The transcriptional regulation of VEGF production from pulmonary artery smooth muscle cells by TGFβ1

QR Code

The transcriptional regulation of VEGF production from pulmonary artery smooth muscle cells by TGFβ1

Pulmonary Hypertension (PH) is a rare and fatal disease of the pulmonary vasculature. Hyperplasia and hypertrophy of smooth muscle cells in muscular arteries and arrival of smooth muscle cell in non-muscular pulmonary arteries are key pathological features of PH. VEGF has a strong role in embryon...

Full description

Bibliographic Details
Main Author:	Clifford, Rachel
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2009
Subjects:	pulmonary hypertension tgf beta vegf transcriptional regulation smooth muscle signalling receptors
Online Access:	https://eprints.nottingham.ac.uk/78841/

Similar Items

Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis
by: Calver, J.F.
Published: (2023)

Suberanilohydroxamic acid prevents TGF-β1-induced COX-2 repression in human lung fibroblasts post-transcriptionally by TIA-1 downregulation
by: Pasini, Alice, et al.
Published: (2018)

Investigating a role for heterotrimeric G-proteins in activating TGFβ in asthma
by: Middlewick, Robert James
Published: (2020)

The impact of elevated pulmonary artery pressure on exercise responses
by: Fowler, Robin
Published: (2012)

Cytotoxic Effect of Betulinic Acid on Vascular Smooth Muscle Cells
by: Vadivelu, Raja Kumar
Published: (2009)

Mechanisms of transforming growth factor-β activation in airway smooth muscle cells and its role in asthma
by: Tatler, Amanda Louise
Published: (2010)

The role of histone arginine methylation in cytokine/chemokine gene expression in airway smooth muscle cells in asthma
by: Kaczmarek, Klaudia
Published: (2019)

Effect of cigarette smoke extract and hypoxia on vasoactive gene expression and mediator release in human pulmonary artery smooth muscle and endothelial cells
by: Alqarni, Abdullah Abdulghani M.
Published: (2020)

Aberrant DNA methylation and its regulation of gene expression in airway smooth muscle cells of individuals with asthma
by: Clifford, Rachel Louise
Published: (2023)

The amino-terminal domain of the androgen receptor co-opts extracellular signal-regulated kinase (ERK) docking sites in ELK1 protein to induce sustained gene activation that supports prostate cancer cell growth
by: Rosati, Rayna, et al.
Published: (2016)

Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development
by: Metzler, Veronika M., et al.
Published: (2017)

Design, synthesis and pharmacological evaluation of efficacy selective β2 adrenoceptor agonists
by: Lumb, Elliott
Published: (2019)

Utility of the precision cut lung slice model to investigate airway smooth muscle contraction
by: Fox, Jane
Published: (2011)

Real-time analysis of the binding of fluorescent VEGF₁₆₅a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes
by: Kilpatrick, Laura E., et al.
Published: (2017)

Role of VEGF-A in chronic pain
by: Hulse, Richard P.
Published: (2017)

Effects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats
by: Carter, Joanne J., et al.
Published: (2016)

The role of mesenchymal G proteins in pulmonary fibrosis and lung development
by: Goodwin, Amanda T.
Published: (2021)

Regulation of human feto-placental endothelial barrier integrity by vascular endothelial growth factors: competitive interplay between VEGF-A165a, VEGF-A165b, PIGF and VE-cadherin
by: Pang, Vincent, et al.
Published: (2017)

Differential regulation of blood flow induced neovascularisation and mural cell recruitment by VEGF and angiopoietin signaling
by: Stone, Oliver A., et al.
Published: (2017)

Association of aromatase with bladder cancer stage and long-term survival: new insights into the hormonal paradigm in bladder cancer
by: Nguyen, Daniel P., et al.
Published: (2017)

Discovering the molecular basis for ligand pharmacological activity on β-adrenoceptors
by: Bunsuz, Asuman
Published: (2023)

The role of galectin-3 in the development of idiopathic pulmonary fibrosis
by: Parmar, Nimesh
Published: (2019)

Real-time ligand binding of fluorescent VEGF-A isoforms that discriminate between VEGFR2 and NRP1 in living cells
by: Peach, Chloe J., et al.
Published: (2018)

A comparison of the acute haemodynamic response to aerobic and resistance exercise in subjects with exercise-induced pulmonary arterial hypertension
by: Fowler, Robin, et al.
Published: (2013)

Matrix metalloproteinase-1 mediated extra-cellular matrix remodelling contributes to airway smooth muscle growth and asthma severity
by: Naveed, Shams-un-nisa
Published: (2018)

Development of a Size Targeted Formulation to Treat Pulmonary Arterial Hypertension
by: Swainson, Sadie M E
Published: (2020)

Non-classical mechanisms of steroid sensing in the ovary: lessons from the bovine oxytocin model
by: Ivell, Richard, et al.
Published: (2014)

Clonally expanded human airway smooth muscle cells exhibit morphological and functional heterogeneity
by: Singh, Shailendra R., et al.
Published: (2014)

Safety aspect of β2-agonists in chronic obstructive pulmonary diesease
by: Whale, Christopher Ian
Published: (2009)

MMP-1 activation contributes to airway smooth muscle growth and asthma severity
by: Naveed, Shams-un-nisa, et al.
Published: (2017)

Effect of cigarette smoke extract on inflammatory cytokine production and corticosteroid insensitivity in human airway smooth muscle cells
by: Alahmari, Mushabbab
Published: (2022)

Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment
by: Hutchings, Catherine J., et al.
Published: (2013)

The study of progesterone action in human myometrial explants
by: Georgiou, E.X., et al.
Published: (2016)

Modulation of mu-opioid receptor dynamics at the plasma membrane and its implications for signalling and trafficking
by: Underwood, Owen George
Published: (2024)

Effects of VEGF-A165b and SRPK1 inhibition on pain behaviour, cyclooxygenase expression and glial activation in the CNS in a model of osteoarthritis
by: Almahasneh, Fatimah
Published: (2018)

Income Smoothing - an Analysis on the Current Evidence of Research
by: Ramli, Sohimi
Published: (1999)

Comorbidities and Medication Burden in Patients with Chronic Obstructive Pulmonary Disease Attending Pulmonary Rehabilitation
by: Noteboom, Ben, et al.
Published: (2014)

Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF)
by: Barratt, Shaney L., et al.
Published: (2018)

Engineering ‘extracellular matrix factories’ to study how the extracellular microenvironment regulates gene expression
by: Tomlin, Hannah
Published: (2021)

Preparation of potent and selective αvβ6 integrin inhibitors for the treatment of idiopathic pulmonary fibrosis and synthetic approaches towards the total synthesis of mescengricin
by: Robinson, Henry Duncan
Published: (2021)