Sugar-coated nanoparticles: Investigating lipid-terminated glycopolymers for targeted nanoparticle delivery of nucleic acids
RNA-based therapeutics are set to transform disease treatment, having already revolutionised our approach to vaccination. However, RNA therapeutics are rapidly degraded by blood enzymes upon administration, do not readily enter cells to their site of action, and do not specifically enter the cell ty...
| Main Author: | Fiedler, Benjamin |
|---|---|
| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2024
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/78178/ |
Similar Items
Characterisation and Intercellular Mechanistic Analysis of Supramolecular, Cationic, mRNA-Loaded Polyplexes for Efficient Transfection in HEK293T and A549 Cells
by: Smith, Silvia
Published: (2023)
by: Smith, Silvia
Published: (2023)
Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA
by: Capel, Victoria, et al.
Published: (2018)
by: Capel, Victoria, et al.
Published: (2018)
Insight into the relationship between the cell culture model, cell trafficking and siRNA silencing efficiency
by: Capel, Victoria, et al.
Published: (2016)
by: Capel, Victoria, et al.
Published: (2016)
Part A: RNA Therapeutics. Development and challenges in nanoparticle delivery/ Part B: Synthesis and characterisation of supramolecular polyplexes for mRNA delivery
by: Vasudevan, Akshaya
Published: (2024)
by: Vasudevan, Akshaya
Published: (2024)
Treatment of lung cancer using nanoparticle drug delivery systems
by: Chandolu, V., et al.
Published: (2013)
by: Chandolu, V., et al.
Published: (2013)
(E)-Vinylphosphonates: nuclease-stable phosphate mimics for effective single-stranded RNA gene silencing
by: Al-Kadhimi, Mustafa M.
Published: (2020)
by: Al-Kadhimi, Mustafa M.
Published: (2020)
Development of a targeted drug delivery system for the treatment of hepatitis C virus infection
by: Baloch, Baby Kanwal
Published: (2012)
by: Baloch, Baby Kanwal
Published: (2012)
Molecular biology approaches to quantify subcellular localisation of mRNA therapeutics
by: Smart, Alfredo D.
Published: (2025)
by: Smart, Alfredo D.
Published: (2025)
Study on Liposomes Integrity and Delivery of siRNA to Lung Cancer
by: Aljasser, Abdullah
Published: (2024)
by: Aljasser, Abdullah
Published: (2024)
Development and application of a linear polyamidoamine-SiRNA delivery system
by: Fathi, Zainab H
Published: (2018)
by: Fathi, Zainab H
Published: (2018)
Synthesis and Advanced Characterisation of Nanoparticle Gene Delivery Systems for mRNA therapeutics
by: Khosravi, Rahman
Published: (2025)
by: Khosravi, Rahman
Published: (2025)
In-vitro investigations into endocytosis and silencing of siRNA-liposomes
by: ALSHEHRI, ABDULLAH ALI D
Published: (2017)
by: ALSHEHRI, ABDULLAH ALI D
Published: (2017)
Characterization of miR-3099-mediated posttranscriptional of target genes regulation during neurogenesis in mice
by: Zainal Abidin, Shahidee
Published: (2019)
by: Zainal Abidin, Shahidee
Published: (2019)
Mixed anionic and cationic polyphosphazene complexes for effective gene delivery to glioblastoma in vitro and in vivo
by: Hsu, Wei-Hsin
Published: (2018)
by: Hsu, Wei-Hsin
Published: (2018)
The dynamic role of mRNA m6A methylation in Arabidopsis thaliana and Solanum lycopersicum
by: Chak, Samuel Erwin Seng Chung
Published: (2024)
by: Chak, Samuel Erwin Seng Chung
Published: (2024)
Reconstitution of the Core Ccr4-Not Complex and Evidence for Possible Interaction between YTHDF2 and Human CNOT9
by: Gong, Yutong
Published: (2025)
by: Gong, Yutong
Published: (2025)
Identifying potential RNA editing sites from RNA-Sequencing data from human brain tissue
by: North, Francesca Louise
Published: (2018)
by: North, Francesca Louise
Published: (2018)
An in silico approach to design potential siRNA molecules for ICP22 (US1) gene silencing of different strains of human herpes simplex 1
by: Nur, Suza, et al.
Published: (2013)
by: Nur, Suza, et al.
Published: (2013)
Investigating Current Delivery Vehicles for Efficient and Targeted Delivery of Therapeutic RNA and Future Perspectives
Part A - Investigating current delivery vehicles for efficient and targeted delivery of therapeutic RNA and future perspectives/ Part B - The development of novel polymeric nanoparticles as efficient non-viral RNA delivery vectors
by: Sachan, Isha
Published: (2023)
by: Sachan, Isha
Published: (2023)
Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs
by: Dhir, Ashish, et al.
