Experimental design for discrepant models: selecting mechanistic models of IKr through informative experiments

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Experimental design for discrepant models: selecting mechanistic models of IKr through informative experiments

In cardiac electrophysiology applications, mathematical models are relied upon to provide quantitatively accurate predictions. The potassium current IKr is of particular importance because its blockage by drugs is known to cause dangerous changes in heart rhythm. To help quantify the risk presented...

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Bibliographic Details
Main Author:	Shuttleworth, Joseph George
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2025
Subjects:	medicine mathematical modelling biomathemmatics electrophysiology
Online Access:	https://eprints.nottingham.ac.uk/80409/

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