Chemical and in silico exploration of novel 5-hydroxytryptamine 2A receptor (5-HT2AR) ligands

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Chemical and in silico exploration of novel 5-hydroxytryptamine 2A receptor (5-HT2AR) ligands

The 5-HT2AR is a target in neuropsychiatric conditions such as psychosis, which is commonly managed with atypical antipsychotics. These have associated side effects due to off-target interactions. Consequently, there is a demand to develop therapeutics that exhibit no affinity for these off-target s...

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Bibliographic Details
Main Author:	Damerum, Luke
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2024
Subjects:	5-HT2A serotonin 2A receptor GPCR structure based drug design membrane proteins
Online Access:	https://eprints.nottingham.ac.uk/78719/

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