How epidemiology has challenged 3 prevailing concepts about atopic dermatitis
We challenge 3 prevailing concepts in understanding atopic dermatitis using data from epidemiologic studies. First, we show that although atopy is associated with atopic dermatitis to some degree, its importance is not likely to be a simple causeand- effect relationship, especially at a populati...
| Main Authors: | , |
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| Format: | Article |
| Published: |
Elsevier
2006
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| Online Access: | https://eprints.nottingham.ac.uk/861/ |
| _version_ | 1848790492989358080 |
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| author | Williams, Hywel Flohr, Carsten |
| author_facet | Williams, Hywel Flohr, Carsten |
| author_sort | Williams, Hywel |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | We challenge 3 prevailing concepts in understanding atopic
dermatitis using data from epidemiologic studies. First, we
show that although atopy is associated with atopic dermatitis to
some degree, its importance is not likely to be a simple causeand-
effect relationship, especially at a population level. Our
epidemiologic data do not exclude a contributory role for IgEmediated
immunologic processes, especially in those with
existing and severe disease. Second, evidence is presented that
does not support a straightforward inverse relationship
between infections and atopic dermatitis risk. A link, if present,
is likely to be more complex, depending critically on the timing
and type of infectious exposure. Third, recent evidence suggests
that the risk of subsequent childhood asthma is not increased in
children with early atopic dermatitis who are not also early
wheezers, suggesting a comanifestation of phenotypes rather
than a progressive atopic march. Collectively, these
observations underline the importance of epidemiologic studies
conducted at a population level to gain a more balanced
understanding of the enigma of atopic dermatitis. |
| first_indexed | 2025-11-14T18:13:29Z |
| format | Article |
| id | nottingham-861 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:13:29Z |
| publishDate | 2006 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-8612020-05-04T20:30:26Z https://eprints.nottingham.ac.uk/861/ How epidemiology has challenged 3 prevailing concepts about atopic dermatitis Williams, Hywel Flohr, Carsten We challenge 3 prevailing concepts in understanding atopic dermatitis using data from epidemiologic studies. First, we show that although atopy is associated with atopic dermatitis to some degree, its importance is not likely to be a simple causeand- effect relationship, especially at a population level. Our epidemiologic data do not exclude a contributory role for IgEmediated immunologic processes, especially in those with existing and severe disease. Second, evidence is presented that does not support a straightforward inverse relationship between infections and atopic dermatitis risk. A link, if present, is likely to be more complex, depending critically on the timing and type of infectious exposure. Third, recent evidence suggests that the risk of subsequent childhood asthma is not increased in children with early atopic dermatitis who are not also early wheezers, suggesting a comanifestation of phenotypes rather than a progressive atopic march. Collectively, these observations underline the importance of epidemiologic studies conducted at a population level to gain a more balanced understanding of the enigma of atopic dermatitis. Elsevier 2006 Article PeerReviewed Williams, Hywel and Flohr, Carsten (2006) How epidemiology has challenged 3 prevailing concepts about atopic dermatitis. Journal of Allergy and Clinical Immunology, 118 . pp. 209-213. ISSN 0091-6749 |
| spellingShingle | Williams, Hywel Flohr, Carsten How epidemiology has challenged 3 prevailing concepts about atopic dermatitis |
| title | How epidemiology has challenged 3 prevailing
concepts about atopic dermatitis |
| title_full | How epidemiology has challenged 3 prevailing
concepts about atopic dermatitis |
| title_fullStr | How epidemiology has challenged 3 prevailing
concepts about atopic dermatitis |
| title_full_unstemmed | How epidemiology has challenged 3 prevailing
concepts about atopic dermatitis |
| title_short | How epidemiology has challenged 3 prevailing
concepts about atopic dermatitis |
| title_sort | how epidemiology has challenged 3 prevailing
concepts about atopic dermatitis |
| url | https://eprints.nottingham.ac.uk/861/ |