Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis
Gating of sensory information can be assessed using an auditory conditioning-test paradigm which measures the reduction in the auditory evoked response to a test stimulus following an initial conditioning stimulus. Recording brainwaves from specific areas of the brain using multiple electrodes is h...
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| Format: | Article |
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Springer Verlag
2008
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| Online Access: | https://eprints.nottingham.ac.uk/877/ |
| _version_ | 1848790495894962176 |
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| author | Zachariou, Margarita Dissanayake, Dilshani W N Coombes, Stephen Owen, Markus R. Mason, Robert |
| author_facet | Zachariou, Margarita Dissanayake, Dilshani W N Coombes, Stephen Owen, Markus R. Mason, Robert |
| author_sort | Zachariou, Margarita |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Gating of sensory information can be assessed using an auditory conditioning-test paradigm which measures the reduction in the auditory evoked response to a test stimulus following an initial conditioning stimulus. Recording brainwaves from specific areas of the brain using multiple electrodes is helpful in the study of the neurobiology of sensory gating. In this paper, we use such technology to investigate the role of cannabinoids in sensory gating in the CA3 region of the rat hippocampus. Our experimental results show that application of the exogenous cannabinoid agonist WIN55,212-2 can abolish sensory gating. We have developed a phenomenological model of cannabinoid dynamics incorporated within a spiking neural network model of CA3 with synaptically interacting pyramidal and basket cells. Direct numerical simulations of this model suggest that
the basic mechanism for this effect can be traced to the suppression of inhibition of slow GABAB synapses. Furthermore, by working with a simpler mathematical firing rate model we are able to show the robustness of this mechanism for the abolition of sensory gating. |
| first_indexed | 2025-11-14T18:13:32Z |
| format | Article |
| id | nottingham-877 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:13:32Z |
| publishDate | 2008 |
| publisher | Springer Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-8772020-05-04T16:27:28Z https://eprints.nottingham.ac.uk/877/ Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis Zachariou, Margarita Dissanayake, Dilshani W N Coombes, Stephen Owen, Markus R. Mason, Robert Gating of sensory information can be assessed using an auditory conditioning-test paradigm which measures the reduction in the auditory evoked response to a test stimulus following an initial conditioning stimulus. Recording brainwaves from specific areas of the brain using multiple electrodes is helpful in the study of the neurobiology of sensory gating. In this paper, we use such technology to investigate the role of cannabinoids in sensory gating in the CA3 region of the rat hippocampus. Our experimental results show that application of the exogenous cannabinoid agonist WIN55,212-2 can abolish sensory gating. We have developed a phenomenological model of cannabinoid dynamics incorporated within a spiking neural network model of CA3 with synaptically interacting pyramidal and basket cells. Direct numerical simulations of this model suggest that the basic mechanism for this effect can be traced to the suppression of inhibition of slow GABAB synapses. Furthermore, by working with a simpler mathematical firing rate model we are able to show the robustness of this mechanism for the abolition of sensory gating. Springer Verlag 2008-04-23 Article PeerReviewed Zachariou, Margarita, Dissanayake, Dilshani W N, Coombes, Stephen, Owen, Markus R. and Mason, Robert (2008) Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis. Cognitive Neurodynamics, 2 . pp. 159-170. ISSN 1871-4099 sensory gating cannabinoids GABAB firing rate models https://link.springer.com/article/10.1007%2Fs11571-008-9050-4 doi:10.1007/s11571-008-9050-4 doi:10.1007/s11571-008-9050-4 |
| spellingShingle | sensory gating cannabinoids GABAB firing rate models Zachariou, Margarita Dissanayake, Dilshani W N Coombes, Stephen Owen, Markus R. Mason, Robert Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis |
| title | Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis |
| title_full | Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis |
| title_fullStr | Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis |
| title_full_unstemmed | Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis |
| title_short | Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis |
| title_sort | sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis |
| topic | sensory gating cannabinoids GABAB firing rate models |
| url | https://eprints.nottingham.ac.uk/877/ https://eprints.nottingham.ac.uk/877/ https://eprints.nottingham.ac.uk/877/ |