Observation of tumour-induced reorganization in structural and functional architecture of the brain in three pre-surgical patients with left frontal-temporal brain tumour: a combination of MEG, DTI and neuropsychological assessment
Visual function is mainly located within the bilateral hemisphere of the occipital lobes of the brain. However, our functional magnetoencephalography (MEG) result has demonstrated the reorganization of brain activity in the occipital area in patients with left-sided brain tumour. The results showed...
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2017
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| Online Access: | http://journalarticle.ukm.my/11547/ http://journalarticle.ukm.my/11547/1/26%20Hanani.pdf |
| _version_ | 1848812761630375936 |
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| author | Hanani Abdul Manan, Zamzuri Idris, Mohammed Faruque Reza, Wan Nor Azlen Wan Mohamad, Jafri Malin Abdullah, |
| author_facet | Hanani Abdul Manan, Zamzuri Idris, Mohammed Faruque Reza, Wan Nor Azlen Wan Mohamad, Jafri Malin Abdullah, |
| author_sort | Hanani Abdul Manan, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Visual function is mainly located within the bilateral hemisphere of the occipital lobes of the brain. However, our functional magnetoencephalography (MEG) result has demonstrated the reorganization of brain activity in the occipital area in patients with left-sided brain tumour. The results showed that brain laterality changes from bilateral to unilateral activation of the occipital area. Right occipital area (contralateral areas to the tumour), shows increase intensity of activation. Diffusion tensor imaging (DTI) with fibre tracking was performed to further investigate this brain laterality modification and the findings confirmed there is an alteration in the left hemisphere fibre optic tracts. This functional modification and changes of the brain laterality and optic tracts in the brain is suspected to be the result of tumour growth induced changes. The present observation will be discussed in term of the mechanism of tumour induced reorganization and changes with the corroborating evidence from MEG, DTI and neuropsychological assessment. |
| first_indexed | 2025-11-15T00:07:26Z |
| format | Article |
| id | oai:generic.eprints.org:11547 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:07:26Z |
| publishDate | 2017 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
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| spelling | oai:generic.eprints.org:115472018-04-10T10:03:13Z http://journalarticle.ukm.my/11547/ Observation of tumour-induced reorganization in structural and functional architecture of the brain in three pre-surgical patients with left frontal-temporal brain tumour: a combination of MEG, DTI and neuropsychological assessment Hanani Abdul Manan, Zamzuri Idris, Mohammed Faruque Reza, Wan Nor Azlen Wan Mohamad, Jafri Malin Abdullah, Visual function is mainly located within the bilateral hemisphere of the occipital lobes of the brain. However, our functional magnetoencephalography (MEG) result has demonstrated the reorganization of brain activity in the occipital area in patients with left-sided brain tumour. The results showed that brain laterality changes from bilateral to unilateral activation of the occipital area. Right occipital area (contralateral areas to the tumour), shows increase intensity of activation. Diffusion tensor imaging (DTI) with fibre tracking was performed to further investigate this brain laterality modification and the findings confirmed there is an alteration in the left hemisphere fibre optic tracts. This functional modification and changes of the brain laterality and optic tracts in the brain is suspected to be the result of tumour growth induced changes. The present observation will be discussed in term of the mechanism of tumour induced reorganization and changes with the corroborating evidence from MEG, DTI and neuropsychological assessment. Penerbit Universiti Kebangsaan Malaysia 2017-10 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/11547/1/26%20Hanani.pdf Hanani Abdul Manan, and Zamzuri Idris, and Mohammed Faruque Reza, and Wan Nor Azlen Wan Mohamad, and Jafri Malin Abdullah, (2017) Observation of tumour-induced reorganization in structural and functional architecture of the brain in three pre-surgical patients with left frontal-temporal brain tumour: a combination of MEG, DTI and neuropsychological assessment. Sains Malaysiana, 46 (10). pp. 1877-1886. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol46num10_2017/contentsVol46num10_2017.html |
| spellingShingle | Hanani Abdul Manan, Zamzuri Idris, Mohammed Faruque Reza, Wan Nor Azlen Wan Mohamad, Jafri Malin Abdullah, Observation of tumour-induced reorganization in structural and functional architecture of the brain in three pre-surgical patients with left frontal-temporal brain tumour: a combination of MEG, DTI and neuropsychological assessment |
| title | Observation of tumour-induced reorganization in structural and functional architecture of the brain in three pre-surgical patients with left frontal-temporal brain tumour: a combination of MEG, DTI and neuropsychological assessment |
| title_full | Observation of tumour-induced reorganization in structural and functional architecture of the brain in three pre-surgical patients with left frontal-temporal brain tumour: a combination of MEG, DTI and neuropsychological assessment |
| title_fullStr | Observation of tumour-induced reorganization in structural and functional architecture of the brain in three pre-surgical patients with left frontal-temporal brain tumour: a combination of MEG, DTI and neuropsychological assessment |
| title_full_unstemmed | Observation of tumour-induced reorganization in structural and functional architecture of the brain in three pre-surgical patients with left frontal-temporal brain tumour: a combination of MEG, DTI and neuropsychological assessment |
| title_short | Observation of tumour-induced reorganization in structural and functional architecture of the brain in three pre-surgical patients with left frontal-temporal brain tumour: a combination of MEG, DTI and neuropsychological assessment |
| title_sort | observation of tumour-induced reorganization in structural and functional architecture of the brain in three pre-surgical patients with left frontal-temporal brain tumour: a combination of meg, dti and neuropsychological assessment |
| url | http://journalarticle.ukm.my/11547/ http://journalarticle.ukm.my/11547/ http://journalarticle.ukm.my/11547/1/26%20Hanani.pdf |