Efficacy evaluation of combination vaccine of recombinant C-terminal fragments of ApxIA, ApxIIA and ApxIIIA in piglets
The efficacy of the combination vaccine of the individual C-terminal fragments of ApxIA, ApxIIA and ApxIIIA of Actinobacillus pleuropneumoniae (APP) was evaluated in piglets. Twenty piglets were divided equally into 2 groups (n=10). All piglets were intramuscularly primed at 4 week-of-age (0 week po...
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2017
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| Online Access: | http://journalarticle.ukm.my/10673/ http://journalarticle.ukm.my/10673/1/05%20Ja%20Yong%20Moon.pdf |
| _version_ | 1848812466502369280 |
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| author | Moon, Ja Yong Moon Kang, Ji Young Seo, Jeong-Woo Kim, Won Kyong Choi, Yeong Hwan Choi, Min Soo Hur, Jin |
| author_facet | Moon, Ja Yong Moon Kang, Ji Young Seo, Jeong-Woo Kim, Won Kyong Choi, Yeong Hwan Choi, Min Soo Hur, Jin |
| author_sort | Moon, Ja Yong Moon |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | The efficacy of the combination vaccine of the individual C-terminal fragments of ApxIA, ApxIIA and ApxIIIA of Actinobacillus pleuropneumoniae (APP) was evaluated in piglets. Twenty piglets were divided equally into 2 groups (n=10). All piglets were intramuscularly primed at 4 week-of-age (0 week post prime inoculation (WPPI)) and were intramuscularly boosted at 6 week-of-age (2 WPPI). Group A piglets were inoculated with sterile PBS and group B piglets were inoculated with the combination vaccine. Concentrations of each of the C-terminal fragment-specific IgG as determined by ELISA were significantly higher in group B than in group A from 2 WPPI until the end of this study. Clinical signs were observed from only 10% of group B piglets after the challenge with the mixture of APP serotypes 1, 2 and 5 at 4 WPPI, while 50% of group A piglets were protected against APP infections. Overall, intramuscular inoculation with the vaccine candidate can efficiently protect piglets against APP infection. |
| first_indexed | 2025-11-15T00:02:45Z |
| format | Article |
| id | oai:generic.eprints.org:10673 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:02:45Z |
| publishDate | 2017 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:106732017-09-20T09:30:01Z http://journalarticle.ukm.my/10673/ Efficacy evaluation of combination vaccine of recombinant C-terminal fragments of ApxIA, ApxIIA and ApxIIIA in piglets Moon, Ja Yong Moon Kang, Ji Young Seo, Jeong-Woo Kim, Won Kyong Choi, Yeong Hwan Choi, Min Soo Hur, Jin The efficacy of the combination vaccine of the individual C-terminal fragments of ApxIA, ApxIIA and ApxIIIA of Actinobacillus pleuropneumoniae (APP) was evaluated in piglets. Twenty piglets were divided equally into 2 groups (n=10). All piglets were intramuscularly primed at 4 week-of-age (0 week post prime inoculation (WPPI)) and were intramuscularly boosted at 6 week-of-age (2 WPPI). Group A piglets were inoculated with sterile PBS and group B piglets were inoculated with the combination vaccine. Concentrations of each of the C-terminal fragment-specific IgG as determined by ELISA were significantly higher in group B than in group A from 2 WPPI until the end of this study. Clinical signs were observed from only 10% of group B piglets after the challenge with the mixture of APP serotypes 1, 2 and 5 at 4 WPPI, while 50% of group A piglets were protected against APP infections. Overall, intramuscular inoculation with the vaccine candidate can efficiently protect piglets against APP infection. Penerbit Universiti Kebangsaan Malaysia 2017-02 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/10673/1/05%20Ja%20Yong%20Moon.pdf Moon, Ja Yong Moon and Kang, Ji Young and Seo, Jeong-Woo and Kim, Won Kyong and Choi, Yeong Hwan and Choi, Min Soo and Hur, Jin (2017) Efficacy evaluation of combination vaccine of recombinant C-terminal fragments of ApxIA, ApxIIA and ApxIIIA in piglets. Sains Malaysiana, 46 (2). pp. 217-221. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol46num2_2017/contentsVol46num2_2017.html |
| spellingShingle | Moon, Ja Yong Moon Kang, Ji Young Seo, Jeong-Woo Kim, Won Kyong Choi, Yeong Hwan Choi, Min Soo Hur, Jin Efficacy evaluation of combination vaccine of recombinant C-terminal fragments of ApxIA, ApxIIA and ApxIIIA in piglets |
| title | Efficacy evaluation of combination vaccine of recombinant C-terminal fragments of ApxIA, ApxIIA and ApxIIIA in piglets |
| title_full | Efficacy evaluation of combination vaccine of recombinant C-terminal fragments of ApxIA, ApxIIA and ApxIIIA in piglets |
| title_fullStr | Efficacy evaluation of combination vaccine of recombinant C-terminal fragments of ApxIA, ApxIIA and ApxIIIA in piglets |
| title_full_unstemmed | Efficacy evaluation of combination vaccine of recombinant C-terminal fragments of ApxIA, ApxIIA and ApxIIIA in piglets |
| title_short | Efficacy evaluation of combination vaccine of recombinant C-terminal fragments of ApxIA, ApxIIA and ApxIIIA in piglets |
| title_sort | efficacy evaluation of combination vaccine of recombinant c-terminal fragments of apxia, apxiia and apxiiia in piglets |
| url | http://journalarticle.ukm.my/10673/ http://journalarticle.ukm.my/10673/ http://journalarticle.ukm.my/10673/1/05%20Ja%20Yong%20Moon.pdf |