Investigations into novel small molecules as potential treatments for idiopathic pulmonary fibrosis and malaria

QR Code

Investigations into novel small molecules as potential treatments for idiopathic pulmonary fibrosis and malaria

Small molecules provide relatively inexpensive therapeutics for a range of conditions. In contrast with antibody-conjugate treatments and more elaborate treatment options, use of small molecules makes treatment affordable and accessible for all, around the world. This thesis details research into th...

Full description

Bibliographic Details
Main Author:	Park, Jozef
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2022
Subjects:	Novel small molecules Idiopathic pulmonary fibrosis Malaria
Online Access:	https://eprints.nottingham.ac.uk/69247/

Similar Items

Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review
by: Hutchinson, John P., et al.
Published: (2015)

The role of Interleukin-33 in the development of idiopathic pulmonary fibrosis
by: Stephenson, Katherine
Published: (2021)

Evaluation of activity limitation in patients with idiopathic pulmonary fibrosis grouped according to Medical Research Council Dyspnea Grade
by: Kozu, R., et al.
Published: (2014)

Increasing global mortality from idiopathic pulmonary fibrosis in the twenty-first century
by: Hutchinson, John P., et al.
Published: (2014)

Preparation of potent and selective αvβ6 integrin inhibitors for the treatment of idiopathic pulmonary fibrosis and synthetic approaches towards the total synthesis of mescengricin
by: Robinson, Henry Duncan
Published: (2021)

International comparative epidemiology of idiopathic pulmonary fibrosis
by: Hutchinson, John
Published: (2017)

The role of galectin-3 in the development of idiopathic pulmonary fibrosis
by: Parmar, Nimesh
Published: (2019)

Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF)
by: Barratt, Shaney L., et al.
Published: (2018)

cAMP mediated regulation of fibroblast to myofibroblast differentiation in idiopathic pulmonary fibrosis
by: Wright, Rebecca
Published: (2016)

Spatiotemporal regulation of anti-remodelling signalling pathways in primary human lung fibroblasts
by: Roberts, Maxine
Published: (2020)

In vitro modelling of respiratory infections in idiopathic pulmonary fibrosis (IPF) using human induced pluripotent stem cell (hiPSCs)-derived alveolar epithelial type II cells
by: Serna Valverde, Ana Lilia
Published: (2023)

Refining in-vivo models of pulmonary fibrosis
by: Habgood, Anthony
Published: (2018)

Interplay between EZH2 and G9a regulates CXCL10 gene repression in idiopathic pulmonary fibrosis
by: Coward, William R., et al.
Published: (2017)

Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study
by: Jenkins, R. Gisli, et al.
Published: (2015)

Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997-2008
by: Hutchinson, John P., et al.
Published: (2016)

The potential therapeutic effect of manipulating the extracellular matrix in idiopathic pulmonary fibrosis
by: Philp, Christopher J.
Published: (2016)

The role of mesenchymal G proteins in pulmonary fibrosis and lung development
by: Goodwin, Amanda T.
Published: (2021)

Application of a human primary epithelial-fibroblast co-culture system to study fibrosis
by: Richardson, Jaineeta
Published: (2017)

Canine idiopathic chronic hepatitis
by: Bexfield, Nicholas
Published: (2017)

Development of biocatalytic approaches and screening methodology for the synthesis of nitrogen-containing small molecules
by: Cairns, Ryan
Published: (2022)

Comparison between survival and severe models of malaria infection for better understanding of the underlying disease pathogenesis
by: Chong, Wing Chui
Published: (2013)

The inhibition of human lung fibroblast proliferation and differentiation by Gs-coupled receptors is not predicted by the magnitude of cAMP response
by: Roberts, Maxine J., et al.
Published: (2018)

Climatological and socioeconomic factors that predispose to the risk of malaria in Sudan
by: Mohammed, Ibrahim Musa Hassan
Published: (2012)

Structure activity relationships of αv integrin antagonists for pulmonary fibrosis by variation in aryl substituents
by: Adams, James, et al.
Published: (2014)

Effects of interleukin-18 modulation on the pathogenesis of malaria infection
by: Jabbarzare, Marzieh
Published: (2013)

Quantification of the effects of operative management for idiopathic scoliosis: implications for pathogenesis, pathomechanisms and future management
by: Pratt, Roland K.
Published: (2002)

Determining malaria risk factors in Abuja, Nigeria using various statistical approaches
by: Segun, Oguntade Emmanuel
Published: (2018)

Modulation of receptor for advanced glycation end products signal transduction pathway as therapeutic option for malaria therapy
by: Chuah, Yaw Kuang
Published: (2015)

Suberoylanilide hydroxamic acid – a potential epigenetic therapeutic agent for lung fibrosis?
by: Wang, Z., et al.
Published: (2009)

Role, involvement and potential of interleukin-27 as an immunotherapeutic target in murine malaria
by: Fazalul Rahiman, Siti Sarah
Published: (2012)

Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis
by: Calver, J.F.
Published: (2023)

Development of novel fluorescent dye molecules based on BODIPY
by: Hassanain, Hawazen
Published: (2019)

Screening the medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18
by: Paiardini, Alessandro, et al.
Published: (2015)

Factors associated with health seeking behavior for malaria treatment among caregivers of under-five children with fever in Imo State, Nigeria
by: Sampson, Emilia Oluchi
Published: (2018)

Predictors of malaria among pregnant women attending ante-natal clinic in general hospital in Zamfara State, Nigeria
by: Hadiza, Kallamu
Published: (2015)

Examining the mechanism of action of small-molecule negative allosteric modulators of the human chemokine receptor CXCR2
by: Nesheva, Desislava
Published: (2022)

Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis
by: Hurley, M.N., et al.
Published: (2012)

Development of microweir structure by lithographic fabrication process for malaria cell separation
by: Sivaraj, Lalitha
Published: (2016)

The pharmacokinetics and toxicity of morning vs. evening tobramycin dosing for pulmonary exacerbations of cystic fibrosis: a randomised comparison
by: Prayle, A.P., et al.
Published: (2015)

Differences in Response to Pulmonary Rehabilitation in Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease
by: Kuzu, R., et al.
Published: (2011)