Exploring the effects of ageing, cancer, and exercise on skeletal muscle mitochondrial function

QR Code

Exploring the effects of ageing, cancer, and exercise on skeletal muscle mitochondrial function

As the worldwide population ages, there becomes a growing prevalence of age associated muscle mass and function, known as sarcopenia. Sarcopenia is well recognised to be associated with poor health outcomes, with reduced life expectancy and worse clinical outcomes well established. The ageing popula...

Full description

Bibliographic Details
Main Author:	Smart, Thomas
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2024
Subjects:	Sarcopenia; Cancer cachexia; Skeletal muscle; Mitochondrial oxidative phosphorylation; Aging; Effect of exercise
Online Access:	https://eprints.nottingham.ac.uk/78817/

Similar Items

Exploring the role of mitochondria in the changes seen in overall skeletal muscle health associated with ageing and cancer
by: Hatt, Jacob
Published: (2021)

Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice
by: McMahon, C., et al.
Published: (2014)

Molecular analyses provide insight into mechanisms underlying sarcopenia and myofibre denervation in old skeletal muscles of mice
by: Barns, M., et al.
Published: (2014)

The impact of leucine-enriched whey protein on skeletal muscle anabolism
by: Ely, Isabel
Published: (2024)

Therapeutic exercise in cancer cachexia: exploring approaches and outcomes
by: Maddocks, Matthew
Published: (2010)

Development and application of novel stable isotopic approaches to study human skeletal muscle in response to exercise and ageing
by: Brook, Matthew
Published: (2017)

Understanding the role of mitochondrial haemoglobin - an in silico approach
by: Katyal, Gunjan
Published: (2022)

Development and application of minimally invasive stable isotope tracers’ measures of muscle mass and muscle protein synthesis/breakdown: insights into ageing skeletal muscle
by: Cegielski, Jessica
Published: (2020)

Investigating a novel exercise training strategy on neuromuscular health
by: Ely, Isabel A
Published: (2020)

The heterogeneity of the functional, metabolic, and molecular responses of skeletal muscle and clinical adaptations to exercise training in pre-clinical and human models
by: Farrash, Wesam
Published: (2020)

Mouse mitochondrial lipid composition is defined by age in brain and muscle
by: Pollard, Amelia K., et al.
Published: (2017)

The role of the pyruvate dehydrogenase complex in the regulation of human skeletal muscle fuel metabolism
by: Laithwaite, David
Published: (2009)

Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men
by: Tsintzas, Kostas, et al.
Published: (2017)

Investigation of muscle mass and metabolic regulation in human volunteers: the impact of resistance exercise, pharmacological intervention and obesity
by: Taylor, Tariq Yaqub
Published: (2020)

The age-related loss of skeletal muscle mass and function: measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans
by: Wilkinson, Daniel J., et al.
Published: (2018)

Effects of ageing and vitamin D deficiency on vitamin D receptor (VDR) expression in human skeletal muscle
by: Ong, Terence
Published: (2015)

The roles of muscle contraction and pharmaceuticals on restoring glucose uptake in a mouse skeletal muscle model of immobilization
by: Kirkpatrick, Euan
Published: (2024)

Resistance-exercise training: the effects on muscle function, body composition and risk factors for chronic disease with ageing
by: Phillips, Bethan E.
Published: (2012)

Human muscle weakness and fatigue: the effects of disuse, age and exercise
by: White, Michael J.
Published: (1987)

The effects of age upon the expression of three miRNAs in muscle stem cells isolated from two different porcine skeletal muscles
by: Redshaw, Zoe, et al.
Published: (2014)

LY2495655, an antimyostatin antibody in pancreatic cancer: a randomized phase 2 trial
by: Golan, Talia, et al.
Published: (2018)

Mitochondrial proteomic profiling reveals increased carbonic anhydrase II in aging and neurodegeneration
by: Pollard, Amelia, et al.
Published: (2016)

Metabolic and functional characterisation of adult skeletal muscle in down syndrome mouse model (Ts1CJe) for insights into hypotonia in human condition
by: Lim, Chai Ling
Published: (2017)

Modulation of muscle protein metabolism through amino acid supplementation and exercise in older women
by: Bukhari, Syed Shabbar Ijaz
Published: (2020)

Enriching a protein drink with leucine augments muscle protein synthesis after resistance exercise in young and older men
by: Atherton, Philip J., et al.
Published: (2016)

Study investigating the role of skeletal muscle mass estimation in metastatic spinal cord compression
by: Gakhar, H., et al.
Published: (2015)

Mitochondrial haemoglobin and ATP synthase – molecular interactions in health and disease
by: Ebanks, Brad
Published: (2023)

A novel puromycin decorporation method to quantify skeletal muscle protein breakdown: a proof-of-concept study
by: Crossland, Hannah, et al.
Published: (2017)

The effect of vitamin D on the development and function of skeletal muscle
by: Alliband, Kathryn
Published: (2024)

Endocrine and immune responses to resistance training in prostate cancer patients
by: Galvao, D, et al.
Published: (2008)

Acute disuse muscle atrophy in health and disease: an investigation of the timecourse, functional effects and a potential treatment strategy
by: Hardy, Edward John Oliver
Published: (2023)

The metabolic and molecular mechanisms of hyperammonaemia and hyperethanolaemia induced protein catabolism in skeletal muscle cells
by: Crossland, Hannah, et al.
Published: (2018)

The role of skeletal muscle in the initiation and progression of knee osteoarthritis
by: Tonge, Daniel Paul
Published: (2010)

Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation
by: Stephens, Francis B., et al.
Published: (2014)

Differential nitric oxide levels in the blood and skeletal muscle of Type 2 diabetic subjects may be consequence of adiposity: a preliminary study.
by: Krause, M., et al.
Published: (2012)

Human skeletal muscle disuse atrophy: effects on muscle protein synthesis, breakdown and insulin resistance- a qualitative review
by: Rudrappa, Supreeth S., et al.
Published: (2016)

Nutrient modulation in the management of disease-induced muscle wasting: evidence from human studies
by: Brook, Matthew S., et al.
Published: (2017)

Mitochondrial DNA haplogroups and ageing mechanisms in osteoarthritis
by: Valdes, Ana M., et al.
Published: (2017)

Skeletal muscle remodeling in response to eccentric vs. concentric loading: morphological, molecular, and metabolic adaptations
by: Franchi, Martino V., et al.
Published: (2017)

Understanding neuromuscular responses to pharmacological and exercise interventions: Manipulating motor unit plasticity in humans to improve muscle function
by: Jones, Eleanor J.
Published: (2024)