Biomedical application of OrbiSIMS in cancer: identification of anti-cancer agents and metabolite profiles
Small molecule targeted therapies, which have been widely adopted in cancer treatments, deliver drugs directly to specific targets. Therapeutic efficacy is achieved once the target attains the necessary drug concentration. In the pursuit of novel drug candidates, the use of advanced analytical techn...
| Main Author: | Lu, Yonghui |
|---|---|
| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2023
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/76555/ |
Similar Items
Synthesis of ganoderic acid analogues to investigate their activity as anti-prostate cancer agents
by: Al-Obaidi, Mohammed
Published: (2019)
by: Al-Obaidi, Mohammed
Published: (2019)
The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power
by: Passarelli, Melissa K., et al.
Published: (2017)
by: Passarelli, Melissa K., et al.
Published: (2017)
Uncovering the molecular compositions, origins and formation pathways of engine deposits using OrbiSIMS
by: Edney, Max
Published: (2022)
by: Edney, Max
Published: (2022)
Enabling in situ protein analysis for pharmaceutical applications using 3D OrbiSIMS
by: Kotowska, Anna
Published: (2022)
by: Kotowska, Anna
Published: (2022)
The development of novel theranostic agents for breast cancer imaging and treatment
by: Duthoit, Sophie
Published: (2021)
by: Duthoit, Sophie
Published: (2021)
Novel orlistat LDL-like nanoparticles as potential anti-cancer medicines
by: Bebawy, George
Published: (2022)
by: Bebawy, George
Published: (2022)
Development and Encapsulation of Affibody-Apoferritin Biologics for the Targeted Treatment of Breast Cancer
by: Holden, Isobel R
Published: (2025)
by: Holden, Isobel R
Published: (2025)
Passerini multicomponent reaction: a versatile synthesis of nanomedicines for triple negative breast cancer treatment
by: Travanut, Alessandra
Published: (2021)
by: Travanut, Alessandra
Published: (2021)
The use of agonistic anti-CD40 therapy in treatments for cancer
by: Khong, A., et al.
Published: (2012)
by: Khong, A., et al.
Published: (2012)
Docetaxel-loaded magnetic nanostructured lipid carrier functionalized with fish oil-coated iron oxide nanoparticles intended for lung cancer treatment
by: Idris, Auni Hamimi
Published: (2021)
by: Idris, Auni Hamimi
Published: (2021)
Probing the distribution of pharmaceutical compounds in cells using ToF-SIMS
by: Newman, Carla A.F. Fernandes
Published: (2019)
by: Newman, Carla A.F. Fernandes
Published: (2019)
Investigating ApoE4-Mediated Molecular Alterations in H4 Neuroglioma Cells of Alzheimer’s Disease Using OrbiSIMS and LC-MS/MS.
by: Lu, Li
Published: (2025)
by: Lu, Li
Published: (2025)
Development and structure activity relationship of diarylpentadienone and chalcone analogues as potential anti-inflammatory agent
by: Mohd Faudzi, Siti Munirah
Published: (2015)
by: Mohd Faudzi, Siti Munirah
Published: (2015)
Analysis of squalene and its transformation by-products in latent fingermarks by ultrahigh-performance liquid chromatography-high resolution accurate mass Orbitrap™ mass spectrometry
by: Dorakumbura, Buddhika, et al.
Published: (2019)
by: Dorakumbura, Buddhika, et al.
Published: (2019)
Surface Mass Spectrometry for in situ Metabolomic Analysis of Human Brain Tumours
by: He, Wenshi
Published: (2023)
by: He, Wenshi
Published: (2023)
Engineering a Mastoparan Peptide Concatemer Prodrug From CircRNA for Cancer Therapy
by: Grewcock, Declan
Published: (2023)
by: Grewcock, Declan
Published: (2023)
Antiproliferative effects of zerumbone-hydroxypropyl-ß-cyclodextrin inclusion complex on HepG2 liver cancer cells in vitro
by: Muhammad Nadzri, Nabilah
Published: (2013)
by: Muhammad Nadzri, Nabilah
Published: (2013)
Counting the costs of cancer care: breast, cervical and lung cancer in Trent
by: Wolstenholme, Jane
Published: (2001)
by: Wolstenholme, Jane
Published: (2001)
Characterization and anti-cancer effects of citral-loaded nanostructured lipid carrier in breast cancer cells in vitro and in vivo
by: Nordin, Noraini
Published: (2017)
by: Nordin, Noraini
Published: (2017)
Curcumin containing chitosan-pectinate nanoparticulate drug delivery system for colon cancer treatment
by: Alkhader, Enas Ali
Published: (2018)
by: Alkhader, Enas Ali
Published: (2018)
Evaluation of transcriptional cyclin dependent kinase inhibitors as potential cancer therapeutics
by: Liu, Xiangrui
Published: (2012)
by: Liu, Xiangrui
Published: (2012)
A Combined Recombinant Retroviral-Based Therapy for Colon Cancer in the Murine Model Using Anti-Tumorigenic and Anti-Angiogenic Agents
by: Nik Abd. Rahman, Nik Mohd. Afizan
Published: (2011)
by: Nik Abd. Rahman, Nik Mohd. Afizan
Published: (2011)
Antinociceptive and Anti-Inflammatory Activities of Zerumbone from Zingiber Zerumbet (l.) Roscoe ex sm., and its Possible Mechanisms of Action
by: Perimal, Enoch Kumar
Published: (2012)
by: Perimal, Enoch Kumar
Published: (2012)
Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases
by: Harguindey, Salvador, et al.
