The molecular basis of atypicality in antipsychotic drug action

QR Code

The molecular basis of atypicality in antipsychotic drug action

Dopamine D2 receptor (D2R) antagonism is thought to be the pharmacological mechanism behind the clinical efficacy of antipsychotic drugs (APDs) in treating the positive symptoms of schizophrenia. Unfortunately, D2R antagonism is also associated with extrapyramidal symptoms (EPS) that encompass a ran...

Full description

Bibliographic Details
Main Author:	Lockington, Hannah J.
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2025
Subjects:	Antipsychotic drugs Dopamine D2 Receptor Drug rebinding Pharmacological chaperones
Online Access:	https://eprints.nottingham.ac.uk/80591/

Similar Items

D-amphetamine and antipsychotic drug effects on latent inhibition in mice lacking dopamine D2 receptors
by: Bay-Richter, C., et al.
Published: (2013)

DRD2/ANKK1 Taq1A (rs 1800497 C>T) genotypes are associated with susceptibility to second generation antipsychotic-induced akathisia
by: Lawford, B., et al.
Published: (2013)

Determination of agonist intrinsic efficacies at the dopamine D2 receptor
by: Stott, Lisa Alice
Published: (2017)

Effects of D- and L-govadine on the disruption of touchscreen object-location paired associates learning in rats by acute MK-801 treatment
by: Lins, Brittney, et al.
Published: (2015)

Medicinal Chemistry & Chemical Biology Approaches to Investigate Prospective Treatments for CNS Diseases: Dopamine D1 Receptor Positive Allosteric Modulators, Dopamine D2 Receptor Positive & Negative Allosteric Modulators, Dopamine D2 Receptor-Ligand Kinetics
by: Fyfe, Tim
Published: (2019)

Dissociable effects of the d- and l- enantiomers of govadine on the disruption of prepulse inhibition by MK-801 and apomorphine in male Long-Evans rats
by: Lins, Brittney, et al.
Published: (2017)

Antipsychotic prescribing to patients diagnosed with dementia without a diagnosis of psychosis in the context of national guidance and drug safety warnings: longitudinal study in UK general practice
by: Stocks, S. Jill, et al.
Published: (2017)

Role of D1 receptor antagonism in contextual fear learning and memory
by: Heath, Florence
Published: (2015)

Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors
by: Sykes, David A., et al.
Published: (2017)

A role for rebinding in the prevalence of on-target side effects of clinically used antipsychotics
by: Sykes, David A
Published: (2020)

Alcohol Use Disorders Identification Test (AUDIT) scores are elevated in antipsychotic-induced hyperprolactinaemia
by: Lawford, B., et al.
Published: (2012)

Antipsychotic prescribing for vulnerable populations: a clinical audit at an acute Australian mental health unit at two-time points
by: McMillan, Sara S., et al.
Published: (2017)

The role of oxidative stress in antipsychotics induced ovarian toxicity
by: Elmorsy, Ekramy, et al.
Published: (2017)

Effect of antipsychotics on mitochondrial bioenergetics of rat ovarian theca cells
by: Elmorsy, Ekramy, et al.
Published: (2017)

Deciphering the neural mechanisms of oxytocin’s prosocial and antipsychotic-like effects
by: Abrahams, Abigail Bethany
Published: (2021)

Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence
by: Baker, Travis E., et al.
Published: (2018)

Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors
by: van der Westhuizen, Emma T., et al.
Published: (2018)

Bioenergetic disruption of human micro-vascular endothelial cells by antipsychotics
by: Elmorsy, Ekramy, et al.
Published: (2015)

Corticosterone and dopamine D2/D3 receptors mediate the motivation for voluntary wheel running in C57BL/6J mice
by: Ebada, Mohamed Elsaed Elsayed, et al.
Published: (2016)

Potentiation of latent inhibition by haloperidol and clozapine is attenuated in Dopamine D2 receptor (Drd-2) deficient mice: Do antipsychotics influence learning to ignore irrelevant stimuli via both Drd-2 and non-Drd-2 mechanisms?
by: O'Callaghan, M.J., et al.
Published: (2014)

Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood–brain barrier
by: Elmorsy, Ekramy, et al.
Published: (2014)

Intracellular drug delivery: a route to more selective and effective treatments for disease
by: Mai, Quynh N.
Published: (2019)

Analysis of adverse drug reactions related to drug-induced renal injury based on spontaneous adverse drug reactions reporting in Malaysia 2010 – 2014 / Nurulmaya Ahmad Sa'ad
by: Ahmad Sa'ad, Nurulmaya
Published: (2016)

Hollow-Core Magnetic Colloidal Nanocrystal Clusters with Ligand-Exchanged Surface Modification as Delivery Vehicles for Targeted and Stimuli-Responsive Drug Release
by: Li, D., et al.
Published: (2012)

On-Demand Dopamine Receptor Activation via Photoresponsive Nanoparticle-Dopamine Conjugates with an Emphasis on Parkinson’s Disease
by: Alghamdi, Hajar
Published: (2024)

Assessment of pharmacists, public and general retailers perspectives, awareness and knowledge of registered drugs and unregistered drugs in Klang Valley / Nur Wahida Zulkifli
by: Zulkifli, Nur Wahida
Published: (2018)

Silk Road: Ebay for drugs
by: Barratt, Monica
Published: (2012)

Investigating the molecular basis of biased signalling at cannabinoid receptors
by: Dennis, Morgan Jane
Published: (2023)

Factor of drug rejections and stigma toward drug consumers and drugs / Seema Shamira Muhammad Sani Surinder, Abdul Rauf Ridzuan and Rosilawati Sultan Mohideen
by: Muhammad Sani Surinder, Seema Shamira, et al.
Published: (2019)

Learning lessons from adverse drug reactions in children
by: Sammons, Helen, et al.
Published: (2016)

The suppression of illicit drugs through international law
by: Boister, Neil
Published: (1998)

Evaluation of drug related problems in hospitalized acute coronary syndrome patients / Kuapih @ Florina Kimjun
by: Kimjun, Kuapih @ Florina
Published: (2014)

Research on nonsteroidal anti-inflammatory drugs in Malaysia: a bibliometric analysis
by: Zin, Che Suraya, et al.
Published: (2020)

Design, Synthesis, and Evaluation of New P2Y2 Receptor Antagonists and Fluorescent Ligands
by: Knight, Rebecca
Published: (2025)

Drug utilization review among geriatric patients at primary care setting / Saidatul Sheeda Ahmad Shukri
by: Ahmad Shukri, Saidatul Sheeda
Published: (2015)

Synergistic effects of Gefitinib and Paclitaxel in breast cancer treatment using cockle shell-derived nanoparticle
by: Chemmalar, Sangaran
Published: (2023)

An observational feasibility study of a new anaesthesia drug storage tray
by: Almghairbi, Dalal S., et al.
Published: (2018)

Effects of microwave on drug release profiles of guluronic acid-rich alginate spheroids / Nurul Hidayah Mohd Salleh
by: Mohd Salleh, Nurul Hidayah
Published: (2015)

A grounded study of the experience of detoxification from psychoactive drugs.
by: Bartu, Anne
Published: (1998)

An appraisal of the laws for the treatment and rehabilitation of drug dependants in Malaysia / Zafani Zainudin, Rozianti Mohamed Hanaphi and Tariq Azfar Maketab
by: Zainudin, Zafani, et al.
Published: (2007)