Optimisation of cinnamaldehyde-in-water nanoemulsion formulation using central composite rotatable design
Thirteen formulations of cinnamaldehyde/non-ionic surfactant/water system nanoemulsions were prepared using high-pressure homogenisation. The result showed that varying the cinnamaldehyde/surfactant ratio had effect significantly (p<0.05) to mean droplet diameter, polidispersity index, ζ-potentia...
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2018
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| Online Access: | http://journalarticle.ukm.my/12388/ http://journalarticle.ukm.my/12388/1/07%20Asmawati%20M.%20Sail.pdf |
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| author | Asmawati M. Sail, Wan Aida Wan Mustapha, Salma Mohamad Yusop, Mohamad Yusof Maskat, Ahmad Fuad Shamsuddin, |
| author_facet | Asmawati M. Sail, Wan Aida Wan Mustapha, Salma Mohamad Yusop, Mohamad Yusof Maskat, Ahmad Fuad Shamsuddin, |
| author_sort | Asmawati M. Sail, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Thirteen formulations of cinnamaldehyde/non-ionic surfactant/water system nanoemulsions were prepared using high-pressure homogenisation. The result showed that varying the cinnamaldehyde/surfactant ratio had effect significantly (p<0.05) to mean droplet diameter, polidispersity index, ζ-potential, turbidity and whiteness index, while no significant effect (p>0.05) to viscosity. The mean droplet diameter ranged from 50.48 to 106.4 nm, polydispersity index from 0.06 to 0.28 and ζ-potential from -4.11 to -6.98 mV. The smallest droplet size was produced using 5% cinnamaldehyde and 5% Tween 80. Response surface for droplet diameter showed that the higher the cinnamaldehyde and surfactant concentrations, the larger the droplet diameter, polydispersity index and whiteness index. However, the ζ-potential increased as the cinnamaldehyde concentration decreased and Tween 80 increased. Increasing the cinnamaldehyde concentration led to an increase in turbidity. Formulation of 5% cinnamaldehyde and 6.23% Tween 80 gave no observable separation of the nanoemulsion with minimum droplet size, polidispersity index, viscosity, turbidity, whiteness index and maximum ζ-potential in modulus. The stability of the optimum formulation was sustained for 10 days upon storage at 4°C. The values of droplet diameter, PDI and ζ-potential were 55.50 nm, 0.08 and -5.38 mV, respectively. |
| first_indexed | 2025-11-15T00:11:02Z |
| format | Article |
| id | oai:generic.eprints.org:12388 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:11:02Z |
| publishDate | 2018 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:123882018-12-07T23:21:35Z http://journalarticle.ukm.my/12388/ Optimisation of cinnamaldehyde-in-water nanoemulsion formulation using central composite rotatable design Asmawati M. Sail, Wan Aida Wan Mustapha, Salma Mohamad Yusop, Mohamad Yusof Maskat, Ahmad Fuad Shamsuddin, Thirteen formulations of cinnamaldehyde/non-ionic surfactant/water system nanoemulsions were prepared using high-pressure homogenisation. The result showed that varying the cinnamaldehyde/surfactant ratio had effect significantly (p<0.05) to mean droplet diameter, polidispersity index, ζ-potential, turbidity and whiteness index, while no significant effect (p>0.05) to viscosity. The mean droplet diameter ranged from 50.48 to 106.4 nm, polydispersity index from 0.06 to 0.28 and ζ-potential from -4.11 to -6.98 mV. The smallest droplet size was produced using 5% cinnamaldehyde and 5% Tween 80. Response surface for droplet diameter showed that the higher the cinnamaldehyde and surfactant concentrations, the larger the droplet diameter, polydispersity index and whiteness index. However, the ζ-potential increased as the cinnamaldehyde concentration decreased and Tween 80 increased. Increasing the cinnamaldehyde concentration led to an increase in turbidity. Formulation of 5% cinnamaldehyde and 6.23% Tween 80 gave no observable separation of the nanoemulsion with minimum droplet size, polidispersity index, viscosity, turbidity, whiteness index and maximum ζ-potential in modulus. The stability of the optimum formulation was sustained for 10 days upon storage at 4°C. The values of droplet diameter, PDI and ζ-potential were 55.50 nm, 0.08 and -5.38 mV, respectively. Penerbit Universiti Kebangsaan Malaysia 2018-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12388/1/07%20Asmawati%20M.%20Sail.pdf Asmawati M. Sail, and Wan Aida Wan Mustapha, and Salma Mohamad Yusop, and Mohamad Yusof Maskat, and Ahmad Fuad Shamsuddin, (2018) Optimisation of cinnamaldehyde-in-water nanoemulsion formulation using central composite rotatable design. Sains Malaysiana, 47 (9). pp. 1999-2008. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol47num9_2018/contentsVol47num9_2018.html |
| spellingShingle | Asmawati M. Sail, Wan Aida Wan Mustapha, Salma Mohamad Yusop, Mohamad Yusof Maskat, Ahmad Fuad Shamsuddin, Optimisation of cinnamaldehyde-in-water nanoemulsion formulation using central composite rotatable design |
| title | Optimisation of cinnamaldehyde-in-water nanoemulsion formulation
using central composite rotatable design |
| title_full | Optimisation of cinnamaldehyde-in-water nanoemulsion formulation
using central composite rotatable design |
| title_fullStr | Optimisation of cinnamaldehyde-in-water nanoemulsion formulation
using central composite rotatable design |
| title_full_unstemmed | Optimisation of cinnamaldehyde-in-water nanoemulsion formulation
using central composite rotatable design |
| title_short | Optimisation of cinnamaldehyde-in-water nanoemulsion formulation
using central composite rotatable design |
| title_sort | optimisation of cinnamaldehyde-in-water nanoemulsion formulation
using central composite rotatable design |
| url | http://journalarticle.ukm.my/12388/ http://journalarticle.ukm.my/12388/ http://journalarticle.ukm.my/12388/1/07%20Asmawati%20M.%20Sail.pdf |