Telmisartan to prevent recurrent stroke and cardiovascular events
Background Prolonged lowering of blood pressure after a stroke reduces the risk of recurrent stroke. In addition, inhibition of the renin–angiotensin system in high-risk patients reduces the rate of subsequent cardiovascular events, including stroke. However, the effect of lowering of blood pres...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
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Massacheutts Medical Society
2008
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| Online Access: | https://eprints.nottingham.ac.uk/952/ |
| _version_ | 1848790510123089920 |
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| author | Yusuf, Salim Diener, Hans-Christoph Sacco, Ralph L. Cotton, Daniel Ounpuu, Stephanie Lawton, William A. Palesch, Yuko Martin, Renée H. Albers, Gregory W. Bath, Philip M.W. Bornstein, Natan Chan, Bernard P.L. Chen, Sien-Tsong Cunha, Luis Dahlöf, Björn De Keyser, Jacques Donnan, Geoffrey A. Estol, Conrado Gorelick, Philip Gu, Vivian Hermansson, Karin Hillbrich, Lutz Kaste, Markku Lu, Chuanzhen Machnig, Thomas Pais, Prem Roberts, Robin Skvortsova, Veronika Teal, Philip Toni, Danilo Vandermaelen, Cam Voight, Thor Weber, Michael Yoon, Byung-Woo |
| author_facet | Yusuf, Salim Diener, Hans-Christoph Sacco, Ralph L. Cotton, Daniel Ounpuu, Stephanie Lawton, William A. Palesch, Yuko Martin, Renée H. Albers, Gregory W. Bath, Philip M.W. Bornstein, Natan Chan, Bernard P.L. Chen, Sien-Tsong Cunha, Luis Dahlöf, Björn De Keyser, Jacques Donnan, Geoffrey A. Estol, Conrado Gorelick, Philip Gu, Vivian Hermansson, Karin Hillbrich, Lutz Kaste, Markku Lu, Chuanzhen Machnig, Thomas Pais, Prem Roberts, Robin Skvortsova, Veronika Teal, Philip Toni, Danilo Vandermaelen, Cam Voight, Thor Weber, Michael Yoon, Byung-Woo |
| author_sort | Yusuf, Salim |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background
Prolonged lowering of blood pressure after a stroke reduces the risk of recurrent
stroke. In addition, inhibition of the renin–angiotensin system in high-risk patients
reduces the rate of subsequent cardiovascular events, including stroke. However, the
effect of lowering of blood pressure with a renin–angiotensin system inhibitor soon
after a stroke has not been clearly established. We evaluated the effects of therapy
with an angiotensin-receptor blocker, telmisartan, initiated early after a stroke.
Methods
In a multicenter trial involving 20,332 patients who recently had an ischemic stroke,
we randomly assigned 10,146 to receive telmisartan (80 mg daily) and 10,186 to receive
placebo. The primary outcome was recurrent stroke. Secondary outcomes were
major cardiovascular events (death from cardiovascular causes, recurrent stroke,
myocardial infarction, or new or worsening heart failure) and new-onset diabetes.
Results
The median interval from stroke to randomization was 15 days. During a mean followup
of 2.5 years, the mean blood pressure was 3.8/2.0 mm Hg lower in the telmisartan
group than in the placebo group. A total of 880 patients (8.7%) in the telmisartan group
and 934 patients (9.2%) in the placebo group had a subsequent stroke (hazard ratio in
the telmisartan group, 0.95; 95% confidence interval [CI], 0.86 to 1.04; P = 0.23). Major
cardiovascular events occurred in 1367 patients (13.5%) in the telmisartan group and
1463 patients (14.4%) in the placebo group (hazard ratio, 0.94; 95% CI, 0.87 to 1.01;
P = 0.11). New-onset diabetes occurred in 1.7% of the telmisartan group and 2.1% of the
placebo group (hazard ratio, 0.82; 95% CI, 0.65 to 1.04; P = 0.10).
