Aberrant DNA methylation and its regulation of gene expression in airway smooth muscle cells of individuals with asthma

QR Code

Aberrant DNA methylation and its regulation of gene expression in airway smooth muscle cells of individuals with asthma

Asthma is a chronic airways disease affecting 262 million people worldwide, over 8 million people in the UK. Symptoms include wheezing, breathlessness, chest tightness and coughing, and are truly debilitating. Asthma exacerbations cause more severe versions of these symptom and 1200 people a year di...

Full description

Bibliographic Details
Main Author:	Clifford, Rachel Louise
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2023
Subjects:	airway smooth muscle DNA methylation gene expression asthma
Online Access:	https://eprints.nottingham.ac.uk/76545/

Similar Items

MMP-1 activation contributes to airway smooth muscle growth and asthma severity
by: Naveed, Shams-un-nisa, et al.
Published: (2017)

The role of histone arginine methylation in cytokine/chemokine gene expression in airway smooth muscle cells in asthma
by: Kaczmarek, Klaudia
Published: (2019)

Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD
by: Clifford, Rachel L., et al.
Published: (2018)

Matrix metalloproteinase-1 mediated extra-cellular matrix remodelling contributes to airway smooth muscle growth and asthma severity
by: Naveed, Shams-un-nisa
Published: (2018)

In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss
by: Chernyavsky, Igor L., et al.
Published: (2018)

Effect of cigarette smoke extract on inflammatory cytokine production and corticosteroid insensitivity in human airway smooth muscle cells
by: Alahmari, Mushabbab
Published: (2022)

Pharmacological ablation of the airway smooth muscle layer—Mathematical predictions of functional improvement in asthma
by: Donovan, G.M., et al.
Published: (2020)

Utility of the precision cut lung slice model to investigate airway smooth muscle contraction
by: Fox, Jane
Published: (2011)

An in vitro and in silico study of altered airway smooth muscle structure and function in a remodelled asthmatic airway
by: Brown, Sarah
Published: (2023)

Clonally expanded human airway smooth muscle cells exhibit morphological and functional heterogeneity
by: Singh, Shailendra R., et al.
Published: (2014)

Investigating a role for heterotrimeric G-proteins in activating TGFβ in asthma
by: Middlewick, Robert James
Published: (2020)

Genome-wide methylation analysis identifies genes silenced in non-seminoma cell lines
by: Noor, Dzul Azri Mohamed, et al.
Published: (2016)

Assessing the relationship between DNA methylation and gene expression in germ cell tumours
by: Alhazmi, Safiah
Published: (2016)

Cytotoxic Effect of Betulinic Acid on Vascular Smooth Muscle Cells
by: Vadivelu, Raja Kumar
Published: (2009)

Modelling cell–matrix interactions in airway smooth muscle cells
by: Irons, Linda
Published: (2019)

Mechanisms of transforming growth factor-β activation in airway smooth muscle cells and its role in asthma
by: Tatler, Amanda Louise
Published: (2010)

Quantitative genome-wide methylation analysis of high-grade non-muscle invasive bladder cancer
by: Kitchen, Mark O., et al.
Published: (2016)

Airway and parenchymal strains during bronchoconstriction in the precision cut lung slice
by: Hiorns, Jonathan E., et al.
Published: (2016)

Assessing the unified airway hypothesis in children via transcriptional profiling of the airway epithelium
by: Kicic, Anthony, et al.
Published: (2020)

The transcriptional regulation of VEGF production from pulmonary artery smooth muscle cells by TGFβ1
by: Clifford, Rachel
Published: (2009)

Evidence for a novel Kit adhesion domain mediating human mast cell adhesion to structural airway cells
by: Gough, Kevin C., et al.
Published: (2015)

Airway remodeling blockade with an orally active geranyl acetophenone
by: Lee, Yu Zhao
Published: (2017)

The Ability of Nutrition to Mitigate Epigenetic Drift: A Novel Look at Regulating Gene Expression.
by: D Palmer, Raymond, et al.
Published: (2021)

Nucleotide methylation and neurocognitive phenotypes
by: Flitton, Miles
Published: (2018)

The role of histone arginine methylation in gene expression of airway smooth muscle cells in asthma
by: Kaczmarek, K.A., et al.
Published: (2016)

A prebiotic galactooligosaccharide mixture reduces severity of hyperpnoea-induced bronchoconstriction and markers of airway inflammation
by: Williams, Neil C., et al.
Published: (2016)

The differential effects of azithromycin on the airway epithelium in vitro and in vivo
by: Slater, Mariel, et al.
Published: (2016)

Rare variants in nucleotide methylation genes and neurodevelopmental disorders
by: Parke, Adam
Published: (2019)

The role of histone arginine methylation in gene expression of airway smooth muscle cells in asthma
by: Kaczmarek, K.A., et al.
Published: (2017)

Burden of disease and benefits of exercise in fixed airway obstruction asthma
by: Turner, Sian Elizabeth
Published: (2009)

Mathematical Models of Pro-remodelling Growth Factor Activation in Asthmatic Airways
by: Pybus, Hannah J.
Published: (2020)

Assessing DNA methylation epialleles for human cognitive dysfunction and brain disease
by: Rielly, Nicholas Jude
Published: (2020)

Investigating the potential role of DNA (hydroxy)methylation in the control of post-stroke axon growth
by: Wallis, Marcus
Published: (2020)

Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation
by: Clifford, Rachel L., et al.
Published: (2017)

Integrated framework with association analysis for gene selection in microarray data classification
by: Ong, Huey Fang
Published: (2011)

Effects of 2,4,6-trihydroxy-3-geranyl acetophenone on growth factor-induced human bronchial smooth muscle cell proliferation in asthma
by: Yap, Hui Min
Published: (2018)

Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery
by: Varadhan, Krishna K., et al.
Published: (2017)

A constitutive model for cytoskeletal contractility of smooth muscle cells
by: Liu, Tao
Published: (2014)

Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation
by: Jevnikar, Zala, et al.
Published: (2018)

Genome-wide nucleosome map and cytosine methylation levels of an ancient human genome
by: Pedersen, J., et al.
Published: (2014)