Frequency of elemental events of intracellular Ca²⁺ dynamics
The dynamics of intracellular Ca²⁺ is driven by random events called Ca²⁺ puffs, in which Ca²⁺ is liberated from intracellular stores. We show that the emergence of Ca²⁺ puffs can be mapped to an escape process. The mean first passage times that correspond to the stochastic fraction of puff periods are...
| Main Authors: | , |
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| Format: | Article |
| Published: |
American Physical Society
2006
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| Online Access: | https://eprints.nottingham.ac.uk/974/ |
| _version_ | 1848790517465219072 |
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| author | Thul, Ruediger Falcke, Martin |
| author_facet | Thul, Ruediger Falcke, Martin |
| author_sort | Thul, Ruediger |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The dynamics of intracellular Ca²⁺ is driven by random events called Ca²⁺ puffs, in which Ca²⁺ is liberated from intracellular stores. We show that the emergence of Ca²⁺ puffs can be mapped to an escape process. The mean first passage times that correspond to the stochastic fraction of puff periods are computed from a novel master equation and two Fokker-Planck equations. Our results demonstrate that the mathematical modeling of Ca²⁺ puffs has to account for the discrete character of the Ca²⁺ release sites and does not permit a continuous description of the number of
open channels. |
| first_indexed | 2025-11-14T18:13:52Z |
| format | Article |
| id | nottingham-974 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:13:52Z |
| publishDate | 2006 |
| publisher | American Physical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-9742020-05-04T16:26:28Z https://eprints.nottingham.ac.uk/974/ Frequency of elemental events of intracellular Ca²⁺ dynamics Thul, Ruediger Falcke, Martin The dynamics of intracellular Ca²⁺ is driven by random events called Ca²⁺ puffs, in which Ca²⁺ is liberated from intracellular stores. We show that the emergence of Ca²⁺ puffs can be mapped to an escape process. The mean first passage times that correspond to the stochastic fraction of puff periods are computed from a novel master equation and two Fokker-Planck equations. Our results demonstrate that the mathematical modeling of Ca²⁺ puffs has to account for the discrete character of the Ca²⁺ release sites and does not permit a continuous description of the number of open channels. American Physical Society 2006-06-29 Article PeerReviewed Thul, Ruediger and Falcke, Martin (2006) Frequency of elemental events of intracellular Ca²⁺ dynamics. Physical Review E, 73 . 061923/1-061923/14. ISSN 1539-3755 http://journals.aps.org/pre/abstract/10.1103/PhysRevE.73.061923 doi:10.1103/PhysRevE.73.061923 doi:10.1103/PhysRevE.73.061923 |
| spellingShingle | Thul, Ruediger Falcke, Martin Frequency of elemental events of intracellular Ca²⁺ dynamics |
| title | Frequency of elemental events of intracellular Ca²⁺ dynamics |
| title_full | Frequency of elemental events of intracellular Ca²⁺ dynamics |
| title_fullStr | Frequency of elemental events of intracellular Ca²⁺ dynamics |
| title_full_unstemmed | Frequency of elemental events of intracellular Ca²⁺ dynamics |
| title_short | Frequency of elemental events of intracellular Ca²⁺ dynamics |
| title_sort | frequency of elemental events of intracellular ca²⁺ dynamics |
| url | https://eprints.nottingham.ac.uk/974/ https://eprints.nottingham.ac.uk/974/ https://eprints.nottingham.ac.uk/974/ |