The relationship between baseline blood pressure and computed tomography findings in acute stroke: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST)

Background and Purpose—High blood pressure (BP) is present in 80% of patients with acute ischemic stroke and is independently associated with poor outcome. There are few data examining the relationship between admission BP and acute CT findings. Methods—TAIST was a randomized controlled trial ass...

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Main Authors:	Sare, Gillian M., Bath, Philip M.W., Gray, Laura J., Moulin, Thierry, Woimant, France, England, Timothy, Geeganage, Chamila, Christensen, Hanne, De Deyn, Peter Paul, Leys, Didier, O'Neill, Desmond, Ringelstein, Bernd
Format:	Article
Published:	American Heart Association 2009
Online Access:	https://eprints.nottingham.ac.uk/962/

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author	Sare, Gillian M. Bath, Philip M.W. Gray, Laura J. Moulin, Thierry Woimant, France England, Timothy Geeganage, Chamila Christensen, Hanne De Deyn, Peter Paul Leys, Didier O'Neill, Desmond Ringelstein, Bernd
author_facet	Sare, Gillian M. Bath, Philip M.W. Gray, Laura J. Moulin, Thierry Woimant, France England, Timothy Geeganage, Chamila Christensen, Hanne De Deyn, Peter Paul Leys, Didier O'Neill, Desmond Ringelstein, Bernd
author_sort	Sare, Gillian M.
building	Nottingham Research Data Repository
collection	Online Access
description	Background and Purpose—High blood pressure (BP) is present in 80% of patients with acute ischemic stroke and is independently associated with poor outcome. There are few data examining the relationship between admission BP and acute CT findings. Methods—TAIST was a randomized controlled trial assessing 10 days of treatment with tinzaparin versus aspirin in 1489 patients with acute ischemic stroke (48 hr) with admission BP of 220/120 mm Hg. CT brain scans were performed before randomization and after 10 days. The relationships between baseline BP and adjudicated CT findings were assessed. Odds ratios per 10 mm Hg change in BP were calculated. Results—Higher systolic BP (SBP) was associated with abnormal CT scans because of independent associations with chronic changes of leukoariosis (OR, 1.12; 95% CI, 1.05–1.17) and old infarction (OR, 1.12; 95% CI, 1.06 –1.17) at baseline, and signs of visible infarction at day 10 (OR, 1.06; 95% CI, 1.00 –1.13). A lower SBP was associated with signs of acute infarction (OR, 0.94; 95% CI, 0.89–0.99). Hemorrhagic transformation, dense middle cerebral artery sign, mass effect, and cerebral edema at day 10 were not independently associated with baseline BP. Conclusion—Although high baseline BP is independently associated with a poor outcome after stroke, this was not shown to be through an association with increased hemorrhagic transformation, cerebral edema, or mass effect; trial design may be suboptimal to detect this. Higher SBP is associated with visible infarction on day 10 scans. The influence of changing BP in acute stroke on CT findings is still to be ascertained.
first_indexed	2025-11-14T18:13:47Z
format	Article
id	nottingham-962
institution	University of Nottingham Malaysia Campus
institution_category	Local University
last_indexed	2025-11-14T18:13:47Z
publishDate	2009
publisher	American Heart Association
recordtype	eprints
repository_type	Digital Repository
spelling	nottingham-9622020-05-04T20:26:30Z https://eprints.nottingham.ac.uk/962/ The relationship between baseline blood pressure and computed tomography findings in acute stroke: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST) Sare, Gillian M. Bath, Philip M.W. Gray, Laura J. Moulin, Thierry Woimant, France England, Timothy Geeganage, Chamila Christensen, Hanne De Deyn, Peter Paul Leys, Didier O'Neill, Desmond Ringelstein, Bernd Background and Purpose—High blood pressure (BP) is present in 80% of patients with acute ischemic stroke and is independently associated with poor outcome. There are few data examining the relationship between admission BP and acute CT findings. Methods—TAIST was a randomized controlled trial assessing 10 days of treatment with tinzaparin versus aspirin in 1489 patients with acute ischemic stroke (48 hr) with admission BP of 220/120 mm Hg. CT brain scans were performed before randomization and after 10 days. The relationships between baseline BP and adjudicated CT findings were assessed. Odds ratios per 10 mm Hg change in BP were calculated. Results—Higher systolic BP (SBP) was associated with abnormal CT scans because of independent associations with chronic changes of leukoariosis (OR, 1.12; 95% CI, 1.05–1.17) and old infarction (OR, 1.12; 95% CI, 1.06 –1.17) at baseline, and signs of visible infarction at day 10 (OR, 1.06; 95% CI, 1.00 –1.13). A lower SBP was associated with signs of acute infarction (OR, 0.94; 95% CI, 0.89–0.99). Hemorrhagic transformation, dense middle cerebral artery sign, mass effect, and cerebral edema at day 10 were not independently associated with baseline BP. Conclusion—Although high baseline BP is independently associated with a poor outcome after stroke, this was not shown to be through an association with increased hemorrhagic transformation, cerebral edema, or mass effect; trial design may be suboptimal to detect this. Higher SBP is associated with visible infarction on day 10 scans. The influence of changing BP in acute stroke on CT findings is still to be ascertained. American Heart Association 2009-01 Article PeerReviewed Sare, Gillian M., Bath, Philip M.W., Gray, Laura J., Moulin, Thierry, Woimant, France, England, Timothy, Geeganage, Chamila, Christensen, Hanne, De Deyn, Peter Paul, Leys, Didier, O'Neill, Desmond and Ringelstein, Bernd (2009) The relationship between baseline blood pressure and computed tomography findings in acute stroke: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST). Stroke, 40 (1). pp. 41-46. ISSN 0039-2499 http://stroke.ahajournals.org/cgi/reprint/40/1/41?cookietest=yes 10.1161/STROKEAHA.108.526665 10.1161/STROKEAHA.108.526665 10.1161/STROKEAHA.108.526665
spellingShingle	Sare, Gillian M. Bath, Philip M.W. Gray, Laura J. Moulin, Thierry Woimant, France England, Timothy Geeganage, Chamila Christensen, Hanne De Deyn, Peter Paul Leys, Didier O'Neill, Desmond Ringelstein, Bernd The relationship between baseline blood pressure and computed tomography findings in acute stroke: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST)
title	The relationship between baseline blood pressure and computed tomography findings in acute stroke: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST)
title_full	The relationship between baseline blood pressure and computed tomography findings in acute stroke: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST)
title_fullStr	The relationship between baseline blood pressure and computed tomography findings in acute stroke: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST)
title_full_unstemmed	The relationship between baseline blood pressure and computed tomography findings in acute stroke: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST)
title_short	The relationship between baseline blood pressure and computed tomography findings in acute stroke: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST)
title_sort	relationship between baseline blood pressure and computed tomography findings in acute stroke: data from the tinzaparin in acute ischaemic stroke trial (taist)
url	https://eprints.nottingham.ac.uk/962/ https://eprints.nottingham.ac.uk/962/ https://eprints.nottingham.ac.uk/962/

The relationship between baseline blood pressure and computed tomography findings in acute stroke: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST)

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