Published: (2017)
by: Harguindey, Salvador, et al.
Published: (2017)
Investigation of metabolic effects of polymer nanomedicines using advanced metabolomics methods
by: AbuHammad, Ala
Published: (2024)
by: AbuHammad, Ala
Published: (2024)
Hyaluronic acid/chitosan-coated poly (lactic-co-glycolic acid) nanoparticles to deliver paclitaxel and temozolomide for oral cancer cells
by: Hassn Ali, Mesrati Malak
Published: (2022)
by: Hassn Ali, Mesrati Malak
Published: (2022)
Evaluation of Newcastle disease virus as an oncolytic agent in colorectal cancer cell lines
by: Chia, Suet Lin
Published: (2012)
by: Chia, Suet Lin
Published: (2012)
Novel strategies for inhibiting cancer growth
by: Schaefer, Rainer
Published: (2008)
by: Schaefer, Rainer
Published: (2008)
In Vitro Mass Propagation, Anti-Cancer Activity and Phytochemical Analysis of Typhonium Flagelliforme
by: Galehpardsari, Motahareh Nobakht
Published: (2009)
by: Galehpardsari, Motahareh Nobakht
Published: (2009)
Synthesis and biological evaluation of new titanium (IV) complexes and their use in anti-cancer treatment
by: ABID, Mohammed Adnan
Published: (2021)
by: ABID, Mohammed Adnan
Published: (2021)
Effect of combination therapy of ruthenium polypyridyl complex, [Ru(dppz)2(PIP)]2+ and parp inhibitors against several cancer cell lines
by: Yusoh, Nur Aininie
Published: (2020)
by: Yusoh, Nur Aininie
Published: (2020)
Antioxidant, anti-inflammatory and anti-proliferative effects of methanolic leaf extract of Muntingia calabura L. on colon cancer
by: Md Nasir, Nur Liana
Published: (2017)
by: Md Nasir, Nur Liana
Published: (2017)
Toxicity and anti-breast cancer properties of thymoquinone-loaded nanostructured lipid carrier in mice
by: Ong, Yong Sze
Published: (2019)
by: Ong, Yong Sze
Published: (2019)
Potential inhibition of pro-inflammatory mediators by Ficus deltoidea jack leaves aqueous extract in lipopolysaccharide-induced microglial cells
by: Zolkiffly, Siti Zaidathul Iman
Published: (2021)
by: Zolkiffly, Siti Zaidathul Iman
Published: (2021)
Polyadenylation as a target for the treatment of breast cancer
by: Thiyab, Asraa
Published: (2025)
by: Thiyab, Asraa
Published: (2025)
Cytotoxic effects of 7-geranyloxycinnamic acid isolated from Melicope lunu-ankenda (Gaertn) T.G.Hartley leaves on breast cancer cell lines (MCF-7 and MDA-MB-231
by: Eliaser, Enas Mohamed Abdaallah
Published: (2022)
by: Eliaser, Enas Mohamed Abdaallah
Published: (2022)
Comparative metabolic changes of tissues and plasma in breast cancer patients / Erda Syerena Rosli
by: Rosli, Erda Syerena
Published: (2015)
by: Rosli, Erda Syerena
Published: (2015)
Formulation and optimization of nanoemulsion containing gemcitabine for lung cancer treatment
by: Wahgiman, Nadiatul Atiqah
Published: (2019)
by: Wahgiman, Nadiatul Atiqah
Published: (2019)
Apoptotic mechanism of apigenin and rutin in ER+- breast cancer cells, MCF-7 / Roziana Kamaludin
by: Kamaludin, Roziana
Published: (2015)
by: Kamaludin, Roziana
Published: (2015)
Interplay between hypoxia and gastrin in gastrointestinal cancer
by: Royal, E.L.
Published: (2009)
by: Royal, E.L.
Published: (2009)
Similar Items
-
Synthesis of ganoderic acid analogues to investigate their activity as anti-prostate cancer agents
by: Al-Obaidi, Mohammed
Published: (2019) -
The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power
by: Passarelli, Melissa K., et al.
Published: (2017) -
Uncovering the molecular compositions, origins and formation pathways of engine deposits using OrbiSIMS
by: Edney, Max
Published: (2022) -
Enabling in situ protein analysis for pharmaceutical applications using 3D OrbiSIMS
by: Kotowska, Anna
Published: (2022) -
The development of novel theranostic agents for breast cancer imaging and treatment
by: Duthoit, Sophie
Published: (2021)