Measuring ligand concentration where it matters: Assessing the “micro pharmacokinetic/pharmacodynamics” of adenosine receptor ligands

QR Code

Measuring ligand concentration where it matters: Assessing the “micro pharmacokinetic/pharmacodynamics” of adenosine receptor ligands

The methods used to determine fundamental pharmacological parameters almost exclusively assume that the concentration of drug in the local environment of the target receptor is equal to the concentration of drug that has been added to the system. It has, however, recently been shown that, dependent...

Full description

Bibliographic Details
Main Author:	Lochray, Jack
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2022
Subjects:	Adenosine receptor ligands Pharmacokinetic Pharmacodynamics Ligand concentration
Online Access:	https://eprints.nottingham.ac.uk/69169/

Similar Items

A non-imaging high throughput approach to chemical library screening at the unmodified adenosine-A3 receptor in living cells
by: Arruda, Maria Augusta, et al.
Published: (2017)

Investigating cooperativity across adenosine A3 receptor homo- and hetero-oligomers
by: Groenewoud, N.J.A.
Published: (2019)

Optimisation of Peptide Linker-based Fluorescent Ligands for the Histamine H1 Receptor
by: Kok, Zhi Yuan
Published: (2020)

Investigating ligand-directed signalling at the cannabinoid receptor 2
by: Hourani, Wafa
Published: (2019)

Sterically demanding pincer ligands for transition metal chemistry
by: Albelwe, Bayan L.
Published: (2025)

Cell adhesion: stochastic receptor-ligand binding under force
by: Bagdasar, Ovidiu
Published: (2011)

Synthesis, characterization, and bioactivities of dithiocarbazate-Schiff base ligands and their metal complexes
by: Low, May Lee
Published: (2014)

Alkaline earth complexes of a sterically demanding guanidinate ligand
by: Moxey, Graeme J., et al.
Published: (2015)

Geometric adventures with self-assembled metal-ligand coordination structures
by: Fan, Yucong
Published: (2024)

Discovering the molecular basis for ligand pharmacological activity on β-adrenoceptors
by: Bunsuz, Asuman
Published: (2023)

Design, synthesis and pharmacological evaluation of novel fluorescent ligands for the mu-opioid receptor
by: Marshall, William
Published: (2021)

Synthesis and Complexation of a Bulky Silyl Phosphanide and Extended PNNNP Carbazole-based Ligand
by: Churchill, Olivia
Published: (2024)

Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist
by: Stoddart, Leigh A., et al.
Published: (2015)

Using super resolution microscopy to investigate the role of actin in adenosine receptor organisation
by: Garlick, Evelyn
Published: (2023)

Molecular simulation of protein-ligand complexes
by: Guest, Ellen
Published: (2022)

Synthesis, characterization and biological activities of tridentate ons Schiff bases and their mixed-ligand metal complexes containing imidazole or benzimidazole
by: Mazlan, Nurul Ain
Published: (2014)

Investigating the molecular basis of biased signalling at cannabinoid receptors
by: Dennis, Morgan Jane
Published: (2023)

Design, Synthesis, and Evaluation of New P2Y2 Receptor Antagonists and Fluorescent Ligands
by: Knight, Rebecca
Published: (2025)

Hollow-Core Magnetic Colloidal Nanocrystal Clusters with Ligand-Exchanged Surface Modification as Delivery Vehicles for Targeted and Stimuli-Responsive Drug Release
by: Li, D., et al.
Published: (2012)

Potency and species specificity of aryl hydrocarbon receptor ligands
by: Wall, Richard John
Published: (2012)

N/P-based Sterically Demanding Ligands: Synthesis, Reactivity and Catalysis
by: Nolla Saltiel, Roberto
Published: (2019)

Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization
by: Hill, Stephen J., et al.
Published: (2014)

Illuminating the life of the adenosine receptors: development and application of subtype-selective fluorescent probes for the study of the human A1 and A2A adenosine receptors in living cells
by: Comeo, Eleonora
Published: (2022)

Synthesis, characterization and bioactivity of mixed-ligandCu(II) complexes containing Schiff bases derived fromS-benzyldithiocarbazate and saccharinate ligand and the X-raycrystal structure of the copper-saccharinate complex containing S-benzyl-b-N-(Synthesis, characterization and bioactivity of mixed-ligandCu(II) complexes containing Schiff bases derived fromS-benzyldithiocarbazate and saccharinate ligand and the X-raycrystal structure of the copper-saccharinate complex containing S-benzyl-b-N-(acet).
by: Crouse, Karen Anne, et al.
Published: (2007)

X-ray photoelectron spectroscopy as a probe of rhodium-ligand interaction in ionic liquids
by: Men, Shuan, et al.
Published: (2016)

Modelling the influence of ligand binding towards the structure and dynamics of protein arginine deiminase IV
by: Ibrahim, Zalikha
Published: (2017)

Hetero-Ligand peptide functionalization of gold nanoparticles for selective detection of cobalt (II) ions
by: Jamadon, Nur Khaliesah
Published: (2022)

Small molecule-based fluorescent probes as tool compounds for chemokine receptors CXCR4 and ACKR3
by: Dekkers, Sebastian
Published: (2019)

Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism
by: Corriden, Ross, et al.
Published: (2014)

Synthesis, characterization, and reactivity of a uranium(VI) carbene imido oxo complex
by: Lu, Erli, et al.
Published: (2014)

The design, synthesis and characterisation of subtype selective dipeptide-linked fluorescent ligands for human β1 and β2–adrenoceptors
by: Santu, L.T.
Published: (2017)

Synthesis, Characterization and Elucidation of the Structure–Activity Relationship of Heteroatom Donor Ligands and Their Complexes Derived From Substituted Dithiocarbazate Derivatives
by: How, Fiona Ni Foong
Published: (2008)

Identification of a Cyanine-dye labeled peptidic ligand for Y₁R and Y₄R, based upon the Neuropeptide Y C-terminal analogue, BVD-15
by: Liu, Mengjie, et al.
Published: (2016)

Improving the cellular invasion into PHEMA sponges by incorporation of the RGD peptide ligand: The use of copolymerization as a means to functionalize PHEMA sponges
by: Paterson, S., et al.
Published: (2013)

The ketimide ligand is not just an inert spectator: heteroallene insertion reactivity of an actinide-ketimide linkage in a thorium carbene amide ketimide complex
by: Lu, Erli, et al.
Published: (2014)

Vascular permeability, angiogenesis and the role of delta-like ligand 4
by: Boardman, Rachel
Published: (2017)

Real-time ligand binding of fluorescent VEGF-A isoforms that discriminate between VEGFR2 and NRP1 in living cells
by: Peach, Chloe J., et al.
Published: (2018)

The interaction of glycosylated major outer membrane protein of Campylobacter jejuni with natural and synthetic ligands
by: Okoye, Jennifer Chigozie
Published: (2021)

Biased allosteric modulators of metabotropic glutamate receptor 5
by: Sengmany, Kathy
Published: (2018)

Real-time analysis of the binding of fluorescent VEGF₁₆₅a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes
by: Kilpatrick, Laura E., et al.
Published: (2017)