Evaluation of Replication Protein A (RPA) as a prognostic and therapeutic target in breast and ovarian cancer

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Evaluation of Replication Protein A (RPA) as a prognostic and therapeutic target in breast and ovarian cancer

Introduction: Replication protein A is a heterotrimeric complex composed of three linked subunits encoded by unique genes: RPA1 (chromosome 17p13, 70 kDa), RPA2 (chromosome 1p36.11, 32 kDa), and RPA3 (chromosome 7p13.3, 14 kDa). RPA is a critical ssDNA binding protein that coats and protects exposed...

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Bibliographic Details
Main Author:	Algethami, Mashael
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2024
Subjects:	Replication protein A; Oligosaccharide/oligonucleotide binding fold; DNA binding; Pathogenesis; Breast cancer; Ovarian cancer
Online Access:	https://eprints.nottingham.ac.uk/77407/

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