Memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities
The continued progression of neurodegeneration may result in dementia. The present study compared the neuroprotective activities between soybean and tempeh extracts in rats. The extracts were administered orally at 10, 20 and 40 mg/kg for 15 days. Radial arm maze and elevated plus maze served as ext...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2016
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| Online Access: | http://journalarticle.ukm.my/10271/ http://journalarticle.ukm.my/10271/1/02%20Alia%20Hamad.pdf |
| _version_ | 1848812331946999808 |
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| author | Alia Hamad, Vasudevan Mani, Kalavathy Ramasamy, Lim, Siong Meng Abu Bakar Abdul Majeed, |
| author_facet | Alia Hamad, Vasudevan Mani, Kalavathy Ramasamy, Lim, Siong Meng Abu Bakar Abdul Majeed, |
| author_sort | Alia Hamad, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | The continued progression of neurodegeneration may result in dementia. The present study compared the neuroprotective activities between soybean and tempeh extracts in rats. The extracts were administered orally at 10, 20 and 40 mg/kg for 15 days. Radial arm maze and elevated plus maze served as exteroceptive behavioural models for memory measuring. Brain cholinergic activities (acetylcholine and acetylcholinesterase) and neuroinflammatory related cytokines interleukin 1β and interleukin-10 were also tested. Soybean and tempeh extracts significantly improved memory, but overall 40 mg/kg tempeh showed better improvement (p<0.05). The tempeh extracts at 20 and 40 mg/kg exhibited a significant (p<0.05) increase and decrease in the level of acetylcholine and acetylcholinesterase activities, respectively. Tempeh extract (40 mg/kg) resulted in greater reduction (p<0.05) of inflammation than soybean extract. Altogether, tempeh extract may be beneficial in the management and prevention of dementia and Alzheimer’s disease. |
| first_indexed | 2025-11-15T00:00:36Z |
| format | Article |
| id | oai:generic.eprints.org:10271 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:00:36Z |
| publishDate | 2016 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:102712017-04-06T06:43:35Z http://journalarticle.ukm.my/10271/ Memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities Alia Hamad, Vasudevan Mani, Kalavathy Ramasamy, Lim, Siong Meng Abu Bakar Abdul Majeed, The continued progression of neurodegeneration may result in dementia. The present study compared the neuroprotective activities between soybean and tempeh extracts in rats. The extracts were administered orally at 10, 20 and 40 mg/kg for 15 days. Radial arm maze and elevated plus maze served as exteroceptive behavioural models for memory measuring. Brain cholinergic activities (acetylcholine and acetylcholinesterase) and neuroinflammatory related cytokines interleukin 1β and interleukin-10 were also tested. Soybean and tempeh extracts significantly improved memory, but overall 40 mg/kg tempeh showed better improvement (p<0.05). The tempeh extracts at 20 and 40 mg/kg exhibited a significant (p<0.05) increase and decrease in the level of acetylcholine and acetylcholinesterase activities, respectively. Tempeh extract (40 mg/kg) resulted in greater reduction (p<0.05) of inflammation than soybean extract. Altogether, tempeh extract may be beneficial in the management and prevention of dementia and Alzheimer’s disease. Penerbit Universiti Kebangsaan Malaysia 2016-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/10271/1/02%20Alia%20Hamad.pdf Alia Hamad, and Vasudevan Mani, and Kalavathy Ramasamy, and Lim, Siong Meng and Abu Bakar Abdul Majeed, (2016) Memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities. Sains Malaysiana, 45 (9). pp. 1299-1310. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol45num9_2016/contentsVol45num9_2016.htm |
| spellingShingle | Alia Hamad, Vasudevan Mani, Kalavathy Ramasamy, Lim, Siong Meng Abu Bakar Abdul Majeed, Memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities |
| title | Memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities |
| title_full | Memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities |
| title_fullStr | Memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities |
| title_full_unstemmed | Memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities |
| title_short | Memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities |
| title_sort | memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities |
| url | http://journalarticle.ukm.my/10271/ http://journalarticle.ukm.my/10271/ http://journalarticle.ukm.my/10271/1/02%20Alia%20Hamad.pdf |