Stability of membrane bound reactions
We present a novel approach to the dynamics of reactions of diffusing chemical species with species fixed in space e.g. by binding to a membrane. The non-diffusing reaction partners are clustered in areas with a diameter smaller than the diffusion length of the diffusing partner. The activated fraction o...
| Main Authors: | , |
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| Format: | Article |
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American Physical Society
2004
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| Online Access: | https://eprints.nottingham.ac.uk/998/ |
| _version_ | 1848790523332001792 |
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| author | Thul, Ruediger Falcke, Martin |
| author_facet | Thul, Ruediger Falcke, Martin |
| author_sort | Thul, Ruediger |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | We present a novel approach to the dynamics of reactions of diffusing chemical species with species fixed in space e.g. by binding to a membrane. The non-diffusing reaction partners are clustered in areas with a diameter smaller than the diffusion length of the diffusing partner. The activated fraction of the fixed species determines the size of an active sub-region of the cluster. Linear stability analysis reveals that diffusion is one of the ma jor determinants of the stability of the dynamics. We illustrate the model concept with Ca²⁺ dynamics in living cells, which has release channels as fixed reaction partners. Our results suggest that spatial and temporal structures in intracellular Ca²⁺ dynamics are caused by fluctuations due to the small number of channels per cluster. |
| first_indexed | 2025-11-14T18:13:58Z |
| format | Article |
| id | nottingham-998 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:13:58Z |
| publishDate | 2004 |
| publisher | American Physical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-9982020-05-04T20:31:42Z https://eprints.nottingham.ac.uk/998/ Stability of membrane bound reactions Thul, Ruediger Falcke, Martin We present a novel approach to the dynamics of reactions of diffusing chemical species with species fixed in space e.g. by binding to a membrane. The non-diffusing reaction partners are clustered in areas with a diameter smaller than the diffusion length of the diffusing partner. The activated fraction of the fixed species determines the size of an active sub-region of the cluster. Linear stability analysis reveals that diffusion is one of the ma jor determinants of the stability of the dynamics. We illustrate the model concept with Ca²⁺ dynamics in living cells, which has release channels as fixed reaction partners. Our results suggest that spatial and temporal structures in intracellular Ca²⁺ dynamics are caused by fluctuations due to the small number of channels per cluster. American Physical Society 2004 Article PeerReviewed Thul, Ruediger and Falcke, Martin (2004) Stability of membrane bound reactions. Physical Review Letters, 93 (18). p. 188103. ISSN 0031-9007 http://prola.aps.org/pdf/PRL/v93/i18/e188103 10.1103/ PhysRevLet t.93.188103 10.1103/ PhysRevLet t.93.188103 |
| spellingShingle | Thul, Ruediger Falcke, Martin Stability of membrane bound reactions |
| title | Stability of membrane bound reactions |
| title_full | Stability of membrane bound reactions |
| title_fullStr | Stability of membrane bound reactions |
| title_full_unstemmed | Stability of membrane bound reactions |
| title_short | Stability of membrane bound reactions |
| title_sort | stability of membrane bound reactions |
| url | https://eprints.nottingham.ac.uk/998/ https://eprints.nottingham.ac.uk/998/ https://eprints.nottingham.ac.uk/998/ |