehyde (MDA) were measured at baseline and at the end of treatment. The results showed that treatment with three different doses of AEPS successfully reduced systolic blood pressure (p<0.001), diastolic blood pressure (p<0.05) and mean arterial pressure (p<0.05) in L-NAME-induced hypertensive rats. Treatment with AEPS also reduced MDA level (p<0.001) and increased serum NO (p<0.001) in L-NAME-induced hypertensive rats. The findings showed that AEPS decreased blood pressure by protecting against oxidative stress and increasing NO in L-NAME-induced hypertensive rats.
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id	oai:generic.eprints.org:12511
institution	Universiti Kebangasaan Malaysia
institution_category	Local University
language	English
last_indexed	2025-11-15T00:11:35Z
publishDate	2018
publisher	Penerbit Universiti Kebangsaan Malaysia
recordtype	eprints
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spelling	oai:generic.eprints.org:125112019-01-28T21:23:05Z http://journalarticle.ukm.my/12511/ Antihypertensive effect of Piper sarmentosum in L-NAME-induced hypertensive rats Nik Aloesnisa Nik Mohd Alwi, Zaiton Zakaria, Aminuddin Abdul Hamid Karim, Nor Anita Megat Mohd Nordin, Azizah Ugusman, Hypertension is one of the risk factors for cardiovascular diseases and has been associated with about 13% of global deaths worldwide. Oxidative stress and reduced nitric oxide (NO) bioavailability contribute to the development of endothelial dysfunction and subsequently hypertension. Nɷ-nitro-L-arginine methyl ester hydrochloride (L-NAME) inhibits NO synthesis; leading to hypertension. Piper sarmentosum (PS) is an herb with antioxidant, antiatherosclerosis and antiinflammation properties. PS also stimulated NO production by endothelial cells. The aim of this study was to determine the effects of aqueous extract of Piper sarmentosum (AEPS) on blood pressure, oxidative stress and the level of nitric oxide in L-NAME-induced hypertensive rats. Hypertension was induced by oral administration of L-NAME (100 mg/L) in drinking water for four weeks. The rats were concurrently treated with AEPS by oral gavage in serial doses (125, 250 and 500 mg/kg/day). Blood pressure was measured using non-invasive tail-cuff method at baseline and fortnightly thereafter. Serum level of NO and an oxidative stress marker, malondialdehyde (MDA) were measured at baseline and at the end of treatment. The results showed that treatment with three different doses of AEPS successfully reduced systolic blood pressure (p<0.001), diastolic blood pressure (p<0.05) and mean arterial pressure (p<0.05) in L-NAME-induced hypertensive rats. Treatment with AEPS also reduced MDA level (p<0.001) and increased serum NO (p<0.001) in L-NAME-induced hypertensive rats. The findings showed that AEPS decreased blood pressure by protecting against oxidative stress and increasing NO in L-NAME-induced hypertensive rats. Penerbit Universiti Kebangsaan Malaysia 2018-10 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12511/1/18%20Nik%20Aloesnisa%20Nik%20Mohd%20Alwi.pdf Nik Aloesnisa Nik Mohd Alwi, and Zaiton Zakaria, and Aminuddin Abdul Hamid Karim, and Nor Anita Megat Mohd Nordin, and Azizah Ugusman, (2018) Antihypertensive effect of Piper sarmentosum in L-NAME-induced hypertensive rats. Sains Malaysiana, 47 (10). pp. 2421-2428. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid47bil10_2018/KandunganJilid47Bil10_2018.htm
spellingShingle	Nik Aloesnisa Nik Mohd Alwi, Zaiton Zakaria, Aminuddin Abdul Hamid Karim, Nor Anita Megat Mohd Nordin, Azizah Ugusman, Antihypertensive effect of Piper sarmentosum in L-NAME-induced hypertensive rats
title	Antihypertensive effect of Piper sarmentosum in L-NAME-induced hypertensive rats
title_full	Antihypertensive effect of Piper sarmentosum in L-NAME-induced hypertensive rats
title_fullStr	Antihypertensive effect of Piper sarmentosum in L-NAME-induced hypertensive rats
title_full_unstemmed	Antihypertensive effect of Piper sarmentosum in L-NAME-induced hypertensive rats
title_short	Antihypertensive effect of Piper sarmentosum in L-NAME-induced hypertensive rats
title_sort	antihypertensive effect of piper sarmentosum in l-name-induced hypertensive rats
url	http://journalarticle.ukm.my/12511/ http://journalarticle.ukm.my/12511/ http://journalarticle.ukm.my/12511/1/18%20Nik%20Aloesnisa%20Nik%20Mohd%20Alwi.pdf

Antihypertensive effect of Piper sarmentosum in L-NAME-induced hypertensive rats

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