A Scalable Synthesis of Chiral Himbert Diene Ligands for Asymmetric Catalysis
Here, is presented a intramolecular [4+2] cycloaddition of a simply attained chiral allenecarboxanilide readily affords pseudoenantiomeric bicyclo[2.2.2]octa-2,5-dienes containing an alkenyl bromide, which can be readily functionalized to give diverse chiral diene ligands. The synthesis is straightf...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2024
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| Online Access: | https://eprints.nottingham.ac.uk/77486/ |
| _version_ | 1848801004220317696 |
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| author | LI, Hongyi |
| author_facet | LI, Hongyi |
| author_sort | LI, Hongyi |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Here, is presented a intramolecular [4+2] cycloaddition of a simply attained chiral allenecarboxanilide readily affords pseudoenantiomeric bicyclo[2.2.2]octa-2,5-dienes containing an alkenyl bromide, which can be readily functionalized to give diverse chiral diene ligands. The synthesis is straightforward and easily conducted on multigram scales. These ligands exhibit high performance in nine types of enantioselective Rh(I)-catalyzed 1,4-addition or 1,2-addition reactions, with up to 99% yield and >99% ee. |
| first_indexed | 2025-11-14T21:00:33Z |
| format | Thesis (University of Nottingham only) |
| id | nottingham-77486 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:00:33Z |
| publishDate | 2024 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-774862025-02-28T12:27:42Z https://eprints.nottingham.ac.uk/77486/ A Scalable Synthesis of Chiral Himbert Diene Ligands for Asymmetric Catalysis LI, Hongyi Here, is presented a intramolecular [4+2] cycloaddition of a simply attained chiral allenecarboxanilide readily affords pseudoenantiomeric bicyclo[2.2.2]octa-2,5-dienes containing an alkenyl bromide, which can be readily functionalized to give diverse chiral diene ligands. The synthesis is straightforward and easily conducted on multigram scales. These ligands exhibit high performance in nine types of enantioselective Rh(I)-catalyzed 1,4-addition or 1,2-addition reactions, with up to 99% yield and >99% ee. 2024-07-24 Thesis (University of Nottingham only) NonPeerReviewed application/pdf en arr https://eprints.nottingham.ac.uk/77486/1/Synthesis%20of%20New%20Chiral%20Himbert%20Dienes%20as%20Ligand%20for%20Enantioselective%20Metal-Correction.pdf LI, Hongyi (2024) A Scalable Synthesis of Chiral Himbert Diene Ligands for Asymmetric Catalysis. PhD thesis, University of Nottingham. Asymmetric synthesis Chiral compounds metal catalysts |
| spellingShingle | Asymmetric synthesis Chiral compounds metal catalysts LI, Hongyi A Scalable Synthesis of Chiral Himbert Diene Ligands for Asymmetric Catalysis |
| title | A Scalable Synthesis of Chiral Himbert Diene Ligands for Asymmetric Catalysis |
| title_full | A Scalable Synthesis of Chiral Himbert Diene Ligands for Asymmetric Catalysis |
| title_fullStr | A Scalable Synthesis of Chiral Himbert Diene Ligands for Asymmetric Catalysis |
| title_full_unstemmed | A Scalable Synthesis of Chiral Himbert Diene Ligands for Asymmetric Catalysis |
| title_short | A Scalable Synthesis of Chiral Himbert Diene Ligands for Asymmetric Catalysis |
| title_sort | scalable synthesis of chiral himbert diene ligands for asymmetric catalysis |
| topic | Asymmetric synthesis Chiral compounds metal catalysts |
| url | https://eprints.nottingham.ac.uk/77486/ |