Design and Evaluation of a Human Microglia Model: Drug Delivery and the Inhibitory Impact of PPARβ Agonist on Inflammation

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Design and Evaluation of a Human Microglia Model: Drug Delivery and the Inhibitory Impact of PPARβ Agonist on Inflammation

Neuroinflammation is a hallmark of various neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Microglia and astrocytes, the primary immune cells of the central nervous system (CNS), play a crucial role in the initiation and progression...

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Bibliographic Details
Main Author:	Aloufi, Rawan
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2024
Subjects:	neuroinflammation Peroxisome proliferator-activated receptors (PPARs) fatty acid-binding proteins (FABPs) microglia astrocytes neurodegenerative diseases PPARβ GW0742 monocyte-derived microglia RNA sequencing SUMOylation NF-κB signaling pro-inflammatory cytokines neuroprotection
Online Access:	https://eprints.nottingham.ac.uk/79469/

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