Neuroprotective effects of ethyl acetate extract of Zingiber zerumbet (L.) Smith against oxidative stress on paraquat-induced parkinsonism in rats
Zingiber zerumbet has been traditionally used as an anti-inflammation and antioxidant agent. The present study investigates the neuroprotective effects of ethyl acetate extract of Z. zerumbet against oxidative stress on paraquat (PQ)-induced Parkinsonism in rats. Forty male Sprague-Dawley rats were...
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2018
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| Online Access: | http://journalarticle.ukm.my/12503/ http://journalarticle.ukm.my/12503/1/10%20Farah%20Wahida%20Ibrahim.pdf |
| _version_ | 1848813020268986368 |
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| author | Farah Wahida Ibrahim, Umi Noraashikin Zainudin, Mazlyzam Abdul Latif, Asmah Hamid, |
| author_facet | Farah Wahida Ibrahim, Umi Noraashikin Zainudin, Mazlyzam Abdul Latif, Asmah Hamid, |
| author_sort | Farah Wahida Ibrahim, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Zingiber zerumbet has been traditionally used as an anti-inflammation and antioxidant agent. The present study investigates the neuroprotective effects of ethyl acetate extract of Z. zerumbet against oxidative stress on paraquat (PQ)-induced Parkinsonism in rats. Forty male Sprague-Dawley rats were divided into five groups: Negative control (normal saline), positive control (N-acetylcysteine, NAC 20 mg/kg + PQ 10 mg/kg), PQ only, 200 mg/kg Z. zerumbet + PQ and 400 mg/kg Z. zerumbet + PQ. The extract was given orally for 19 consecutive days and PQ was administered intraperitoneally on day 8-12th of the treatment regime. Both serum and fresh brains containing substantia nigra (SN) region were taken for biochemical and histological analysis. Administration of both 200 and 400 mg/kg ethyl acetate Z. zerumbet extracts to the PQ-treated groups have resulted in: Decreased levels of MDA and PC in the SN homogenates; and increased SOD, GPx; and CAT activities in the SN and serum. Overall, ethyl acetate extract of Z. zerumbet reduced oxidative stress in the SN of PQ-induced neuronal damages, therefore, has the potential to be developed as a preventive agent for neurodegenerative disorders caused by environmental toxins. |
| first_indexed | 2025-11-15T00:11:33Z |
| format | Article |
| id | oai:generic.eprints.org:12503 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:11:33Z |
| publishDate | 2018 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
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| spelling | oai:generic.eprints.org:125032019-01-28T15:19:13Z http://journalarticle.ukm.my/12503/ Neuroprotective effects of ethyl acetate extract of Zingiber zerumbet (L.) Smith against oxidative stress on paraquat-induced parkinsonism in rats Farah Wahida Ibrahim, Umi Noraashikin Zainudin, Mazlyzam Abdul Latif, Asmah Hamid, Zingiber zerumbet has been traditionally used as an anti-inflammation and antioxidant agent. The present study investigates the neuroprotective effects of ethyl acetate extract of Z. zerumbet against oxidative stress on paraquat (PQ)-induced Parkinsonism in rats. Forty male Sprague-Dawley rats were divided into five groups: Negative control (normal saline), positive control (N-acetylcysteine, NAC 20 mg/kg + PQ 10 mg/kg), PQ only, 200 mg/kg Z. zerumbet + PQ and 400 mg/kg Z. zerumbet + PQ. The extract was given orally for 19 consecutive days and PQ was administered intraperitoneally on day 8-12th of the treatment regime. Both serum and fresh brains containing substantia nigra (SN) region were taken for biochemical and histological analysis. Administration of both 200 and 400 mg/kg ethyl acetate Z. zerumbet extracts to the PQ-treated groups have resulted in: Decreased levels of MDA and PC in the SN homogenates; and increased SOD, GPx; and CAT activities in the SN and serum. Overall, ethyl acetate extract of Z. zerumbet reduced oxidative stress in the SN of PQ-induced neuronal damages, therefore, has the potential to be developed as a preventive agent for neurodegenerative disorders caused by environmental toxins. Penerbit Universiti Kebangsaan Malaysia 2018-10 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12503/1/10%20Farah%20Wahida%20Ibrahim.pdf Farah Wahida Ibrahim, and Umi Noraashikin Zainudin, and Mazlyzam Abdul Latif, and Asmah Hamid, (2018) Neuroprotective effects of ethyl acetate extract of Zingiber zerumbet (L.) Smith against oxidative stress on paraquat-induced parkinsonism in rats. Sains Malaysiana, 47 (10). pp. 2337-2347. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid47bil10_2018/KandunganJilid47Bil10_2018.htm |
| spellingShingle | Farah Wahida Ibrahim, Umi Noraashikin Zainudin, Mazlyzam Abdul Latif, Asmah Hamid, Neuroprotective effects of ethyl acetate extract of Zingiber zerumbet (L.) Smith against oxidative stress on paraquat-induced parkinsonism in rats |
| title | Neuroprotective effects of ethyl acetate extract of Zingiber zerumbet (L.) Smith against oxidative stress on paraquat-induced parkinsonism in rats |
| title_full | Neuroprotective effects of ethyl acetate extract of Zingiber zerumbet (L.) Smith against oxidative stress on paraquat-induced parkinsonism in rats |
| title_fullStr | Neuroprotective effects of ethyl acetate extract of Zingiber zerumbet (L.) Smith against oxidative stress on paraquat-induced parkinsonism in rats |
| title_full_unstemmed | Neuroprotective effects of ethyl acetate extract of Zingiber zerumbet (L.) Smith against oxidative stress on paraquat-induced parkinsonism in rats |
| title_short | Neuroprotective effects of ethyl acetate extract of Zingiber zerumbet (L.) Smith against oxidative stress on paraquat-induced parkinsonism in rats |
| title_sort | neuroprotective effects of ethyl acetate extract of zingiber zerumbet (l.) smith against oxidative stress on paraquat-induced parkinsonism in rats |
| url | http://journalarticle.ukm.my/12503/ http://journalarticle.ukm.my/12503/ http://journalarticle.ukm.my/12503/1/10%20Farah%20Wahida%20Ibrahim.pdf |