PHARMACOLOGICAL EVALUATION OF NOVEL COMPOUNDS AS ALZHEIMER’S DISEASE TREATMENT
Background: Alzheimer’s Disease (AD) is an age-related and progressive neurogenerative disorder characterised by a progressive loss of memory and cognitive impairments. Excessive Aβ deposition and tau hyperphosphorylation are pathological characteristics of AD, which are accompanied by oxidative str...
| Main Author: | Li, Tian-Tian |
|---|---|
| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2024
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/78011/ |
Similar Items
In vivo pharmacological evaluation of a novel dual-target inhibitor and methylprednisolone as Alzheimer’s disease treatments
by: Zhang, Bocheng
Published: (2023)
by: Zhang, Bocheng
Published: (2023)
Alternative splicing and the inhibition of splicing kinases in Alzheimer’s Disease
by: Alalwany, Roaa
Published: (2021)
by: Alalwany, Roaa
Published: (2021)
Investigating genetic variation in Alzheimer’s disease
by: Patel, Tulsi
Published: (2018)
by: Patel, Tulsi
Published: (2018)
Multitarget drug design strategy in Alzheimer’s disease: focus on cholinergic transmission and amyloid-β aggregation
by: Simioni, Elena, et al.
Published: (2017)
by: Simioni, Elena, et al.
Published: (2017)
Default mode network perturbations in Alzheimer's disease: an fMRI study in Klang Valley, Malaysia
by: Mohad Azmi, Nur Hafizah, et al.
Published: (2024)
by: Mohad Azmi, Nur Hafizah, et al.
Published: (2024)
Investigating polygenic risk scores in Alzheimer's disease
by: Chaudhury, Sultan Raja
Published: (2024)
by: Chaudhury, Sultan Raja
Published: (2024)
Consumption of fish and Alzheimer's Disease
by: Newton, Wendy, et al.
Published: (2011)
by: Newton, Wendy, et al.
Published: (2011)
Diet and Alzheimer's disease
by: Creegan, R., et al.
Published: (2013)
by: Creegan, R., et al.
Published: (2013)
Rationalising the role of Keratin 9 as a biomarker for Alzheimer’s disease
by: Richens, Joanna L., et al.
Published: (2016)
by: Richens, Joanna L., et al.
Published: (2016)
Development of an allele-specific polymerase chain reaction genotyping test and association of selected single nucleotide polymorphisms and analytes with the risk of alzheimer’s disease / Mohd Nazif Samat @ Darawi
by: Samat @ Darawi, Mohd Nazif
Published: (2014)
by: Samat @ Darawi, Mohd Nazif
Published: (2014)
Evaluation of AChE inhibitors and dual AChE/GSK3-β inhibitor as Alzheimer’s disease treatment
by: Uras, G
Published: (2021)
by: Uras, G
Published: (2021)
Neuroprotective effects of thymoquinone-rich fraction and thymoquinone nanoemulsions in sporadic alzheimer’s disease rat model
by: Ismail, Norsharina
Published: (2019)
by: Ismail, Norsharina
Published: (2019)
Potential of phytochemicals as a treatment for Alzheimer’s disease: evaluation of anticholinesterase activity, antioxidant properties, and cytotoxicity
by: Aljadaan, Adel
Published: (2025)
by: Aljadaan, Adel
Published: (2025)
Prediction of Alzheimer disease using improved MMSE ensemble regressor based on magnetic resonance images
by: Farzan, Ali
Published: (2015)
by: Farzan, Ali
Published: (2015)
Development and structure activity relationship of diarylpentadienone and chalcone analogues as potential anti-inflammatory agent
by: Mohd Faudzi, Siti Munirah
Published: (2015)
by: Mohd Faudzi, Siti Munirah
Published: (2015)
Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities
by: Ka-Heng, Lee, et al.
Published: (2009)
by: Ka-Heng, Lee, et al.
Published: (2009)
Elucidation of the anti-inflammatory compound present in Jatropha curcas Linn Root and its mode of action
by: Othman, Ahmad Razi
Published: (2016)
by: Othman, Ahmad Razi
Published: (2016)
Reproducibility of gait variability measures in people with Alzheimer's disease
by: Wittwer, J., et al.
Published: (2013)
by: Wittwer, J., et al.
Published: (2013)
The effect of memantine and the ladybird alkaloid, harmonine, on NMDA receptor function and Alzheimer’s disease
by: Kaur, Kiran
Published: (2022)
by: Kaur, Kiran
Published: (2022)
Latrepirdine: Molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases
by: Bharadwaj, P., et al.
Published: (2013)
by: Bharadwaj, P., et al.
Published: (2013)
Common polygenic variation can predict risk of Alzheimer’s disease
by: Escott-Price, Valentina, et al.
Published: (2015)
by: Escott-Price, Valentina, et al.
