New Approaches for Post-Surgical Treatment of Glioblastoma: Targeting GLI-Similar (GLIS) Genes with Stimuli-Responsive Polymer/RNA Complexes

QR Code

New Approaches for Post-Surgical Treatment of Glioblastoma: Targeting GLI-Similar (GLIS) Genes with Stimuli-Responsive Polymer/RNA Complexes

Glioblastoma is the deadliest type of brain tumour, and many therapy approaches have been applied to increase the median life expectancy. However, clinical outcomes have not improved, and innovative glioblastoma treatments are needed. Targeting GLI1-3 and GLI-associated genes (GLIPR1 and GLIS1-3 gen...

Full description

Bibliographic Details
Main Author:	Gumus, Nurcan
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2024
Subjects:	glioblastoma hydrogels genes
Online Access:	https://eprints.nottingham.ac.uk/78098/

Similar Items

MicroRNA analysis of the invasive margin of glioblastoma reveals drugable therapeutic targets in lipid metabolism pathways
by: Alfardus, Huda
Published: (2020)

Development of an EGFR-targeted Drug Delivery System for Glioblastoma
by: Zhao, Zi-Ruo
Published: (2023)

Enhanced dendritic cell immunotherapy to treat glioblastoma
by: Adhikaree, Jason
Published: (2019)

Surgical delivery of drug releasing poly(lactic-co-glycolic acid)/poly(ethylene glycol) paste with in vivo effects against glioblastoma
by: Smith, Stuart J., et al.
Published: (2014)

Surgical delivery of drug releasing poly(lactic-co-glycolic acid)/poly(ethylene glycol) paste with in vivo effects against glioblastoma
by: Smith, Stuart J., et al.
Published: (2014)

Regional profiling of abnormal protein expression & post translational modifications in glioblastoma
by: Kocon, Artur
Published: (2019)

Mixed anionic and cationic polyphosphazene complexes for effective gene delivery to glioblastoma in vitro and in vivo
by: Hsu, Wei-Hsin
Published: (2018)

Chlorotoxin as a Drug Delivery System to treat Glioblastoma
by: Fawzy, Ahmed Faadil
Published: (2021)

Molecular responses of U87-glioblastoma multiform cancer stem cells to HSV-G47Δ oncolytic virus in normoxia and hypoxia tumor microenvironments
by: Reza, Vazifehmand Rodposhtei
Published: (2021)

Investigating the Differential Regulation of Cell Surface GAG in Cancer: Using NGPD to Isolate Cancer Cell Specific Peptides
by: Hardie, Derek T.
Published: (2024)

Identifying the metabolic 'Achilles heel' of adult and paediatric glioblastoma multiforme
by: Wood, James
Published: (2019)

Developing a sprayable drug delivery system for the local delivery of nanoparticles in glioblastoma multiforme
by: McCrorie, Phoebe
Published: (2021)

The role of calcium activated and voltage gated potassium channel BK, in glioblastoma multiforme membrane potential.
by: Ratnasingham, Mathuscha
Published: (2024)

The role of miRNA regulation in response to hypoxia in gliomas
by: Smith, Louise
Published: (2023)

Studying relationship between increased 5-methylcytosine oxidation and expression of cancer stem cell markers in glioblastoma cell lines
by: Wijeyagumar, Vithusha
Published: (2018)

Apoferritin delivery of imidazotetrazine agents for targeted brain tumour therapy
by: Bouzinab, Kaouthar
Published: (2021)

Development of lipid nanocapsules for antiangiogenic treatment of glioblastoma and evaluation of their potential for nose-to-brain drug delivery
by: Pourbaghi Masouleh, Milad
Published: (2019)

Two methods for three - dimensional culture: addition of exogenous ECM components and capture of endogenous ECM components
by: McGinlay, Sarah
Published: (2023)

To F-SIMS/XPS chemical depth profiling of synthetic polymer hydrogels
by: Taylor, Michael
Published: (2017)

Creating new food microstructure: aerated hydro and aerogels
by: Samanci, S.
Published: (2020)

CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma
by: Smith, Stuart J., et al.
Published: (2012)

MicroRNA regulation of glycolytic metabolism in glioblastoma multiforme
by: Alfardus, Huda, et al.
Published: (2017)

Targeted delivery of short hairpin RNA expressing plasmid using hepatitis B virus-like particle for bcl-2 gene silencing in cervical cancer cells
by: Akwiditya, Made Angga
Published: (2021)

Gradient delivery of bioactive molecules across porous hydrogels
by: Eltaher, Hoda M.M.A.
Published: (2016)

Bio-responsive hydrogels for an in vitro brain cancer cell model: self-controlled inhibition of matrix metalloproteinase activity
by: Russo, Emanuele
Published: (2020)

Combining extracellular matrix hydrogels and electrical stimulation to influence macrophage polarisation
by: Whitehead, Charlie D.
Published: (2024)

Nanotherapeutics as a localised drug delivery system for the treatment of GBM
by: Vasey, Catherine E
Published: (2021)

Development of miRNA-mimic nanoparticles for the treatment of brain tumours
by: Anithiya Ramamoorthi Gopalram, Shubaash
Published: (2017)

Targeting DNA repair for personalisation of glioblastoma therapy
by: Perry, Christina Joy
Published: (2016)

CodingQuarry: Highly accurate hidden Markov model gene prediction in fungal genomes using RNA-seq transcripts
by: Testa, Alison, et al.
Published: (2015)

3D Biomimetic matrices to design in vitro stem cell niches
by: Martins Figueiredo, Lara Isabel
Published: (2018)

Synthesis and Biological Evaluation of Novel Imidazotetrazines
by: Summers, Helen S
Published: (2019)

MicroRNA Regulation in the Inflammatory Response
by: Martin, Athena
Published: (2023)

Hyperbranched polymers as non-viral vectors for gene delivery
by: Alazzo, Ali
Published: (2018)

Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation
by: Dixon, James E., et al.
Published: (2014)

User-defined biomimetic scaffolds through "click" modification of self-assembling peptide hydrogels
by: Merrett, Christopher G.
Published: (2024)

The molecular and phenotypic basis of the glioma invasive perivascular niche
by: Diksin, Mohammed, et al.
Published: (2017)

Investigating the roles of long-non-coding RNA genes in zebrafish haematopoiesis
by: Alzaqqah, Fatemah
Published: (2020)

Encapsulation of metal complex into apoferritin for drug delivery and prodrug activation
by: Cassioli, Maria Letizia
Published: (2023)

The impact of oxytocin and GlyT1 inhibitors on social behaviour
by: Kohli, Shivali
Published: (2018)