Conclusions
Therapy with telmisartan initiated soon after an ischemic stroke and continued for
2.5 years did not significantly lower the rate of recurrent stroke, major cardiovascular
events, or diabetes. (ClinicalTrials.gov number, NCT00153062.) |
| first_indexed | 2025-11-14T18:13:45Z |
| format | Article |
| id | nottingham-952 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:13:45Z |
| publishDate | 2008 |
| publisher | Massacheutts Medical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-9522020-05-04T16:27:49Z https://eprints.nottingham.ac.uk/952/ Telmisartan to prevent recurrent stroke and cardiovascular events Yusuf, Salim Diener, Hans-Christoph Sacco, Ralph L. Cotton, Daniel Ounpuu, Stephanie Lawton, William A. Palesch, Yuko Martin, Renée H. Albers, Gregory W. Bath, Philip M.W. Bornstein, Natan Chan, Bernard P.L. Chen, Sien-Tsong Cunha, Luis Dahlöf, Björn De Keyser, Jacques Donnan, Geoffrey A. Estol, Conrado Gorelick, Philip Gu, Vivian Hermansson, Karin Hillbrich, Lutz Kaste, Markku Lu, Chuanzhen Machnig, Thomas Pais, Prem Roberts, Robin Skvortsova, Veronika Teal, Philip Toni, Danilo Vandermaelen, Cam Voight, Thor Weber, Michael Yoon, Byung-Woo Background Prolonged lowering of blood pressure after a stroke reduces the risk of recurrent stroke. In addition, inhibition of the renin–angiotensin system in high-risk patients reduces the rate of subsequent cardiovascular events, including stroke. However, the effect of lowering of blood pressure with a renin–angiotensin system inhibitor soon after a stroke has not been clearly established. We evaluated the effects of therapy with an angiotensin-receptor blocker, telmisartan, initiated early after a stroke. Methods In a multicenter trial involving 20,332 patients who recently had an ischemic stroke, we randomly assigned 10,146 to receive telmisartan (80 mg daily) and 10,186 to receive placebo. The primary outcome was recurrent stroke. Secondary outcomes were major cardiovascular events (death from cardiovascular causes, recurrent stroke, myocardial infarction, or new or worsening heart failure) and new-onset diabetes. Results The median interval from stroke to randomization was 15 days. During a mean followup of 2.5 years, the mean blood pressure was 3.8/2.0 mm Hg lower in the telmisartan group than in the placebo group. A total of 880 patients (8.7%) in the telmisartan group and 934 patients (9.2%) in the placebo group had a subsequent stroke (hazard ratio in the telmisartan group, 0.95; 95% confidence interval [CI], 0.86 to 1.04; P = 0.23). Major cardiovascular events occurred in 1367 patients (13.5%) in the telmisartan group and 1463 patients (14.4%) in the placebo group (hazard ratio, 0.94; 95% CI, 0.87 to 1.01; P = 0.11). New-onset diabetes occurred in 1.7% of the telmisartan group and 2.1% of the placebo group (hazard ratio, 0.82; 95% CI, 0.65 to 1.04; P = 0.10). Conclusions Therapy with telmisartan initiated soon after an ischemic stroke and continued for 2.5 years did not significantly lower the rate of recurrent stroke, major cardiovascular events, or diabetes. (ClinicalTrials.gov number, NCT00153062.) Massacheutts Medical Society 2008-08-27 Article PeerReviewed Yusuf, Salim, Diener, Hans-Christoph, Sacco, Ralph L., Cotton, Daniel, Ounpuu, Stephanie, Lawton, William A., Palesch, Yuko, Martin, Renée H., Albers, Gregory W., Bath, Philip M.W., Bornstein, Natan, Chan, Bernard P.L., Chen, Sien-Tsong, Cunha, Luis, Dahlöf, Björn, De Keyser, Jacques, Donnan, Geoffrey A., Estol, Conrado, Gorelick, Philip, Gu, Vivian, Hermansson, Karin, Hillbrich, Lutz, Kaste, Markku, Lu, Chuanzhen, Machnig, Thomas, Pais, Prem, Roberts, Robin, Skvortsova, Veronika, Teal, Philip, Toni, Danilo, Vandermaelen, Cam, Voight, Thor, Weber, Michael and Yoon, Byung-Woo (2008) Telmisartan to prevent recurrent stroke and cardiovascular events. New England Journal of Medicine, 359 (12). pp. 1225-1237. ISSN 0028-4793 http://content.nejm.org/cgi/content/full/359/12/1225 10.1056/NEJMoa0804593 10.1056/NEJMoa0804593 10.1056/NEJMoa0804593 |
| spellingShingle | Yusuf, Salim Diener, Hans-Christoph Sacco, Ralph L. Cotton, Daniel Ounpuu, Stephanie Lawton, William A. Palesch, Yuko Martin, Renée H. Albers, Gregory W. Bath, Philip M.W. Bornstein, Natan Chan, Bernard P.L. Chen, Sien-Tsong Cunha, Luis Dahlöf, Björn De Keyser, Jacques Donnan, Geoffrey A. Estol, Conrado Gorelick, Philip Gu, Vivian Hermansson, Karin Hillbrich, Lutz Kaste, Markku Lu, Chuanzhen Machnig, Thomas Pais, Prem Roberts, Robin Skvortsova, Veronika Teal, Philip Toni, Danilo Vandermaelen, Cam Voight, Thor Weber, Michael Yoon, Byung-Woo Telmisartan to prevent recurrent stroke and cardiovascular events |
| title | Telmisartan to prevent recurrent stroke and cardiovascular events |
| title_full | Telmisartan to prevent recurrent stroke and cardiovascular events |
| title_fullStr | Telmisartan to prevent recurrent stroke and cardiovascular events |
| title_full_unstemmed | Telmisartan to prevent recurrent stroke and cardiovascular events |
| title_short | Telmisartan to prevent recurrent stroke and cardiovascular events |
| title_sort | telmisartan to prevent recurrent stroke and cardiovascular events |
| url | https://eprints.nottingham.ac.uk/952/ https://eprints.nottingham.ac.uk/952/ https://eprints.nottingham.ac.uk/952/ |