Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients
The purpose of this study was to characterize, differentiate and correlate visual field and brain activation in visual cortex for normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) participants using Standard Automated Perimetry (SAP) and functional Magnetic Resonance Imaging (fMRI...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2017
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| Online Access: | http://journalarticle.ukm.my/11455/ http://journalarticle.ukm.my/11455/1/16741-47126-1-SM.pdf |
| _version_ | 1848812731755397120 |
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| author | Nurul Hanim Nasaruddin, Ahmad Nazlim Yusoff, Sharanjeet Kaur, |
| author_facet | Nurul Hanim Nasaruddin, Ahmad Nazlim Yusoff, Sharanjeet Kaur, |
| author_sort | Nurul Hanim Nasaruddin, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | The purpose of this study was to characterize, differentiate and correlate visual field and brain activation in visual cortex for normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) participants using Standard Automated Perimetry (SAP) and functional Magnetic Resonance Imaging (fMRI) respectively. The fMRI scans and SAP test were both carried out in Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM). Two types of black-and-white checkerboard pattern were displayed to the participants during the fMRI scans. The fMRI data were analyzed using WFU pickatlas toolbox targeting visual cortex area. The results showed that there was no significant difference in number of activated voxel between the three groups in visual cortex (BA 17, 18 and 19) while viewing all the given stimuli (p > 0.05). The pattern standard deviation (PSD) of SAP for visual field also revealed no significant differences (p > 0.05) in all groups of participants. However, negative correlation between PSD and fMRI activation was observed. The PSD values increased with a decrease in fMRI activation. With reference to visual field analysis, the results suggest that glaucomatous neuropathy of POAG patients has led to a gradual decrease in visual cortex activation and a gradual increase in PSD. |
| first_indexed | 2025-11-15T00:06:58Z |
| format | Article |
| id | oai:generic.eprints.org:11455 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:06:58Z |
| publishDate | 2017 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
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| spelling | oai:generic.eprints.org:114552018-03-16T01:05:58Z http://journalarticle.ukm.my/11455/ Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients Nurul Hanim Nasaruddin, Ahmad Nazlim Yusoff, Sharanjeet Kaur, The purpose of this study was to characterize, differentiate and correlate visual field and brain activation in visual cortex for normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) participants using Standard Automated Perimetry (SAP) and functional Magnetic Resonance Imaging (fMRI) respectively. The fMRI scans and SAP test were both carried out in Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM). Two types of black-and-white checkerboard pattern were displayed to the participants during the fMRI scans. The fMRI data were analyzed using WFU pickatlas toolbox targeting visual cortex area. The results showed that there was no significant difference in number of activated voxel between the three groups in visual cortex (BA 17, 18 and 19) while viewing all the given stimuli (p > 0.05). The pattern standard deviation (PSD) of SAP for visual field also revealed no significant differences (p > 0.05) in all groups of participants. However, negative correlation between PSD and fMRI activation was observed. The PSD values increased with a decrease in fMRI activation. With reference to visual field analysis, the results suggest that glaucomatous neuropathy of POAG patients has led to a gradual decrease in visual cortex activation and a gradual increase in PSD. Penerbit Universiti Kebangsaan Malaysia 2017 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/11455/1/16741-47126-1-SM.pdf Nurul Hanim Nasaruddin, and Ahmad Nazlim Yusoff, and Sharanjeet Kaur, (2017) Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients. Jurnal Sains Kesihatan Malaysia, 15 (1). pp. 27-32. ISSN 1675-8161 http://ejournal.ukm.my/jskm/issue/view/635 |
| spellingShingle | Nurul Hanim Nasaruddin, Ahmad Nazlim Yusoff, Sharanjeet Kaur, Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients |
| title | Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients |
| title_full | Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients |
| title_fullStr | Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients |
| title_full_unstemmed | Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients |
| title_short | Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients |
| title_sort | functional mri characteristics in visual cortex (ba 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (gs) and primary open angle glaucoma (poag) patients |
| url | http://journalarticle.ukm.my/11455/ http://journalarticle.ukm.my/11455/ http://journalarticle.ukm.my/11455/1/16741-47126-1-SM.pdf |