A gain of function p53 gene mutant promotes growth
suppression in human liver cancer cells

QR Code

A gain of function p53 gene mutant promotes growth suppression in human liver cancer cells

Primary liver cancer is one of the most common cancer in the world with highest cancer mortality rate. The most common type of primary liver cancer is hepatocellular carcinoma (HCC). There are many risk factors for liver cancer and currently available treatments for HCC are largely inadequate. Gene...

Full description

Bibliographic Details
Main Authors:	Nor Adzimah Johdi, Siti Nurmi Nasir, A. Rahman A. Jamal
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2017
Online Access:	http://journalarticle.ukm.my/11149/ http://journalarticle.ukm.my/11149/1/15%20Nor%20Adzimah%20Johdi.pdf

Similar Items

The relationship of P53 gene mutation with clinicopathological characteristic in breast cancer
by: Amrank, Fitreena Anis
Published: (2016)

Site-directed mutagenesis for the production of mutant TP53 gene and analysis of its tumor suppressor activity
by: Bakhtiar, M. Taher, et al.
Published: (2012)

The mutant p53-ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1
by: Pruszko, Magdalena, et al.
Published: (2017)

Redox regulation of p53, redox effectors regulated by p53: A subtle balance
by: Maillet, A., et al.
Published: (2012)

Suppression Effects of Pandanus Amarylfolius and Strobilanthes Cripus Extracts on the Growth of Breast Cancer Cells by Inducing p53-Mediated Apoptotic Pathway
by: Chong, Hueh Zan
Published: (2010)

Silencing endogenous mutant P53 Using Sirna Induces P73-Mediated Apoptosis in Human Head And Neck Squamous Cell Carcinoma
by: Arief Ichwan, Solachuddin Jauhari, et al.
Published: (2011)

Growth Suppression of non-small lung carcinoma cell H1299 transfected with p53 and p73beta
by: Hayati, Rahma Fitri, et al.
Published: (2010)

Growth suppression of non-small lung carcinoma cell H1299 transfected with p53 and p73B
by: Hayati, Rahma Fitri, et al.
Published: (2010)

Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient for p53Ser46 phosphorylation
by: Teng, Ma, et al.
Published: (2012)

Synergistic anti-cancer effects of recombinant adenoviruses DRIL1 and p53 gene transfer against human lung cancer cells
by: Arief Ichwan, Solachuddin Jauhari
Published: (2011)

Reverse Transcriptase in Situ Expression Patterns of P53, Cyclin E And Rb Genes at Different Stages of Breast Cancer
by: Zamanian, Mohammadreza
Published: (2007)

Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cells
by: Abdul Aziz, Muhammad Yusran, et al.
Published: (2014)

Defect in ser46 phosphorylation of p53 protein: a resistance mechanism against p53 gene transfer in oral squamos cell carcinoma cells
by: Arief Ichwan, Solachuddin Jauhari, et al.
Published: (2008)

Suppression Effect of Eurycomanone on the Growth of Human Hepatoma Cells (Hepg2) by Inducing P53-Mediated Apoptotic Pathway
by: Zakaria, Yusmazura
Published: (2009)

Expression of p53 protein in premenopausal women as risk factors for breast cancer
by: Rashidah S,, et al.
Published: (2016)

p53-targeted cancer pharmacotherapy: move towards small molecule compounds
by: Kim, S., et al.
Published: (2011)

Gene Expression And Metabonomic Profilings In P53+/- Knockout Mice Following Diethylstilbestrol Treatment
by: Salleh, Mohd Nazil
Published: (2003)

An associative study of the ribosomal protein genes, rps3 and rps2 with the p53 tumour suppressor gene
by: Ting, Chee Enn
Published: (2013)

Analysis of TP53 gene expression and p53 level of human hypopharyngeal FaDu (HTB-43) head and neck cancer cell line after microRNA-181a inhibition
by: Cheah, Yoke Kqueen, et al.
Published: (2014)

Analysis of sequencing in exon 8, 9 and 11 in human tumor suppressor gene, P53
by: Toh, Alan Kie Leong
Published: (2003)

Quantitative analysis of the expression of p53 gene in colorectal carcinoma by using real-time PCR
by: Bong, Ivyna Pau Ni, et al.
Published: (2006)

Analysis of the anti-cancer effect of ethyl-p-methoxycinnamate extracted cekur (Kaempferia galanga) on cancer cell lines with wild-type and null p53
by: Ichwan, Solachuddin J. A., et al.
Published: (2020)

Crosstalk between p53 and mitochondrial metabolism
by: Itahana, K., et al.
Published: (2014)

Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells
by: Arief Ichwan, Solachuddin Jauhari, et al.
Published: (2006)

Critical role of ARID3B in the expression of pro-apoptotic p53-target genes and apoptosis
by: Pratama, Endrawan, et al.
Published: (2015)

p53 protein expression and risk factors in breast cancer – a retrospective study / Rashidah Shahruddin
by: Shahruddin, Rashidah
Published: (2017)

The inter-relationship between p53, survivin and XIAP in colorectal cancer cells response to apoptotic stimuli
by: Atakpa, Isaac
Published: (2024)

Calreticulin mediates an invasive breast cancer phenotype through the transcriptional dysregulation of p53 and MAPK pathways
by: Zamanian, Mohammadreza, et al.
Published: (2016)

Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors.
by: Shafee, Norazizah, et al.
Published: (2008)

Tumour suppressive effects of WEE1 gene silencing in breast cancer cells.
by: Ghiasi, Naghmeh, et al.
Published: (2013)

The interplay between p53 and p21 tumor suppressor proteins in the transformation of colorectal adenoma to carcinoma.
by: Abdulamir, Ahmed Sahib, et al.
Published: (2008)

Elephantopus scaber induces cytotoxicity in MCF-7 human breast cancer cells via p53-induced apoptosis.
by: Ho, Wan Yong, et al.
Published: (2011)

In vitro anticancer potentials of ethyl p-methoxycinnamate (EPMC) an active ingredient of cekur (Kaempferia galanga) on human oral cancer cell lines differing in p53 status.
by: Ichwan, Solachuddin J. A., et al.
Published: (2018)

Immunohistochemical study of p53 expression in premalignant and malignant cervical neoplasms
by: Tan GC,, et al.
Published: (2007)

An investigation of p53’s differential activation of cell cycle arrest and apoptosis
by: Zhang, Yuan
Published: (2008)

A preliminary study of p53 oncogene expression in lung samples
by: Rahman, Md.Tahminur
Published: (2003)

Is a TNF alpha polymorphism responsible for mutations in the TP53 gene?
by: Berglund, Mattias, et al.
Published: (2011)

Artonin E induces p53-independent g1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cell
by: Etti, Imaobong Christopher, et al.
Published: (2017)

let-7g-5p suppresses the proliferation and expansion of hepatic stellate cells in liver fibrosis via targeting FGF5
by: Zhou, Jiaming, et al.
Published: (2025)

Involvement of the P53 pathway and P161NK4A in the pathogenesis of b-cell lymphomas
by: Zainuddin, Norafiza
Published: (2011)