Published: (2015)
Investigation into patterns of epigenetic regulation of Alzheimer’s disease
by: Boden, Kirsty
Published: (2019)
by: Boden, Kirsty
Published: (2019)
Calculating polygenic risk score for individuals with sporadic early onset Alzheimer’s disease
by: Chaudhury, Sultan R
Published: (2017)
by: Chaudhury, Sultan R
Published: (2017)
Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors (part II)
by: Wang, Jia, et al.
Published: (2018)
by: Wang, Jia, et al.
Published: (2018)
Anti-inflammatory activities in Stachytarpheta jamaicensis (L.) vahl ethyl acetate leaf extract
by: Liew, Pearl Majorie
Published: (2017)
by: Liew, Pearl Majorie
Published: (2017)
Anti-inflammatory activity of 5-(3,4-dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one (synthetic curcuminoid analogue) in mice
by: Hisamuddin, Nadia
Published: (2019)
by: Hisamuddin, Nadia
Published: (2019)
Optimizing formation of fatty acid ester nanoemulsion systems for non-steroidal anti-inflammatory drug delivery
by: Mat Hadzir, Nursyamsyila
Published: (2012)
by: Mat Hadzir, Nursyamsyila
Published: (2012)
Design, synthesis, anti-inflammatory activity evaluation, and structure-activities relationship (SAR) study of diarylpentanoid derivatives
by: Leong, Sze Wei
Published: (2014)
by: Leong, Sze Wei
Published: (2014)
Anti-acetylcholinesterase activity and antioxidant properties of extracts and fractions of Carpolobia lutea
by: Nwidu, Lucky Legbosi, et al.
Published: (2017)
by: Nwidu, Lucky Legbosi, et al.
Published: (2017)
Identification of functional variants in the Alzheimer’s disease candidate gene ABCA7
by: Clement, Naomi Susan
Published: (2017)
by: Clement, Naomi Susan
Published: (2017)
FK866 reduces axon pathology in in vitro and in vivo models of Huntington’s disease and Alzheimer’s disease and attenuates behavioral abnormalities
by: Othman, Othman Ahmad
Published: (2016)
by: Othman, Othman Ahmad
Published: (2016)
The effect of Thymosine-ß4 on macrophage phenotype in Alzheimer’s disease
by: Hussain, Ikra
Published: (2019)
by: Hussain, Ikra
Published: (2019)
A longitudinal study of change in falls risk and balance and mobility in healthy older people and people with Alzheimer disease
by: Suttanon, P., et al.
Published: (2013)
by: Suttanon, P., et al.
Published: (2013)
Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Alzheimer’s and Parkinson’s diseases
by: Guerreiro, Rita, et al.
Published: (2016)
by: Guerreiro, Rita, et al.
Published: (2016)
Investigating ApoE4-Mediated Molecular Alterations in H4 Neuroglioma Cells of Alzheimer’s Disease Using OrbiSIMS and LC-MS/MS.
by: Lu, Li
Published: (2025)
by: Lu, Li
Published: (2025)
Anti-acute inflammatory effect of hibiscus rosa-sinensis l. and hibiscus rosa-sinensis var. alba flower and leaf ethanol extracts and its mechanism of action in rats
by: Raduan, Siti Zaleha
Published: (2013)
by: Raduan, Siti Zaleha
Published: (2013)
A state of delirium: deciphering the effect of inflammation on tau pathology in Alzheimer's disease
by: Barron, Matthew, et al.
Published: (2016)
by: Barron, Matthew, et al.
Published: (2016)
Evaluating The effects of lipopolysaccharides and hydrogen peroxide on human and mouse astrocytes in vivo and in vitro, in relation to Alzheimer’s Disease
by: Sivaram, Anjali
Published: (2024)
by: Sivaram, Anjali
Published: (2024)
Anti-inflammatory activity of Haruan (Channa striatus bloch) cream on 12-O-tetradecanoylphorbol-13-acetate-induced chronic dermatitis in mice model
by: Mohamad Isa, Irma Izani
Published: (2015)
by: Mohamad Isa, Irma Izani
Published: (2015)
Mutation analysis of sporadic early-onset Alzheimer's disease using the NeuroX array
by: Barber, Imelda S., et al.
Published: (2017)
by: Barber, Imelda S., et al.
Published: (2017)
Similar Items
-
In vivo pharmacological evaluation of a novel dual-target inhibitor and methylprednisolone as Alzheimer’s disease treatments
by: Zhang, Bocheng
Published: (2023) -
Alternative splicing and the inhibition of splicing kinases in Alzheimer’s Disease
by: Alalwany, Roaa
Published: (2021) -
Investigating genetic variation in Alzheimer’s disease
by: Patel, Tulsi
Published: (2018) -
Multitarget drug design strategy in Alzheimer’s disease: focus on cholinergic transmission and amyloid-β aggregation
by: Simioni, Elena, et al.
Published: (2017) -
Default mode network perturbations in Alzheimer's disease: an fMRI study in Klang Valley, Malaysia
by: Mohad Azmi, Nur Hafizah, et al.
Published: (2024)