Physicochemical and structural characterization of surface modified electrospun PMMA nanofibre
Although electrospun poly(methyl methacrylate) (PMMA) may mimic structural features of extracellular matrix, its highly hydrophobic nature causes reduced cell attachment. This study analysed the physicochemical and structural changes of the surface modified PMMA nanofiber. The electrospun PMMA nanof...
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2018
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| Online Access: | http://journalarticle.ukm.my/12200/ http://journalarticle.ukm.my/12200/1/17%20Rabiatul%20Adawiyah%20Razali.pdf |
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| author | Rabiatul Adawiyah Razali, Yogeswaran Lokanathan, Shiplu Roy Chowdhury, Aminuddin Saim, Ruszymah Haji Idrus, |
| author_facet | Rabiatul Adawiyah Razali, Yogeswaran Lokanathan, Shiplu Roy Chowdhury, Aminuddin Saim, Ruszymah Haji Idrus, |
| author_sort | Rabiatul Adawiyah Razali, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Although electrospun poly(methyl methacrylate) (PMMA) may mimic structural features of extracellular matrix, its highly hydrophobic nature causes reduced cell attachment. This study analysed the physicochemical and structural changes of the surface modified PMMA nanofiber. The electrospun PMMA nanofibers (PM) were surface-treated as follows: PM alone, collagen coated-PM (PM-C), UV-irradiated PM (PM-UV), collagen coated UV-irradiated PM (PM-C-UV) and collagen coated-PM crosslinked with genipin (PM-C-GEN). They were subjected to scanning electron microscopy, Fourier transform infrared (FTIR), cell attachment analysis, X-ray photoelectron spectroscopy (XPS), atomic force microscopy and X-ray powder diffraction (XRD). The surface roughness was lower in PM-C-UV group compared to others. Based on FTIR results, all expected functional group were present in all groups. XPS result showed that there are changes in the mass concentration of UV-treated surfaces and in the collagen coated surfaces. All PM groups showed amorphous nature through XRD. UV irradiation and collagen coating were shown to increase PM’s functional groups and modify its surface, which contributed to the increased attachment of cells onto the inert PM scaffold. As conclusion, collagen coated UV irradiated PMMA provided a better surface for cell to attach hence are suitable to be used further as scaffold for in vitro model. |
| first_indexed | 2025-11-15T00:10:14Z |
| format | Article |
| id | oai:generic.eprints.org:12200 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:10:14Z |
| publishDate | 2018 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:122002018-10-16T13:30:08Z http://journalarticle.ukm.my/12200/ Physicochemical and structural characterization of surface modified electrospun PMMA nanofibre Rabiatul Adawiyah Razali, Yogeswaran Lokanathan, Shiplu Roy Chowdhury, Aminuddin Saim, Ruszymah Haji Idrus, Although electrospun poly(methyl methacrylate) (PMMA) may mimic structural features of extracellular matrix, its highly hydrophobic nature causes reduced cell attachment. This study analysed the physicochemical and structural changes of the surface modified PMMA nanofiber. The electrospun PMMA nanofibers (PM) were surface-treated as follows: PM alone, collagen coated-PM (PM-C), UV-irradiated PM (PM-UV), collagen coated UV-irradiated PM (PM-C-UV) and collagen coated-PM crosslinked with genipin (PM-C-GEN). They were subjected to scanning electron microscopy, Fourier transform infrared (FTIR), cell attachment analysis, X-ray photoelectron spectroscopy (XPS), atomic force microscopy and X-ray powder diffraction (XRD). The surface roughness was lower in PM-C-UV group compared to others. Based on FTIR results, all expected functional group were present in all groups. XPS result showed that there are changes in the mass concentration of UV-treated surfaces and in the collagen coated surfaces. All PM groups showed amorphous nature through XRD. UV irradiation and collagen coating were shown to increase PM’s functional groups and modify its surface, which contributed to the increased attachment of cells onto the inert PM scaffold. As conclusion, collagen coated UV irradiated PMMA provided a better surface for cell to attach hence are suitable to be used further as scaffold for in vitro model. Penerbit Universiti Kebangsaan Malaysia 2018-08 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12200/1/17%20Rabiatul%20Adawiyah%20Razali.pdf Rabiatul Adawiyah Razali, and Yogeswaran Lokanathan, and Shiplu Roy Chowdhury, and Aminuddin Saim, and Ruszymah Haji Idrus, (2018) Physicochemical and structural characterization of surface modified electrospun PMMA nanofibre. Sains Malaysiana, 47 (8). pp. 1787-1794. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol47num8_2018/contentsVol47num8_2018.html |
| spellingShingle | Rabiatul Adawiyah Razali, Yogeswaran Lokanathan, Shiplu Roy Chowdhury, Aminuddin Saim, Ruszymah Haji Idrus, Physicochemical and structural characterization of surface modified electrospun PMMA nanofibre |
| title | Physicochemical and structural characterization of surface
modified electrospun PMMA nanofibre |
| title_full | Physicochemical and structural characterization of surface
modified electrospun PMMA nanofibre |
| title_fullStr | Physicochemical and structural characterization of surface
modified electrospun PMMA nanofibre |
| title_full_unstemmed | Physicochemical and structural characterization of surface
modified electrospun PMMA nanofibre |
| title_short | Physicochemical and structural characterization of surface
modified electrospun PMMA nanofibre |
| title_sort | physicochemical and structural characterization of surface
modified electrospun pmma nanofibre |
| url | http://journalarticle.ukm.my/12200/ http://journalarticle.ukm.my/12200/ http://journalarticle.ukm.my/12200/1/17%20Rabiatul%20Adawiyah%20Razali.pdf |