DNA charge neutralisation by linear polymers II: reversible binding
We model the way in which polymers bind to DNA and neutralise its charged backbone by analysing the dynamics of the distribution of gaps along the DNA. We generalise existing theory for irreversible binding to construct new deterministic models which include polymer removal, movement along the...
| Main Authors: | , , |
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| Format: | Article |
| Published: |
2006
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| Online Access: | https://eprints.nottingham.ac.uk/936/ |
| _version_ | 1848790506539057152 |
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| author | Maltsev, Eugene Wattis, Jonathan A.D. Byrne, Helen M. |
| author_facet | Maltsev, Eugene Wattis, Jonathan A.D. Byrne, Helen M. |
| author_sort | Maltsev, Eugene |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | We model the way in which polymers bind to DNA and neutralise
its charged backbone by analysing the dynamics of the distribution
of gaps along the DNA.
We generalise existing theory for irreversible binding to construct
new deterministic models which include polymer removal,
movement along the DNA and allow for binding with overlaps.
We show that reversible binding alters the capacity of the DNA
for polymers by allowing the rearrangement of polymer positions
over a longer timescale than when binding is irreversible.
When the polymers do not overlap, allowing reversible binding
increases the number of polymers adhered and hence the charge that
the DNA can accommodate; in contrast, when overlaps occur, reversible
binding reduces the amount of charge neutralised by the polymers. |
| first_indexed | 2025-11-14T18:13:42Z |
| format | Article |
| id | nottingham-936 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:13:42Z |
| publishDate | 2006 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-9362020-05-04T20:30:07Z https://eprints.nottingham.ac.uk/936/ DNA charge neutralisation by linear polymers II: reversible binding Maltsev, Eugene Wattis, Jonathan A.D. Byrne, Helen M. We model the way in which polymers bind to DNA and neutralise its charged backbone by analysing the dynamics of the distribution of gaps along the DNA. We generalise existing theory for irreversible binding to construct new deterministic models which include polymer removal, movement along the DNA and allow for binding with overlaps. We show that reversible binding alters the capacity of the DNA for polymers by allowing the rearrangement of polymer positions over a longer timescale than when binding is irreversible. When the polymers do not overlap, allowing reversible binding increases the number of polymers adhered and hence the charge that the DNA can accommodate; in contrast, when overlaps occur, reversible binding reduces the amount of charge neutralised by the polymers. 2006 Article PeerReviewed Maltsev, Eugene, Wattis, Jonathan A.D. and Byrne, Helen M. (2006) DNA charge neutralisation by linear polymers II: reversible binding. Physical Review E, 74 . 041918. ISSN 1539-3755 http://pre.aps.org/browse |
| spellingShingle | Maltsev, Eugene Wattis, Jonathan A.D. Byrne, Helen M. DNA charge neutralisation by linear polymers II: reversible binding |
| title | DNA charge neutralisation by linear polymers II:
reversible binding |
| title_full | DNA charge neutralisation by linear polymers II:
reversible binding |
| title_fullStr | DNA charge neutralisation by linear polymers II:
reversible binding |
| title_full_unstemmed | DNA charge neutralisation by linear polymers II:
reversible binding |
| title_short | DNA charge neutralisation by linear polymers II:
reversible binding |
| title_sort | dna charge neutralisation by linear polymers ii:
reversible binding |
| url | https://eprints.nottingham.ac.uk/936/ https://eprints.nottingham.ac.uk/936/ |