Identification of genes and pathways regulated by the PRH/HHEX transcription factor in endothelial and lymphatic cells

QR Code

Identification of genes and pathways regulated by the PRH/HHEX transcription factor in endothelial and lymphatic cells

The Proline-Rich Homeodomain protein (PRH/HHEX) is recognized as an essential transcription factor in development and in the adult. PRH regulates transcription by binding directly to DNA at specific regions of target genes, often containing specific DNA sequence motifs to which it has a high affinit...

Full description

Bibliographic Details
Main Author:	Dahhan, Rania
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2024
Subjects:	Transcription factors; Vascular homeostasis; Endothelial cells; Angiogenic tube formation; Cell proliferation; Vascular biology; Angiogenesis; Lymphangiogenesis
Online Access:	https://eprints.nottingham.ac.uk/79962/

Similar Items

Effects of omentin on endothelial disruption and hydrogen peroxide-induced inflammation in vascular endothelial cell monolayer
by: Kamaruddin, Nur Aqilah
Published: (2022)

Altered ratios of pro- and anti-angiogenic VEGF-A variants and pericyte expression of DLL4 disrupt the vascular maturation in infantile haemangioma
by: Ye, Xi, et al.
Published: (2016)

Exploring the potential role of endothelial ZEB1 in developmental and pathological angiogenesis
by: Green, Kathryn
Published: (2025)

Cellular and molecular mechanisms underlying extravasation of human Wharton’s jelly mesenchymal stem cells across fetal and adult endothelial cell monolayers
by: Ebrahim, Neven
Published: (2016)

Pre-eclampsia: the role of vascular endothelial growth factor and its interaction with the vascular endothelium
by: Brockelsby, Jeremy Charles
Published: (2001)

Understanding the ZEB1 interactome during lymphangiogenesis
by: Ahmed, Nada
Published: (2025)

Mechanisms of interferon-gamma (IFN-y)-induced hyperpermeability changes in human umbilical vein endothelial cells
by: Ng, Chin Theng
Published: (2017)

The role of Proline-Rich Homeodomain protein PRH/HHEX in cholangiocarcinoma
by: Ghouth, Nahlah
Published: (2024)

Control of collateral formation as a therapeutic for cardiovascular disease
by: Amartey, Jason
Published: (2024)

In vitro anti-atherogenic effects of asiatic acid in human aortic endothelial cells
by: Fong, Lai Yen
Published: (2016)

The effect of quorum sensing molecules on vascular function
by: Alassaf, Fawaz A.
Published: (2018)

Dynamics of cytokine induced E-selectin expression in endothelial cells
by: Ogrodzinski, Lydia
Published: (2023)

SUMOylation as a regulatory mechanism for the Sox3 transcription factor
by: Alfassam, Haifa
Published: (2019)

Properties of asiaticoside in suppressing hyperpermeability in human umbilical vein endothelial cells induced by interferon-gamma
by: Khairudin, Nurnabila Huda
Published: (2016)

In vitro protective effects of 2,4,6-trihydroxy-3-geranyl acetophenone on junctional protein disruption and the underlying signaling pathways in lipopolysaccharide-induced endothelial hyperpermeability
by: Chan, Yee Han
Published: (2022)

Identification of long non-coding RNAs in serum exosomes from colorectal cancer patients and effects of exosomes on tube formation by endothelial cells
by: Ng, Chin Tat
Published: (2019)

VEGF-A165b protects against proteinuria in a mouse model with progressive depletion of all endogenous VEGF-A splice isoforms from the kidney
by: Stevens, Megan, et al.
Published: (2017)

Investigating the role of ZEB1 in Lymphangiogenesis
by: Tabrizi, Zarah Beth
Published: (2024)

The effect of gestational diabetes on human umbilical mesenchymal stem cells and their ability to influence endothelial permeability
by: Salem, Samar
Published: (2023)

Molecular pharmacology of VEGF-A isoforms: binding and signalling at VEGFR2
by: Peach, Chloe, et al.
Published: (2018)

Pattern Formation by Lateral Inhibition in Physiological and Tumour Angiogenesis
by: Smith, Holly
Published: (2020)

SUMOylation of Sox2 in neural stem cells
by: Marelli, Elisa
Published: (2018)

Expression profiling of genes related to endothelial cell function in pre-diabetes and type 2 diabetes subjects
by: Moradipoor, Sara
Published: (2016)

The role of Gfi1s/1b transcription factors in the molecular programming of vertebrate erythropoiesis
by: Alnassay, Farah
Published: (2024)

Factors influencing luteal angiogenesis and alternative splicing in the bovine ovary
by: Thompson, Robert F.
Published: (2018)

Gene therapy using plasmid DNA encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports
by: Kovac, Milomir, et al.
Published: (2017)

The cardiovascular and functional consequences of arteriovenous fistula formation in chronic kidney disease
by: Korsheed, Shvan
Published: (2011)

Peripheral contributions to the development and maintenance of inflammation and pain in arthritis
by: Amanitis, Dimitrios
Published: (2022)

Effects of 2,4,6-trihydroxy-3-geranyl acetophenone on growth factor-induced human bronchial smooth muscle cell proliferation in asthma
by: Yap, Hui Min
Published: (2018)

The relationship between in-vitro endothelial permeability and molecules of the intercellular junction
by: Budworth, Rachel Ann
Published: (2003)

The Effect of Carbon Disulfide on Oxidative Injury in Vein Endothelial Cells
by: Chen, S., et al.
Published: (2006)

Identification of novel factors contributing to the regulation of PIN-FORMED 7 (PIN7) transcription, in the Arabidopsis root
by: Goodall, Benjamin
Published: (2018)

Elucidating the role of hyperglycaemia in endothelial cell and pericyte morphology, function and crosstalk, and blood-brain barrier integrity
by: Hashmat, Arshad
Published: (2024)

Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF)
by: Barratt, Shaney L., et al.
Published: (2018)

Macrophage-derived interleukin-1beta promotes human breast cancer cell migration and lymphatic adhesion in vitro
by: Storr, Sarah J., et al.
Published: (2017)

Molecular modelling of platelet endothelial cell adhesion molecule 1 and its interaction with glycosaminoglycans
by: Gandhi, Neha Sureshchandra
Published: (2007)

Cytotoxic Effect of Betulinic Acid on Vascular Smooth Muscle Cells
by: Vadivelu, Raja Kumar
Published: (2009)

Biphasic effects of autophagy on decompression bubble-induced endothelial injury
by: Wang, M., et al.
Published: (2019)

Objective assessment of blood and lymphatic vessel invasion and association with macrophage infiltration in cutaneous melanoma
by: Storr, Sarah J., et al.
Published: (2011)

Investigating the effects of drug combinations and loss of the PRH/Hhex oncoprotein in CCA cells
by: Martin, Grace
Published: (2025)