Published: (2015)
by: Dhir, Ashish, et al.
Published: (2015)
Development of delayed ripening papaya (Carica papaya L.) CV. 'eksotika' using RNA interference and antisense technologies
by: Sekeli, Rogayah
Published: (2013)
by: Sekeli, Rogayah
Published: (2013)
RNA interference therapeutics for cancer: challenges and opportunities
by: Bora, R., et al.
Published: (2012)
by: Bora, R., et al.
Published: (2012)
Investigation of the PABPC1-BTG2 interaction and its effects on mRNA deadenylation by CNOT7(CAF1)
by: Ameerul Moominin, Aalam Mohammed
Published: (2022)
by: Ameerul Moominin, Aalam Mohammed
Published: (2022)
Development of miRNA-mimic nanoparticles for the treatment of brain tumours
by: Anithiya Ramamoorthi Gopalram, Shubaash
Published: (2017)
by: Anithiya Ramamoorthi Gopalram, Shubaash
Published: (2017)
Optimization Of RNA Extraction And Generation Of Expressed Sequence Tags From Sargassum Binderi (Sonder) J. Agardh
by: Wong, Tony Kok Min
Published: (2005)
by: Wong, Tony Kok Min
Published: (2005)
Nucleic acid extraction from biomining microorganisms
by: Zammit, Carla, et al.
Published: (2009)
by: Zammit, Carla, et al.
Published: (2009)
Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: synthesis, structural and functional characterisation
by: Soukarieh, Fadi, et al.
Published: (2016)
by: Soukarieh, Fadi, et al.
Published: (2016)
Identification of factors required for m6A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI
by: Růžička, Kamil, et al.
Published: (2017)
by: Růžička, Kamil, et al.
Published: (2017)
The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module
by: Maryati, Marayti, et al.
Published: (2015)
by: Maryati, Marayti, et al.
Published: (2015)
MicroRNA Regulation in the Inflammatory Response
by: Martin, Athena
Published: (2023)
by: Martin, Athena
Published: (2023)
Development of a stable T7 RNA polymerase expressing cell line using a lentivirus system
by: Yeong, Ming Yue
Published: (2019)
by: Yeong, Ming Yue
Published: (2019)
Exploiting Multicomponent Polymerisations for Non-Viral Gene Delivery
by: O'Shaughnessy, Lewis
Published: (2025)
by: O'Shaughnessy, Lewis
Published: (2025)
Investigating the role of eIF4A2 in the spatial regulation of metabolic adaptation to hypoxia in colorectal cancer
by: Thornton, Luke
Published: (2023)
by: Thornton, Luke
Published: (2023)
Rational engineering of Apoferritin-based nanoparticles for drug delivery
by: Crowhurst, Samuel
Published: (2025)
by: Crowhurst, Samuel
Published: (2025)
Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection
by: Cong, Wei, et al.
Published: (2017)
by: Cong, Wei, et al.
Published: (2017)
Development of in vitro screening approaches to optimise formulation performance.
by: Gallas, Andrzej
Published: (2014)
by: Gallas, Andrzej
Published: (2014)
Alternative RNA splicing: contribution to pain and potential therapeutic strategy
by: Donaldson, Lucy F., et al.
Published: (2016)
by: Donaldson, Lucy F., et al.
Published: (2016)
ATNT: an enhanced system for expression of polycistronic secondary metabolite gene clusters in Aspergillus niger
by: Geib, Elena, et al.
Published: (2017)
by: Geib, Elena, et al.
Published: (2017)
The bacteriophage carrier state of Campylobacter jejuni features changes in host non-coding RNAs and the acquisition of new host-derived CRISPR spacer sequences
by: Hooton, Steven P.T., et al.
Published: (2016)
by: Hooton, Steven P.T., et al.
Published: (2016)
Exploring the biological functions of vtRNA 1-1
by: Wainwright, Thomas
Published: (2023)
by: Wainwright, Thomas
Published: (2023)
Similar Items
-
Characterisation and Intercellular Mechanistic Analysis of Supramolecular, Cationic, mRNA-Loaded Polyplexes for Efficient Transfection in HEK293T and A549 Cells
by: Smith, Silvia
Published: (2023) -
Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA
by: Capel, Victoria, et al.
Published: (2018) -
Insight into the relationship between the cell culture model, cell trafficking and siRNA silencing efficiency
by: Capel, Victoria, et al.
Published: (2016) -
Part A: RNA Therapeutics. Development and challenges in nanoparticle delivery/ Part B: Synthesis and characterisation of supramolecular polyplexes for mRNA delivery
by: Vasudevan, Akshaya
Published: (2024) -
Treatment of lung cancer using nanoparticle drug delivery systems
by: Chandolu, V., et al.
Published: (2013)